I-Lycorine Hydrochloride
I-Lycorine hydrochloride yi-powder derivative emhlophe ukuya kwemhlophe ye-alkaloid lycorine, efumaneka kwizityalo zeLycoris radiata (L'Her.), kwaye ikwintsapho ye-Amaryllidaceae. I-Lycorine hydrochloride ineziphumo ezahlukeneyo ze-pharmacological, kubandakanya ukulwa ne-tumor, ukulwa nomhlaza, ukulwa ne-HCV, ukulwa nokuvuvukala, ukulwa neentsholongwane, ukulwa ne-angiogenesis, kunye neempawu zokulwa ne-malaria. Iyanyibilika emanzini, kwi-DMSO, nakwi-ethanol. Ulwakhiwo lwayo lweekhemikhali luphawulwa yisakhelo esintsonkothileyo se-steroidal esinencasa ekrakra enamaqela amaninzi asebenzayo, kubandakanya amaqela e-hydroxyl kunye nama-amino, anegalelo kwimisebenzi yayo yebhayoloji.
| Igama lemveliso | I-Lycorine hydrochloride CAS:2188-68-3 | ||
| Umthombo wezityalo | ILycoris | ||
| Imeko yokugcina | Gcina ngetywina kubushushu begumbi | Umhla wengxelo | 2024.08.24 |
| Into | Umgangatho | Isiphumo |
| Ubunyulu(IsiNgesi)I-HPLC） | I-Lycorine hydrochloride≥98% | 99.7% |
| Inkangeleko | Umgubo omhlophe ongacacanga | Ukuhambelana |
| Umlinganiswa womzimbai-ics | ||
| Ubungakanani bamasuntswana | I-NLT100% 80I-Mesh | Ukuhambelana |
| Ilahleko yokomisa | ≤1.0% | 1.8% |
| Inzima isinyithi | ||
| Iintsimbi zizonke | ≤10.0ppm | Ukuhambelana |
| Inkokeli | ≤2.0ppm | Ukuhambelana |
| I-Mercury | ≤1.0ppm | Ukuhambelana |
| I-Cadmium | ≤0.5ppm | Ukuhambelana |
| Iintsholongwane | ||
| Inani lilonke leebhaktheriya | ≤1000cfu/g | Ukuhambelana |
| Imvubelo | ≤100cfu/g | Ukuhambelana |
| I-Escherichia coli | Ayifakwanga | Ayifunyaniswanga |
| I-Salmonella | Ayifakwanga | Ayifunyaniswanga |
| I-Staphylococcus | Ayifakwanga | Ayifunyaniswanga |
| Izigqibo | Abafanelekileyo | |
Iimbonakalo:
(1) Ubunyulu obuphezulu:Imveliso yethu icutshungulwa ngocoselelo ukuqinisekisa umgangatho ophezulu wobunyulu, nto leyo ibalulekileyo ekusebenzeni kwayo nasekukhuselekeni kwayo kwiindlela ezahlukeneyo zokusebenza.
(2) Iimpawu Zokulwa Nomhlaza:Ibonakalise imiphumo ebalulekileyo yokulwa nomhlaza kwiintlobo ezahlukeneyo zomhlaza, zombini kwi-vitro nakwi-vivo, ngeendlela ezifana nokukhuthaza ukubanjwa komjikelo weseli, ukuqala i-apoptosis, kunye nokuthintela i-angiogenesis.
(3) Isenzo Esijolise Kwiinjongo Ezininzi:Kukholelwa ukuba iLycorine hydrochloride isebenzisana neethagethi ezininzi zeemolekyuli, inika ukusebenza kakuhle kwiiseli zomhlaza.
(4) Ubuthi obuphantsi:Ibonisa ubuthi obuphantsi kwiiseli eziqhelekileyo, nto leyo ebalulekileyo ekusetyenzisweni kwayo njengeyeza lonyango.
(5) Iprofayili ye-Pharmacokinetic:Le mveliso ifundwe ngenxa ye-pharmacokinetics yayo, ibonisa ukufunxwa ngokukhawuleza kunye nokususwa ngokukhawuleza kwi-plasma, nto leyo ibalulekileyo ekucwangcisweni kwedosi kunye nokulungiselela unyango.
