I-Sinomenine Hydrochloride Powder
ISinomenine Hydrochloride yikhemikhali ephuma kwisityalo iSinomenium acutum, esixhaphake ukufumaneka eMpuma Asia. Yi-alkaloid eye yasetyenziswa ngokwesiko kumayeza aseTshayina ngenxa yeempawu zayo zokuchasa ukudumba kunye ne-analgesic. Ifom ye-hydrochloride yityuwa eyandisa ukunyibilika kunye nokuzinza kwe-compound, okwenza ukuba ifaneleke ngakumbi ukusetyenziswa kwamayeza.
I-Sinomenine Hydrochloride ifundwe ngeziphumo zayo zonyango ezinokubakho ekuphatheni iimeko ezifana ne-rheumatoid arthritis, ngenxa yokukwazi ukulungelelanisa amajoni omzimba kunye nokunciphisa ukuvuvukala. Isebenza ngokuthintela ukuveliswa kwe-cytokines e-pro-inflammatory kunye nabanye abalamli ababandakanyekayo kwimpendulo yokuvuvukala.
Ukongeza kwiimpembelelo zayo ezichasayo kunye ne-analgesic, i-Sinomenine Hydrochloride nayo ibonise amandla okukhusela i-neuroprotection, i-anti-fibrosis, kunye ne-anti-tumor kwizifundo ezahlukeneyo zangaphambili.
Igama elisesikweni: (9a,13a,14a)-7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-morphinan-6-enye, monohydrochloride
Inombolo yeCAS: 6080-33-7
Izithethantonye:Cucoline NSC 76021
Ifomula yemolekyuli: C19H23NO4 • HCl
Ubunzima befomula: 365.9
Ubunyulu:≥98% Ikristale eqinileyo
Ukunyibilika(Funda malunga noMahluko ekunyibilikeni)
I-DMF: 30 mg / ml
I-DMSO: 30 mg/ml
I-Ethanol: 5 mg / ml
I-PBS (pH 7.2): 5 mg / ml
Imvelaphi:Isityalo/iSinomenium acutum
Ukuthumela ngenqanawe kunye nolwazi loGcino:
Ugcino -20°C
Ukuthumela ngenqanawa: Ubushushu beGumbi
Uzinzo:≥ iminyaka emi-4
| Into | Inkcazo | Isiphumo |
| Uvavanyo(HPLC) | 98.0% | 98.12% |
| Imbonakalo | Umgubo omhlophe | Iyahambelana |
| Ubungakanani beNcam | 98% ukuya kwi-80mesh | Iyahambelana |
| Ivumba | Uphawu | Iyahambelana |
| Ngcamla | Uphawu | Iyahambelana |
| Iimpawu zoMzimba | ||
| Ilahleko ekomisweni | ≤0.5% | 0.38% |
| Uthuthu | ≤0.5% | 0.46% |
| Iintsimbi ezinzima | ||
| Iintsimbi ezinzima(njenge Pb) | Imigangatho ye-USP(<10ppm) | <10ppm |
| Arsenic(As) | ≤2ppm | 0.78ppm |
| Khokela (Pb) | ≤2ppm | 1.13ppm |
| I-Cadmium(Cd) | ≤lppm | 0.36ppm |
| Mercary(Hg) | ≤0.1ppm | 0.01ppm |
| Intsalela Yezitshabalalisi | Ayifunyanwanga | Ayifunyanwanga |
| Iyonke iPlateCount | NMT 10000cfu/g | 680 cfu/g |
| Igwele elipheleleyo kunye noMngundo | NMT 100cfu/g | 87 cfu/g |
| E.Coli | NMT 30cfu/g | 10 cfu/g |
| Salmonella | Ibi | Ibi |
| Ukuqukumbela | Ihambelana noMgangatho woShishino | |
Iziphumo eziphambili zeSinomenine Hydrochloride ziquka:
(1) Ukuchasana nokuvuvukala: Ukunciphisa ukuvuvukala.
