I-Methyltetrahydrofolate Calcium ecocekileyo (5MTHF-Ca)
I-Methyltetrahydrofolate ecocekileyo I-Calcium (5-MTHF-Ca) luhlobo lwe-folate olufumaneka kakhulu kwi-bio kwaye lunokusetyenziswa lula ngumzimba. Yityuwa ye-calcium ye-methyltetrahydrofolate, oluluhlobo olusebenzayo lwe-folate emzimbeni. I-Folate yi-vitamin B ebalulekileyo edlala indima ebalulekileyo kwiinkqubo ezahlukeneyo zeseli, kubandakanya ukwenziwa kwe-DNA, ukuveliswa kweeseli ezibomvu zegazi, kunye nomsebenzi wenkqubo yemithambo-luvo.
I-MTHF-Ca idla ngokusetyenziswa njengesongezelelo sokutya ukuxhasa amanqanaba e-folate kubantu abanokuba nobunzima bokucola okanye ukufunxa uhlobo lwe-folic acid olufumaneka ekutyeni okuqinisiweyo kunye nezongezo. Iluncedo ngakumbi kubantu abaneenguqu ezithile zemfuza ezinokuphazamisa imetabolism ye-folate.
Ukongeza i-MTHF-Ca kunokunceda ukuxhasa impilo-ntle iyonke, ngakumbi kwiindawo ezifana nempilo yentliziyo, uphuhliso lwetyhubhu ye-neural ngexesha lokukhulelwa, ukusebenza kwengqondo, kunye nokulawula imood. Kubalulekile ukuqaphela ukuba i-MTHF-Ca kufuneka isetyenziswe phantsi kwesikhokelo sengcali yezempilo, ngakumbi kubantu abaneengxaki ezithile zempilo okanye abo bathatha amayeza athile.
| Igama lemveliso： | I-L-5-Methyltetrahydrofolate calcium |
| Izithethantonye： | i-calcium ye-6S-5-Methyltetrahydrofolate; i-calcium ye-L-5-Methyltetrahydrofolate; i-calcium ye-Levomefolate |
| Ifomula yeMolekyuli: | C20H23CaN7O6 |
| Ubunzima beemolekyuli: | 497.52 |
| Inombolo ye-CAS: | 151533-22-1 |
| Umxholo: | ≥ 95.00% yi-HPLC |
| Inkangeleko: | Umgubo wekristali omhlophe ukuya kotyheli okhanyayo |
| Ilizwe lemveli: | iTshayina |
| Iphakheji: | 20kg/idrama |
| Beka ubomi kwishelufa: | Iinyanga ezingama-24 |
| Indawo yokugcina: | Gcina kwindawo epholileyo neyomileyo. |
| Izinto | Iinkcukacha | Iziphumo |
| Inkangeleko | Umgubo omhlophe okanye omhlophe qhwa | Qinisekisa |
| Ukuchongwa | Elungileyo | Qinisekisa |
| I-calcium | 7.0% - 8.5% | 8.4% |
| I-D-5-Methylfolate | ≤1.0 | Ayifunyaniswanga |
| Intsalela ekutshisweni | ≤0.5% | 0.01% |
| Amanzi | ≤17.0% | 13.5% |
| Uvavanyo (HPLC) | 95.0% -102.0% | 99.5% |
| Uthuthu | ≤0.1% | 0.05% |
| Intsimbi enzima | ≤20 ppm | Qinisekisa |
| Inani Lilonke Leepleyiti | ≤1000cfu/g | Abafanelekileyo |
| Imvubelo kunye noMbungu | ≤100cfu/g | Abafanelekileyo |
| I-E.coil | Okungalunganga | Okungalunganga |
| I-Salmonella | Okungalunganga | Okungalunganga |
Ukufumaneka okuphezulu kwe-bioavailability:I-MTHF-Ca luhlobo lwe-folate olufumaneka lula kwi-bioavailability, nto leyo ethetha ukuba inokufunxwa kwaye isetyenziswe ngumzimba ngokulula. Oku kubalulekile kuba abanye abantu banokuba nobunzima bokuguqula i-folic acid yokwenziwa ibe yimo yayo esebenzayo.
