Umgubo weRotundine ococekileyo (l-tetrahydropalmatine,l-THP)
I-Rotundine, ekwaziwa ngokuba yi-l-tetrahydropalmatine (l-THP), yikhompawundi eneempawu ze-pharmacological ezichaphazela inkqubo ye-nervous central kunye ne-cardiovascular system. Kuye kwaxelwa ukuba ineziphumo zokuthomalalisa iintlungu, ukuthomalalisa, ukutyhafisa, kunye nokuxhalaba. Ukongeza, ibonakalisiwe ukuba ineziphumo zokukhusela kwi-cerebral and myocardial ischemia-reperfusion injury. I-Rotundine ikwaziwa nangokukwazi kwayo ukubuyisela umva ukuxhathisa amayeza amaninzi kwiiseli zomhlaza kunye neempawu zayo zokuthintela i-calcium channel.
Ingafunyanwa kwiityhubhu zeStephania tetrandra kunye neCorydalis yanhusuo, okanye ngeendlela zokwenziwa kweekhemikhali. Yenziwe kwi-tetrahydropalmatine ngokunciphisa, ukuqhekeka, kunye neempendulo ze-alkalization. I-tetrahydropalmatine ene-iodine inokuveliswa kwi-tetrahydropalmatine ngokwenziwa kwe-alkalization kunye ne-oxidation ukuze kwenziwe kwakhona.
Kwi-pharmacokinetics, iRotundine ifunxwa kakuhle emva kokusetyenziswa ngomlomo kwaye isasazwa kakhulu kwizicubu zamafutha, ilandelwe yimiphunga, isibindi, kunye nezintso. Ikhutshwa kakhulu ngezintso. Izifundo kwiimpuku kunye noonogwaja zibonise ukuba iRotundine inokungena kumqobo wegazi-ubuchopho ize ingene kwizicubu zobuchopho, kunye noxinzelelo lobuchopho oluphantsi kunoxinzelelo lwegazi emva kweeyure ezi-2.
Ngenxa yeziphumo ezibi, iRotundine inokubangela ukozela, isiyezi, ukudinwa, isicaphucaphu, kunye nokothuka ngamanye amaxesha ngenxa ye-allergy. Amanyathelo okhuseleko aquka ukuphepha ukusebenzisa kubafazi abakhulelweyo nabancancisayo, ukuqaphela ukuba kunokwenzeka ukuba banyamezele ukusetyenziswa ixesha elide, kunye nokusebenzisa isilumkiso xa usebenzisa kunye ne-central nervous system depressants, kunye nohlengahlengiso olufanelekileyo lwedosi ukuba kuyimfuneko.
Ngamafutshane, iRotundine yikhemikhali enemiphumo eyahlukeneyo yezonyango, kwaye iipropati zayo ziyenza ibe yinto enomdla kuphando olwahlukeneyo, kubandakanya ulawulo lweentlungu, impilo yentliziyo, kunye nonyango lomhlaza. Ukuze ufumane ulwazi oluthe kratya nxibelelana nathi.grace@biowaycn.com.
Ukuphelisa iintlungu:I-Rotundine ibonakalisiwe ukuba ineempawu zokuthomalalisa iintlungu, nto leyo eyenza ukuba isebenze ekunciphiseni iintlungu nokungonwabi.
Iziphumo zokulwa nokuvuvukala:I-Rotundine ibonakalise iimpawu zokulwa nokuvuvukala, ezinokunceda ekunciphiseni ukudumba kunye neempawu ezinxulumene noko.
Ukuphumla kunye nokuthomalalisa:I-Rotundine isetyenziselwe ukukhuthaza ukuphumla kunye nokuthomalalisa, nto leyo eyenza ukuba ibe luncedo ekulawuleni uxinzelelo kunye nokuxhalaba.
Umsebenzi we-antioxidant:Kufunyenwe ukuba iRotundine ineempembelelo ze-antioxidant, ezinokunceda ukukhusela iiseli kumonakalo obangelwa zii-free radicals.