(6) Iziphumo ezihambelanayo:I-Lycorine hydrochloride ibonakalise iziphumo eziphuculweyo xa isetyenziswa kunye nezinye iziyobisi, ezinokuba luncedo ekulweni nokunganyangeki kwamayeza kunye nokuphucula iziphumo zonyango.
(7) Ixhaswe luPhando:Le mveliso ixhaswa luphando olunzulu, olubonelela ngesiseko esiqinileyo sokusetyenziswa kwayo kuphuhliso lwamayeza kunye nokusetyenziswa kwezonyango.
(8) Uqinisekiso loMgangatho:Amanyathelo okulawula umgangatho angqongqo ayasebenza kuyo yonke inkqubo yemveliso ukuqinisekisa ukuhambelana nokuthembeka kwemveliso.
(9) Izicelo Ezininzi:Ifanelekile ukusetyenziswa kuphando nophuhliso lwezicelo zamayeza, kubandakanya ukufunyanwa kwamayeza kunye nophuhliso lonyango lomhlaza.
(10) Ukuthobela imithetho:Yenziwe ngokwemigangatho ye-GMP ukuqinisekisa ukhuseleko nokusebenza kakuhle kwemveliso.
(1) Ishishini leMithi:I-Lycorine hydrochloride isetyenziswa ekuphuhlisweni kwamayeza okulwa neentsholongwane kunye namayeza okulwa nomhlaza.
(2) Ishishini le-Biotechnology:Isetyenziswa kuphando nophuhliso lweearhente zonyango ezintsha kunye neendlela zokwenza amayeza.
(3) Uphando lwemveliso yendalo:I-Lycorine hydrochloride ifundwa ngenxa yeenzuzo zayo zempilo kunye neempawu zayo zonyango.
(4) Ishishini leekhemikhali:Ingasetyenziswa njengesixhobo esiphakathi seekhemikhali ekuhlanganiseni ezinye iikhompawundi.
(5) Ishishini lezolimo:I-Lycorine hydrochloride iye yaphandwa malunga nokuba inamandla kangakanani na njengesibulali-zinambuzane sendalo kunye nokulawula ukukhula kwezityalo.
Inkqubo yokukhupha i-lycorine hydrochloride idla ngokubandakanya la manyathelo abalulekileyo alandelayo ukuqinisekisa ubunyulu be-solvent kunye nokuphucula izinga lokubuyisela kwimeko yesiqhelo:
(1) Ukukhethwa kwezinto eziluhlaza kunye nonyango lwangaphambi kokuba zisetyenziswe:Khetha izinto ezifanelekileyo zesityalo se-Amaryllidaceae, ezifana neebhalbhu ze-Amaryllis, uze uzihlambe, uzomise uze uzityumze ukuqinisekisa ubunyulu bezinto eziluhlaza uze ubeke isiseko sokukhutshelwa kwazo okulandelayo.
(2)Unyango lwangaphambi kwe-enzyme edibeneyo:Sebenzisa ii-enzymes ezintsonkothileyo (ezifana ne-cellulase kunye ne-pectinase) ukuze unyange izinto ezicoliweyo kwangaphambili ukuze ubolise iindonga zeeseli zezityalo kwaye uphucule ukusebenza kakuhle kokukhupha.
(3)Nciphisa i-hydrochloric acid leaching:Xuba izinto ezisetyenzisiweyo ezilungisiweyo kunye nesisombululo se-hydrochloric acid esinyibilikisiweyo ukuze kukhutshwe i-lycorine. Ukusetyenziswa kwe-hydrochloric acid kunceda ukwandisa ukunyibilika kwe-lycorine, ngaloo ndlela kuphucula ukusebenza kakuhle kokukhupha.
(4)Ukukhupha okuncediswa yi-ultrasonic:Ukusetyenziswa kwetekhnoloji yokukhupha encediswa yi-ultrasonic kunokukhawulezisa inkqubo yokunyibilikisa i-lycorine kwi-solvent kwaye kuphucule ukusebenza kakuhle kokukhupha kunye nobunyulu.