Uhlobo olusebenzayo lwe-folate:I-MTHF-Ca yindlela esebenzayo ye-folate, eyaziwa ngokuba yi-methyltetrahydrofolate. Le ndlela isetyenziswa lula ngumzimba kwaye ayifuni naziphi na iinkqubo ezongezelelweyo zokuguqula.
Ityuwa yeCalcium:I-MTHF-Ca yityuwa ye-calcium, oko kuthetha ukuba ibotshelelwe kwi-calcium. Oku kubonelela ngenzuzo eyongezelelweyo yokongezwa kwe-calcium kunye nenkxaso ye-folate. I-calcium ibalulekile kwimpilo yamathambo, ukusebenza kwemisipha, ukudluliselwa kwemithambo-luvo, kunye neminye imisebenzi yomzimba.
Ifanelekile kubantu abanezakhi zofuzo ezithile:I-MTHF-Ca iluncedo kakhulu kubantu abaneenguqu ezithile zemfuza ezinokuthi ziphazamise imetabolism ye-folate. Olu tshintsho lwemfuza lunokuchaphazela amandla omzimba okuguqula i-folic acid ibe yimo yayo esebenzayo, nto leyo eyenza ukuba ukongeza i-folate esebenzayo kube yimfuneko.
Ixhasa iinkalo ezahlukeneyo zempilo:Ukongezwa kwe-MTHF-Ca kunokuxhasa impilo yonke kunye nokuphila kakuhle. Kuluncedo ngakumbi kwimpilo yentliziyo, uphuhliso lwetyhubhu ye-neural ngexesha lokukhulelwa, ukusebenza kwengqondo, kunye nokulawula imood.
I-Methyltetrahydrofolate Calcium ecocekileyo (MTHF-Ca) inezibonelelo ezininzi zempilo:
Inkxaso ye-folate metabolism:I-MTHF-Ca luhlobo lwe-folate olufumaneka kakhulu kwi-bioall and active. Inceda ukuxhasa i-metabolism ye-folate yomzimba, ebalulekileyo ekuqulunqweni kwe-DNA, ukuveliswa kweeseli ezibomvu zegazi, kunye nokusebenza kweeseli ngokubanzi.
Impilo yentliziyo nemithambo yegazi:Amanqanaba aneleyo e-folate abalulekile kwimpilo yentliziyo. Ukongezwa kwe-MTHF-Ca kunokunceda ukunciphisa amanqanaba e-homocysteine, i-amino acid ethi, xa iphakanyisiwe, inxulunyaniswe nomngcipheko ophezulu wesifo sentliziyo.
Inkxaso yokukhulelwa:I-MTHF-Ca ibalulekile ngexesha lokukhulelwa, njengoko inceda ekuthinteleni iziphene ze-neural tube kwiintsana ezisakhulayo. Kucetyiswa ukuba abafazi abakwiminyaka yokuzala baqinisekise ukuba banamanqanaba aneleyo e-folate, ingakumbi ngexesha lokukhulelwa.
Ulawulo lweemvakalelo:I-folate idlala indima ebalulekileyo ekuhlanganisweni kwee-neurotransmitter. Amanqanaba aneleyo e-folate axhasa ukuveliswa kwe-serotonin, i-dopamine, kunye ne-norepinephrine, ezibalulekileyo ekulawuleni imood. Ukongezwa kwe-MTHF-Ca kunokuba luncedo kubantu abaneengxaki zemood, ezifana nokudakumba.
Umsebenzi wokuqonda:I-folate ibalulekile ekusebenzeni kwengqondo nakwimpilo yengqondo. Ukongezwa kwe-MTHF-Ca kunokuxhasa inkumbulo, ukugxila, kunye nokusebenza kwengqondo iyonke, ingakumbi kubantu abadala.
