I-Corydalis Extract Tetrahydropalmatine (dl-THP)
I-Tetrahydropalmatine (THP), ekwaziwa ngokuba yi-dl-THP, iCorydalin hydrochloride, okanye iCorydalin Tube Extract, yikhompawundi ehlelwe njenge-isoquinoline alkaloid. Ikhutshwa kwityhubhu yesityalo saseTshayina iCorydalis yanhusuo. I-THP yinto etyheli etyheli engenambala okanye ekhanyayo enencasa ekrakra kancinci kunye nendawo yokunyibilika ye-147-149°C. Ayinyibiliki emanzini kodwa inyibilika kakhulu kwi-ether, i-chloroform, kunye ne-ethanol. Iityuwa zayo ze-hydrochloride kunye ne-sulfate ziyanyibilika emanzini.
I-THP ifundwe ngeziphumo zayo ezahlukeneyo ze-pharmacological, kubandakanya i-analgesic, i-anesthetic, i-neuroprotective, i-antiplatelet aggregation, i-antiulcer, i-antitumor, kunye ne-anti-addiction properties. Kukholelwa ukuba inika iziphumo zayo ze-analgesic ngokuguqula umsebenzi we-central dopamine receptor kwaye ibonakalise amandla okukhusela ii-neurons kwi-ischemic effect. Ukongeza, i-THP ibonakalise iziphumo ze-antiplatelet aggregation kwaye iphandwe ngamandla ayo okunyanga izilonda, ukuthintela ukukhula kweeseli ze-tumor, kunye nokunceda ekuxhomekekeni kwiziyobisi.
Ngokubanzi, iTetrahydropalmatine (dl-THP) yikhompawundi eneempawu ezahlukeneyo ze-pharmacological kwaye ibingumxholo wophando olunzulu malunga nokusetyenziswa kwayo okunokwenzeka kwezonyango. Ukuze ufumane ulwazi oluthe kratya nxibelelana nathi.grace@biowaycn.com.
Nazi iimpawu zemveliso yeTetrahydropalmatine (THP) kunye neenzuzo zayo zempilo:
1. Iimpawu ze-Analgesic:I-THP ibonisa iziphumo zokuthomalalisa iintlungu ngokuguqula umsebenzi we-central dopamine receptor, inika isiqabu kwiintlungu ngaphandle kwamandla abonakalayo okulutha.
2. Iziphumo zokukhusela i-neuroprotective:I-THP ibonakalise amandla okukhusela ii-neurons kwi-ischemic ekonzakaleni, ukunciphisa i-neuronal apoptosis, kunye nokunciphisa amanqanaba e-glutamate engqondweni, nto leyo enokuba negalelo kwiimpawu zayo zokukhusela ii-neuro.
3. Ukuhlanganiswa kwe-Antiplatelet:Kufunyenwe ukuba i-THP ithintela ukuhlanganiswa kweeplatelet, nto leyo enokunciphisa umngcipheko wokwakheka kwe-blood clot kunye neziganeko ezinxulumene nentliziyo.
4. Inkxaso yezeMpilo yeSisu:I-THP ibonakalise iziphumo zokulwa nezilonda kwaye inokunceda ekunciphiseni ukukhutshwa kwe-asidi esiswini, inika isiqabu kwizilonda zesisu kunye neemeko ezinxulumene noko.
5. Umsebenzi onokwenzeka wokulwa nethumba:I-THP ibonakalise iziphumo ze-cytotoxic kwiiseli ze-tumor, nto leyo ebonisa indima enokubakho ekuthinteleni ukukhula kwe-tumor.
6. Iimpawu zokulwa nomlutha:I-THP ifundwe ngenxa yamandla ayo okunciphisa iimpawu zokurhoxa ezinxulumene ne-opioid kunye nokulutha okuvuselelayo, inika ithemba kunyango lokulutha kunye nokuthintela ukuphinda uqalise ukusebenzisa iziyobisi.
Ezi mpawu zibonisa iingenelo ezahlukeneyo zempilo kunye nokusetyenziswa okunokwenzeka kweTetrahydropalmatine (THP) kunyango.
