Umgubo weSinomenine Hydrochloride
I-Sinomenine Hydrochloride yikhemikhali ephuma kwisityalo i-Sinomenium acutum, efumaneka kakhulu eMpuma Asia. Yi-alkaloid ebisoloko isetyenziswa kumayeza aseTshayina ngenxa yeempawu zayo zokulwa nokuvuvukala kunye ne-analgesic. Uhlobo lwe-hydrochloride yityuwa ephucula ukunyibilika kunye nozinzo lwe-compound, okwenza ifaneleke ngakumbi ukusetyenziswa ngamayeza.
I-Sinomenine Hydrochloride ifundwe ngemiphumo yayo yonyango enokuba nayo ekunyangeni izifo ezifana ne-rheumatoid arthritis, ngenxa yokukwazi kwayo ukuguqula inkqubo yomzimba yokuzikhusela nokunciphisa ukudumba. Isebenza ngokuthintela ukuveliswa kwee-cytokines ezibangela ukudumba kunye nezinye izinto ezibandakanyekayo kwimpendulo yokudumba.
Ukongeza kwimiphumo yayo yokulwa nokuvuvukala kunye neyokuthomalalisa iintlungu, iSinomenine Hydrochloride ikwabonakalise amandla okukhusela imithambo-luvo, ukulwa ne-fibrosis, kunye nemisebenzi yokulwa ne-tumor kwizifundo ezahlukeneyo zangaphambi kweklinikhi.
Igama Elisemthethweni: (9a,13a,14a)-7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-morphinan-6-one, i-monohydrochloride
Inombolo ye-CAS: 6080-33-7
Amagama afanayo: iCucoline NSC 76021
Ifomula yeMolekyuli： C19H23NO4 • HCl
Ubunzima befomula: 365.9
Ubumsulwa: ≥98% I-crystalline solid
Ukunyibilika (Funda malunga nokwahluka kokunyibilika)
I-DMF: 30 mg/ml
I-DMSO: 30 mg/ml
I-Ethanol: 5 mg/ml
I-PBS (pH 7.2): 5 mg/ml
Imvelaphi:Isityalo/iSinomenium acutum
Ulwazi lokuthumela kunye nokugcina:
Indawo yokugcina -20°C
Ukuthunyelwa: Ubushushu begumbi
Uzinzo: ≥ iminyaka emi-4
| Into | Inkcazo | Isiphumo |
| Uvavanyo (HPLC) | 98.0% | 98.12% |
| Inkangeleko | Umgubo omhlophe | Ithobela imithetho |
| Ubungakanani beParticle | 98% ukuya kwi-80mesh | Ithobela imithetho |
| Ivumba elibi | Uphawu | Ithobela imithetho |
| Incasa | Uphawu | Ithobela imithetho |
| Iimpawu zomzimba | ||
| Ilahleko xa komiswa | ≤0.5% | 0.38% |
| Uthuthu | ≤0.5% | 0.46% |
| Iintsimbi ezinzima | ||
| Iintsimbi ezinzima (njenge-Pb) | Imigangatho ye-USP (<10ppm) | <10ppm |
| I-Arsenic (As) | ≤2ppm | 0.78ppm |
| Inkokeli (Pb) | ≤2ppm | 1.13ppm |
| I-Cadmium (i-Cd) | ≤lpm | 0.36ppm |
| IMercary (Hg) | ≤0.1ppm | 0.01ppm |
| Intsalela yezibulali-zinambuzane | Ayifumaneki | Ayifumaneki |
| Inani elipheleleyo leePlate | I-NMT 10000cfu/g | 680 cfu/g |
| Imvubelo iyonke kunye noMbungu | I-NMT 100cfu/g | 87 cfu/g |
| E.Coli | I-NMT 30cfu/g | 10 cfu/g |
| I-Salmonella | Okungalunganga | Okungalunganga |
| Isiphelo | Ihambelana neMigangatho yeShishini | |
Iziphumo eziphambili zeSinomenine Hydrochloride ziquka:
(1) Ilwa nokudumba: Inciphisa ukudumba.
(2) I-Analgesic: Inceda ekunciphiseni iintlungu.
(3) Ithintela amasosha omzimba: Ithintela ukusebenza kwenkqubo yomzimba yokuzikhusela.