Inkxaso yesondlo:Ukongezwa kwe-MTHF-Ca kunokuba luncedo kubantu abanezakhi zofuzo ezahlukeneyo ezichaphazela imetabolism ye-folate. Aba bantu banokuba nobunzima bokuguqula i-folic acid yokwenziwa ibe yimo yayo esebenzayo. I-MTHF-Ca ibonelela ngohlobo olusebenzayo lwe-folate ngokuthe ngqo, idlula naziphi na iingxaki zokuguqulwa.
Izakhamzimba kunye nezongezo zokutya:I-MTHF-Ca isetyenziswa kakhulu njengesithako esibalulekileyo kwizongezo zesondlo kunye ne-nutraceuticals. Ibonelela ngohlobo lwe-folate olufumaneka kakhulu kwi-bio, olubonelela ngeenzuzo ezininzi zempilo, njengoko bekutshiwo ngaphambili.
Ukomeleza ukutya neziselo:I-MTHF-Ca ingafakwa kwiimveliso zokutya neziselo ukuze ziqiniswe nge-folate. Oku kubaluleke kakhulu kwiimveliso ezilungiselela abantu abane-folate enqongopheleyo okanye iimfuno eziphezulu ze-folate, njengabasetyhini abakhulelweyo okanye abantu abaneengxaki ezithile zempilo.
Iifomyula zamayeza:I-MTHF-Ca ingasetyenziswa kwiifomyula zamayeza njengesithako esisebenzayo. Ingasetyenziswa kumayeza ajolise kwiimeko ezithile ezinxulumene nokungabikho kwe-folate okanye ukungasebenzi kakuhle kwe-folate metabolism, njenge-anemia okanye iingxaki ezithile zemfuza.
Ukhathalelo lomntu kunye nezinto zokuthambisa:I-MTHF-Ca ngamanye amaxesha ifakwa kwiimveliso zokhathalelo lomntu kunye nezinto zokuthambisa ngenxa yeengenelo zayo ezinokubakho kwimpilo yolusu. I-Folate ibandakanyeka kwiinkqubo ezahlukeneyo zeeseli zolusu kwaye inokuba negalelo kwimpilo yalo iyonke kunye nenkangeleko yalo.
Ukutya kwezilwanyana:I-MTHF-Ca ingafakwa nakwisondlo sezilwanyana ukuze yongeze izilwanyana nge-folate. Oku kubaluleke kakhulu kwimizi-mveliso yemfuyo kunye neenkukhu, apho ukuqinisekisa ukutya okwaneleyo ukuze kukhule kakuhle kwaye kube sempilweni kubalulekile.
Ezi ndawo zokusetyenziswa zibonisa ukuguquguquka kwe-MTHF-Ca kunye nokusetyenziswa kwayo kumashishini ahlukeneyo ukujongana neengxaki zempilo ezinxulumene ne-folate kunye neemfuno zesondlo. Nangona kunjalo, kubalulekile ukulandela izikhokelo ezifanelekileyo zomthamo kunye nokubonisana neengcali xa ufaka i-MTHF-Ca kuyo nayiphi na imveliso okanye umxube.
Ukufunyanwa kwezinto eziluhlaza:Le nkqubo iqala ngokukhangela izinto ezisemgangathweni ophezulu. Izinto ezifunekayo ekuveliseni i-MTHF-Ca yi-folic acid kunye ne-calcium salts.
Ukuguqulwa kwe-folic acid ibe yi-5,10-Methylenetetrahydrofolate (5,10-MTHF):I-folic acid iguqulwa ibe yi-5,10-MTHF ngenkqubo yokunciphisa. Eli nyathelo lidla ngokubandakanya ukusetyenziswa kwezinto ezinciphisayo ezifana ne-sodium borohydride okanye ezinye izinto ezifanelekileyo zokunciphisa izicubu.