I-Tetrahydropydalin (dl-THP) yeye-isoquinoline alkaloids kwaye yi-alkaloid, ikakhulu kwi-genus Corydalis lucidum (Yan Hu Suo), kodwa nakwezinye izityalo ezifana neStephania rotunda. Ezi zityalo zisetyenziswa ngokwesiko kumayeza esintu aseTshayina.ICorydalis sisityalo esihlala sikhula njengesityalo esinezityalo, esinobude obuyi-10 ukuya kwi-20 cm, sinee-tubers ezingqukuva. Iziqu zaso ezingaphezulu komhlaba zimfutshane kwaye zincinci, zine-scale ngaphezulu kwesiseko. Amagqabi asezantsi kunye namagqabi e-cauline afana ngesimo, aneziqu; amagqabi e-cauline ayatshintshana, anamagqabi ama-2 nama-3 adibeneyo. Igqabi lesibini lidla ngokuqhekeka lingaphelelanga kwaye linezikwere ezinzulu. Amagqabi amancinci aqinile, angqukuva, okanye angqukuva. Amgca, malunga ne-2 cm ubude, ane-apex ecacileyo okanye ebukhali kunye nemiphetho ecocekileyo. I-inflorescence yayo imile okwe-raceme, inamagqabi aphelayo okanye achaseneyo; ii-bracts zibanzi i-lanceolate; iintyatyambo zibomvu-mfusa kwaye zikhula ngokuthe tye kwi-pedicels ezibhityileyo, ezimalunga ne-6 mm ubude; i-calyx iwela kwangethuba; ii-petals ziyi-4 kwaye ii-whorls zangaphandle ziyi-2. Iziqwenga zikhulu kancinci, zinemiphetho epinki kunye nembindi oluhlaza-mfusa. Kukho icandelo elinye eliphezulu, kwaye umsila udlulela kwi-spur ende. Ubude be-spur bumalunga nesiqingatha sobude bubonke. Iinxalenye ezimbini zangaphakathi zincinci kuneenxalenye ezimbini zangaphandle. Isiphelo esiphezulu siluhlaza okwesibhakabhaka kwaye siphilile, kwaye icandelo elisezantsi lipinki; I-stamens ziyi-6, kwaye iintambo zidibene zibe ziibhanti ezimbini, nganye inee-anthers ezi-3; i-ovary i-flat-cylindrical, isitayela sifutshane kwaye sincinci, kwaye i-stigma yi-2, njengebhabhathane elincinci. Isiqhamo sayo yi-capsule. I-Corydalis iveliswa kakhulu ezintabeni okanye kwiindawo ezinengca. Iindawo eziphambili ezivelisayo ziquka iZhejiang, iHebei, iShandong, iJiangsu, nezinye iindawo.
| Uhlalutyo | Inkcazo |
| Uvavanyo | I-Tetrahydropalmatine ≥98% |
| Inkangeleko | Umgubo otyheli okhanyayo ukuya kumhlophe |
| Uthuthu | ≤0.5% |
| Ukufuma | ≤5.0% |
| Izibulali-zinambuzane | Okungalunganga |
| Iintsimbi ezinzima | ≤10ppm |
| Pb | ≤2.0ppm |
| As | ≤2.0ppm |
| Ivumba elibi | Uphawu |
| Ubungakanani besuntswana | I-100% ukuya kwi-80 mesh |
| Izinto ezibangela iintsholongwane: | |
| Iibhaktheriya zizonke | ≤1000cfu/g |
| Iifungi | ≤100cfu/g |
| ISalmgosella | Okungalunganga |
| I-Coli | Okungalunganga |
Nazi iindlela zokusetyenziswa kwemveliso zeTetrahydropalmatine (THP):
1. Amayeza:I-THP isetyenziswa kwishishini lamayeza ekuphuhliseni amayeza okulawula iintlungu kunye namayeza okukhusela imithambo-luvo.
2. Izakhamzimba:I-THP isetyenziswa kwishishini le-nutraceutical ekwenzeni izongezo ezijolise ekunciphiseni iintlungu kunye nenkxaso yempilo yesisu.
3. I-Biotechnology:I-THP ifumana usetyenziso kwi-biotechnology kuphando malunga nonyango lwe-antiplatelet kunye nezinye izincedisi zonyango lomhlaza.
4. Ukhathalelo lwempilo:I-THP ifakwe kwiimveliso zonyango ukulawula umlutha kunye neempawu zokurhoxa ezinxulumene nokusetyenziswa kwe-opioid kunye nokusetyenziswa kwezinto ezivuselelayo.
5. Izinto zokuthambisa:I-THP iphononongwa kwiimveliso ze-cosmeceuticals ukuze kufunyanwe ukuba ingaba luncedo kangakanani na kwimpilo yolusu kunye nokusetyenziswa kwayo ekulweni nokudumba.
Ezi mveliso zibonisa ukusetyenziswa okuhlukeneyo kweTetrahydropalmatine (THP) kwiimeko ezahlukeneyo zophuhliso lwemveliso kunye nophando.
Iimveliso zethu zenziwa kusetyenziswa amanyathelo olawulo lomgangatho angqongqo kwaye zilandela imigangatho ephezulu yeenkqubo zemveliso. Sibeka phambili ukhuseleko kunye nomgangatho wemveliso yethu, siqinisekisa ukuba iyahlangabezana neemfuno zomthetho kunye neziqinisekiso zoshishino. Oku kuzibophelela kumgangatho kujolise ekusekeni ukuthembana kunye nokuzithemba ekuthembekeni kwemveliso yethu. Inkqubo yemveliso ngokubanzi yile ilandelayo:
Indawo yokugcina:Gcina kwindawo epholileyo, eyomileyo, necocekileyo, Khusela ukufuma kunye nokukhanya okuthe ngqo.
Iphakheji enkulu:20~25kg/idrama.
Ixesha lokukhokhela:Iintsuku ezisi-7 emva kweodolo yakho.
Beka ubomi kwishelufa:iminyaka eyi-2.
Ingxelo:Iinkcukacha ezenziwe ngokwezifiso zinokufezekiswa.
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