(4) I-Anti-rheumatic: Inyanga isifo samathambo esibizwa ngokuba yi-rheumatoid arthritis.
(5) Ukukhusela iiseli zemithambo-luvo: Ikhusela iiseli zemithambo-luvo ekonakalisweni.
(6) I-Anti-fibrotic: Ithintela okanye inciphisa i-fibrosis yezicubu.
I-Sinomenine Hydrochloride isetyenziswa kakhulu kwezi ndawo zilandelayo:
(1) I-Rheumatology: Unyango lwe-rheumatoid arthritis.
(2) Ulawulo lweentlungu: Ukunciphisa iintlungu ezingapheliyo.
(3) Ukulwa nokudumba: Ukunciphisa ukudumba.
(4) Ukuguqulwa kwamasosha omzimba: Ukuguqulwa kwenkqubo yomzimba yokuzikhusela.
(5) Ukhuseleko lwe-Neuro: Ukusetyenziswa okunokwenzeka kunyango lokukhusela i-neuro.
Inkqubo yokuvelisa iSinomenine Hydrochloride Powder ingashwankathelwa ngolu hlobo lulandelayo:
Ukulungiswa kwemifuno:Ukucoca nokomisa izinto eziluhlaza zesityalo.
Ukukhupha:Ukusebenzisa izinyibilikisi ezifana ne-ethanol ukutsala i-sinomenine kwizinto zesityalo.
Ukugxila:Ukuyikhupha i-solvent ukuze kugxilwe kwi-sinomenine.
Ukwenziwa kwe-alkalization:Ukulungisa i-pH ukuze iguqule i-sinomenine ibe yimo yayo yetyuwa.
Ukukhupha ulwelo-ulwelo:Ukucoca ngezinyibilikisi zendalo ezifana ne-anisole okanye i-1-heptanol.
Ukuhlamba:Ukuhlamba ngamanzi ukuze kususwe ukungcola kunye nemingxunya yesinyibilikisi.
Ukwanda kwe-asidi:Ukunciphisa i-pH ukuze kukhawuleziswe i-sinomenine hydrochloride.
Ukwenziwa kwekristale:Ukwenza iikristale ze-sinomenine hydrochloride.
Ukwahlukana:Ukucoca okanye ukucoca ukuze kwahlulwe iikristale kwisisombululo.
Ukomisa:Ukususa umswakama oseleyo kwiikristale.
Ukusila:Ukucola iikristale ezomileyo zibe ngumgubo ocolekileyo.
Ukuhluma:Ukuqinisekisa ukusasazwa kobukhulu beesuntswana ngokulinganayo.
Ulawulo lwemeko:Uvavanyo lokujonga ubumsulwa, ukugxila, kunye nemigangatho yezinto eziphilayo.
Ukupakisha:Ukupakisha okucocekileyo nokukhuselekileyo ukuze kusasazwe.
Indawo yokugcina: Gcina kwindawo epholileyo, eyomileyo, necocekileyo, Khusela ukufuma kunye nokukhanya okuthe ngqo.
Iphakheji enkulu: 25kg/idrama.
Ixesha lokuKhokhela: Iintsuku ezisi-7 emva kweodolo yakho.
Ubomi beShelufu: Iminyaka emi-2.
Phawula: Iinkcukacha ezenziwe ngokwezifiso nazo zinokufezekiswa.
Express
Ngaphantsi kwe-100kg, iintsuku ezi-3-5
Inkonzo yokungena emnyango kulula ukuyithatha impahla
Ngaselwandle
Ngaphezulu kwe-300kg, malunga neentsuku ezingama-30
Kufuneka umthengisi weenkonzo zokucoca iinqanawa ukusuka kwelinye izibuko ukuya kwelinye
Ngomoya
100kg-1000kg, iintsuku ezi-5-7
Kufuneka umthengisi weenkonzo zokucoca izikhululo zeenqwelo-moya ukusuka kwisikhululo seenqwelo-moya ukuya kwisikhululo seenqwelo-moya
I-Bioway Organic ifumene izatifikethi ze-USDA kunye ne-EU organic, i-BRC, i-ISO, i-HALAL, i-KOSHER, kunye ne-HACCP.