Amathuba onyango lokuxhomekeka:Olunye uphando lubonisa ukuba iRotundine inokuba nakho ukulawula iimpawu zokulutha kunye nokurhoxa, ingakumbi kubantu abaxhomekeke kwi-opioid.
Iingenelo zesisu:I-Rotundine ifundwe ngenxa yokuba inamandla okunciphisa iingxaki zesisu, ezifana nokuqaqamba kunye nokungonwabi.
| Uhlalutyo | Inkcazo |
| Uvavanyo | I-Tetrahydropalmatine ≥98% |
| Inkangeleko | Umgubo otyheli okhanyayo ukuya kumhlophe |
| Uthuthu | ≤0.5% |
| Ukufuma | ≤5.0% |
| Izibulali-zinambuzane | Okungalunganga |
| Iintsimbi ezinzima | ≤10ppm |
| Pb | ≤2.0ppm |
| As | ≤2.0ppm |
| Ivumba elibi | Uphawu |
| Ubungakanani besuntswana | I-100% ukuya kwi-80 mesh |
| Izinto ezibangela iintsholongwane: | |
| Iibhaktheriya zizonke | ≤1000cfu/g |
| Iifungi | ≤100cfu/g |
| ISalmgosella | Okungalunganga |
| I-Coli | Okungalunganga |
I-Rotundine inezicelo kumashishini aliqela, kuquka:
Ishishini leMithi:I-Rotundine isetyenziswa kwishishini lamayeza ngenxa yeempawu zayo zokuthomalalisa iintlungu, ukuthomalalisa, kunye nokuxhalaba. Ingafakwa kumayeza okulawula iintlungu kunye nokunciphisa ixhala.
Ukhathalelo lwempilo kunye nokuphila kakuhle:Ngenxa yeenzuzo zayo zempilo ezixeliweyo, iRotundine ingasetyenziswa kwiimveliso zonyango kunye nempilo-ntle ezijolise ekukhuthazeni ukuphumla nokulawula iintlungu.
Uphando nophuhliso:I-Rotundine inomdla kwimizamo yophando nophuhliso egxile kwimpilo yentliziyo, unyango lomhlaza, kunye neemeko zemithambo-luvo ngenxa yeziphumo zayo ezixeliweyo kwezi nkqubo.
Izakhamzimba:Kukho ithuba lokufakwa kweRotundine kwiimveliso ze-nutraceutical ezenzelwe ukuxhasa impilo-ntle iyonke.
Kubalulekile ukuqaphela ukuba usetyenziso oluthile lweRotundine lunokwahluka ngokusekwe kwiimvume zomthetho kunye nophando oluqhubekayo kwishishini ngalinye.
Iimveliso zethu zenziwa kusetyenziswa amanyathelo olawulo lomgangatho angqongqo kwaye zilandela imigangatho ephezulu yeenkqubo zemveliso. Sibeka phambili ukhuseleko kunye nomgangatho wemveliso yethu, siqinisekisa ukuba iyahlangabezana neemfuno zomthetho kunye neziqinisekiso zoshishino. Oku kuzibophelela kumgangatho kujolise ekusekeni ukuthembana kunye nokuzithemba ekuthembekeni kwemveliso yethu. Inkqubo yemveliso ngokubanzi yile ilandelayo:
Indawo yokugcina:Gcina kwindawo epholileyo, eyomileyo, necocekileyo, Khusela ukufuma kunye nokukhanya okuthe ngqo.
Iphakheji enkulu:20~25kg/idrama.
Ixesha lokukhokhela:Iintsuku ezisi-7 emva kweodolo yakho.
Beka ubomi kwishelufa:iminyaka eyi-2.
Ingxelo:Iinkcukacha ezenziwe ngokwezifiso zinokufezekiswa.
Express
Ngaphantsi kwe-100kg, iintsuku ezi-3-5
Inkonzo yokungena emnyango kulula ukuyithatha impahla
Ngaselwandle
Ngaphezulu kwe-300kg, malunga neentsuku ezingama-30
Kufuneka umthengisi weenkonzo zokucoca iinqanawa ukusuka kwelinye izibuko ukuya kwelinye
Ngomoya
100kg-1000kg, iintsuku ezi-5-7
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