(2) I-Analgesic: Ibonelela ngokukhululeka kweentlungu.
(3) I-Immunosuppressive: Icinezela umsebenzi we-immune system.
(4) I-Anti-rheumatic: Inyanga isifo samathambo.
(5) I-Neuroprotective: Ikhusela iiseli ze-nerve emonakalweni.
(6) I-Anti-fibrotic: Ikhusela okanye iyanciphisa i-tissue fibrosis.
ISinomenine Hydrochloride isetyenziswa ikakhulu kwezi ndawo zilandelayo:
(1) I-Rheumatology: Unyango lwe-rheumatoid arthritis.
(2) Ulawulo lweentlungu: Ukunciphisa intlungu engapheliyo.
(3) Ukuchasana nokuvuvukala: Ukunciphisa ukuvuvukala.
(4) I-Immunomodulation: Ukuguqulwa kwamajoni omzimba.
(5) I-Neuroprotection: Ukusetyenziswa okunokwenzeka kwi-neuroprotective therapy.
Inkqubo yemveliso yeSinomenine Hydrochloride Powder inokushwankathelwa ngolu hlobo lulandelayo:
Ukulungiselela Amagqabi:Ukucoca kunye nokomisa isityalo ekrwada.
Ukutsalwa:Ukusebenzisa izinyibilikisi ezifana ne-ethanol ukukhupha i-sinomenine kwizinto zesityalo.
Ugxininiso:Ukukhupha i-solvent ukuze kugxininise umxholo we-sinomenine.
Ukwenziwa kweAlkalization:Ukulungelelanisa i-pH ukuguqula i-sinomenine kwifom yetyuwa.
Ukutsalwa kolwelo:Ukuhlanjululwa nge-solvents eziphilayo ezifana ne-anisole okanye i-1-heptanol.
Ukuhlamba:Ukuhlamba ngamanzi ukususa ukungcola kunye neempawu ze-solvent.
Ukufakwa kweAcid:Ukunciphisa i-pH kwi-precipitate sinomenine hydrochloride.
Crystallization:Ukwenza iikristale ze-sinomenine hydrochloride.
Ukwahlula:I-Centrifuging okanye ukuhluza ukwahlula iikristale kwisisombululo.
Ukomisa:Ukususa ukufuma okushiyekileyo kwiikristale.
Ukugaya:Ukugaya iikristale ezomileyo zibe ngumgubo ocolekileyo.
Sieving:Ukuqinisekisa ukuhanjiswa kobungakanani bamasuntswana afanayo.
Ulawulo lwemeko:Uvavanyo lokucoceka, ukugxila, kunye nemigangatho ye-microbiological.
Ukupakishwa:Ukupakishwa okungenazintsholongwane kunye nokukhusela ukuhanjiswa.
Ugcino: Gcina kwindawo epholileyo, eyomileyo, necocekileyo, Khusela kubumanzi nasekukhanyeni okuthe ngqo.
Iphakheji eninzi: 25kg / idrum.
Ixesha lokukhokela: Iintsuku ezi-7 emva komyalelo wakho.
Ubomi beShelf: iminyaka emi-2.
Phawula: Iinkcukacha ezilungiselelweyo nazo zinokufezekiswa.
Express
Ngaphantsi kwe-100kg, iintsuku ezi-3-5
Umnyango ukuya emnyango inkonzo lula ukuthatha iimpahla
Ngaselwandle
Ngaphezulu kwe-300kg, malunga neentsuku ezingama-30
Izibuko ukuya kwinkonzo yezibuko i-broker yobuchwephesha efunekayo
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100kg-1000kg, 5-7Days
Isikhululo seenqwelomoya ukuya kwinkonzo yesikhululo seenqwelomoya siyafuneka
I-Bioway Organic ifumene i-USDA kunye ne-EU organic, i-BRC, i-ISO, i-HALAL, i-KOSHER, kunye nezatifikethi ze-HACCP.