(5)Ukukhupha i-chloroform:Ukukhupha kwenziwa ngezinyibilikisi ze-organic ezifana ne-chloroform, kwaye i-lycorine idluliselwa kwisigaba samanzi ukuya kwisigaba se-organic ukuze icoce ngakumbi i-compound ekujoliswe kuyo.
(6)Ukubuyiselwa kwesinyibilikisi:Emva kwenkqubo yokukhupha, isinyibilikisi siyafunyanwa ngokuphuma komphunga okanye ngokuhluzwa ukuze kuncitshiswe ukusetyenziswa kwesinyibilikisi kwaye kuphuculwe ukonga.
(7)Ukucoca nokomisa:Ngokusebenzisa amanyathelo afanelekileyo okucoca nokomisa, kufunyanwa umgubo we-lycorine hydrochloride ococekileyo.
Kuyo yonke inkqubo yokukhupha, ukulawula ukukhethwa kwesinyibilikisi, iimeko zokukhupha (ezifana nexabiso le-pH, ubushushu, kunye nexesha), kunye namanyathelo okucoca alandelayo ngundoqo wokuqinisekisa ubunyulu besinyibilikisi kunye nokuphucula izinga lokubuyisela kwimeko yesiqhelo. Ukusetyenziswa kwezixhobo zanamhlanje zokukhupha nokucoca, ezifana nee-ultrasonic extractors kunye neenkqubo ze-high-performance liquid chromatography (HPLC), kukwanceda ukuphucula ukusebenza kakuhle kokukhupha kunye nomgangatho wemveliso.
Indawo yokugcina: Gcina kwindawo epholileyo, eyomileyo, necocekileyo, Khusela ukufuma kunye nokukhanya okuthe ngqo.
Iphakheji enkulu: 25kg/idrama.
Ixesha lokuKhokhela: Iintsuku ezisi-7 emva kweodolo yakho.
Ubomi beShelufu: Iminyaka emi-2.
Phawula: Iinkcukacha ezenziwe ngokwezifiso nazo zinokufezekiswa.
Express
Ngaphantsi kwe-100kg, iintsuku ezi-3-5
Inkonzo yokungena emnyango kulula ukuyithatha impahla
Ngaselwandle
Ngaphezulu kwe-300kg, malunga neentsuku ezingama-30
Kufuneka umthengisi weenkonzo zokucoca iinqanawa ukusuka kwelinye izibuko ukuya kwelinye
Ngomoya
100kg-1000kg, iintsuku ezi-5-7
Kufuneka umthengisi weenkonzo zokucoca izikhululo zeenqwelo-moya ukusuka kwisikhululo seenqwelo-moya ukuya kwisikhululo seenqwelo-moya
I-Bioway Organic ifumene izatifikethi ze-USDA kunye ne-EU organic, i-BRC, i-ISO, i-HALAL, i-KOSHER, kunye ne-HACCP.
I-Lycorine yi-alkaloid yendalo efumaneka kwizityalo ezahlukeneyo, ingakumbi kusapho lwe-Amaryllidaceae. Nazi ezinye zezityalo ezaziwa ngokuba ne-lycorine:
I-Lycoris radiata(ekwaziwa ngokuba yiRed spider lily okanye iManjushage) sisichumiso semveli saseTshayina esiqulethe iLycorine.
I-Leucojum aestivum(ikhephu lasehlotyeni), likwaziwa ngokuba ne-lycorine.
Ungernia sewertzowiisesinye isityalo esivela kusapho lwe-Amaryllidaceae esixelwe ukuba siqulethe i-lycorine.
I-Hippeastrum hybrid (i-Easter lily)kunye nezinye izityalo ze-Amaryllidaceae ezinxulumene nazo ziyaziwa njengemithombo ye-lycorine.
Ezi zityalo zisasazeke kakhulu kwiindawo ezishushu nezishushu kwihlabathi liphela kwaye zinembali ende yokusetyenziswa kumayeza emveli. Ubukho be-lycorine kwezi zityalo bube ngumxholo wophando ngenxa yeempawu zayo ezinokubakho ze-pharmacological, kuquka nemiphumo yayo ebalulekileyo yokulwa nomhlaza njengoko kubonisiwe kwizifundo ezahlukeneyo.
I-Lycorine yi-alkaloid yendalo eneziphumo ezahlukeneyo zezonyango, kuquka nokusetyenziswa kwayo kunyango lomhlaza. Nangona ibonise iziphumo ezithembisayo kwizifundo ezahlukeneyo, kukho ezinye iziphumo ebezingalindelekanga ezixeliweyo kunye nezinto eziqwalaselwayo ezinxulumene nokusetyenziswa kwayo:
Ubuthi obuphantsi: I-Lycorine kunye netyuwa yayo ye-hydrochloride ngokubanzi ibonisa ubuthi obuphantsi, nto leyo ebonakala iluncedo kwiindlela zonyango. Kuye kwabonakala ukuba inemiphumo emibi embalwa kwiiseli zabantu eziqhelekileyo kunye neempuku ezisempilweni, nto leyo ebonisa ukuba kukho inqanaba elithile lokukhetha kwiiseli zomhlaza kunezicubu eziqhelekileyo.
Iziphumo zokungakhululeki okukhawulezileyo: Ukucaphuka nokuhlanza okukhawulezileyo kuye kwabonwa emva kokufakwa kwe-lycorine hydrochloride ngaphantsi okanye ngemithambo, ngokuqhelekileyo kuye kwehla kwiiyure eziyi-2.5 ngaphandle kokuchaphazela ukhuseleko lwe-biochemical okanye lwe-hematological.
Akukho Ulungelelwaniso LweeMoto Ezingasebenziyo: Izifundo zibonise ukuba iidosi ezilandelelanayo ze-lycorine azichaphazeli ulungelelwaniso lweeMoto kwiimpuku, njengoko zivavanyiwe luvavanyo lwe-rotarod, nto leyo ebonisa ukuba azikhokeleli kwimiphumo emibi yenkqubo ye-nervous system (CNS) enxulumene nolawulo lweeMoto.
Impembelelo kumsebenzi we-Spontaneous Locomotor: Kwidosi ye-30 mg/kg, i-lycorine ibonwe ukuba iphazamisa umsebenzi we-spontaneous locomotor kwiimpuku, njengoko kuboniswe kukwehla kokuziphatha kokukhulisa kunye nokwanda kokungakwazi ukuhamba.
Ukuziphatha Okuqhelekileyo kunye nempilo-ntle: Idosi ye-10 mg/kg ye-lycorine ayizange iphazamise ukuziphatha okuqhelekileyo kunye nempilo-ntle yeempuku, nto leyo ebonisa ukuba le inokuba yidosi efanelekileyo yovavanyo lwexesha elizayo lokusebenza kakuhle kwezonyango.
Akukho ziphumo zimbi zibalulekileyo kubunzima bomzimba okanye imeko yempilo: Ukunikwa kwe-lycorine kunye ne-lycorine hydrochloride akuzange kubangele iziphumo ebezingalindelekanga kubunzima bomzimba okanye imeko yempilo iyonke kwiimodeli zeempuku ezineethumba.
Kubalulekile ukuqaphela ukuba nangona i-lycorine ibonakalise amandla kuphando lwangaphambi konyango, uvavanyo lwetyhefu lwexesha elide lusanqongophala. Kufuneka uphando olongezelelekileyo ukuze kuqondwe ngokupheleleyo iprofayili yayo yokhuseleko, ngakumbi ekusetyenzisweni kwexesha elide nakwiimeko zonyango. Iziphumo ebezingalindelekanga kunye nokhuseleko lwe-lycorine zinokwahluka ngokuxhomekeke kumthamo, indlela yokusetyenziswa, kunye neempawu zesigulana ngasinye. Soloko unxibelelana neengcali zezempilo ngaphambi kokuba ucinge ngokusebenzisa nasiphi na isongezelelo okanye unyango olutsha.