Ukuguqulwa kwe-5,10-MTHF ibe yi-MTHF-Ca:I-5,10-MTHF iphinda ixutywe netyuwa ye-calcium efanelekileyo, efana ne-calcium hydroxide okanye i-calcium carbonate, ukuze yenze i-Methyltetrahydrofolate Calcium (MTHF-Ca). Le nkqubo ibandakanya ukuxuba ii-reactants nokuzivumela ukuba zenze phantsi kweemeko ezilawulwayo, kubandakanya ubushushu, i-pH, kunye nexesha lokuphendula.
Ukucocwa kunye nokuhluzwa:Emva kwempendulo, isisombululo se-MTHF-Ca sidlula kwiinkqubo zokucoca ezifana nokucoca, ukucocwa kwe-centrifugation, okanye ezinye iindlela zokwahlula ukususa ukungcola kunye neemveliso ezinokuba zenziwe ngexesha lempendulo.
Ukomisa nokuqinisa:Isisombululo se-MTHF-Ca esicociweyo siyacutshungulwa ukuze kususwe umswakama ogqithisileyo kwaye kuqiniswe imveliso yokugqibela. Oku kunokufezekiswa ngeendlela ezifana nokomisa ngokutshiza okanye ukomisa ngokukhenkceza, kuxhomekeke kwifom yemveliso oyifunayo.
Ulawulo lomgangatho kunye novavanyo:Imveliso yokugqibela ye-MTHF-Ca ilawulwa ngamanyathelo angqongqo okulawula umgangatho ukuqinisekisa ubunyulu bayo, uzinzo, kunye nokunamathela kwimigangatho yomgangatho echaziweyo. Oku kungabandakanya ukuvavanywa kokungcola, amandla, kunye nezinye iiparameter ezifanelekileyo.
Ukupakishwa kunye nokugcinwa:I-MTHF-Ca ipakishwe kwiikhonteyina ezifanelekileyo, iqinisekisa ukuba iilebhile ezifanelekileyo kunye neemeko zokugcina ukuze ihlale iqinile kwaye izinzile. Ihlala igcinwa kwindawo eyomileyo, epholileyo kude nelanga elithe ngqo.
Indawo yokugcina: Gcina kwindawo epholileyo, eyomileyo, necocekileyo, Khusela ukufuma kunye nokukhanya okuthe ngqo.
Iphakheji enkulu: 25kg/idrama.
Ixesha lokuKhokhela: Iintsuku ezisi-7 emva kweodolo yakho.
Ubomi beShelufu: Iminyaka emi-2.
Phawula: Iinkcukacha ezenziwe ngokwezifiso nazo zinokufezekiswa.
20kg/ibhegi 500kg/ipalethi
Ukupakisha okuqinisiweyo
Ukhuseleko lwezothutho
Express
Ngaphantsi kwe-100kg, iintsuku ezi-3-5
Inkonzo yokungena emnyango kulula ukuyithatha impahla
Ngaselwandle
Ngaphezulu kwe-300kg, malunga neentsuku ezingama-30
Kufuneka umthengisi weenkonzo zokucoca iinqanawa ukusuka kwelinye izibuko ukuya kwelinye
Ngomoya
100kg-1000kg, iintsuku ezi-5-7
Kufuneka umthengisi weenkonzo zokucoca izikhululo zeenqwelo-moya ukusuka kwisikhululo seenqwelo-moya ukuya kwisikhululo seenqwelo-moya
I-Methyltetrahydrofolate Calcium ecocekileyo (5-MTHF-Ca)iqinisekisiwe ngesatifikethi se-ISO, isatifikethi se-HALAL, kunye nesatifikethi se-KOSHER.
Umahluko phakathi kwesizukulwana sesine se-folic acid (5-MTHF) kunye ne-folic acid yendabuko usekwe kwisakhiwo sazo seekhemikhali kunye nokufumaneka kwazo emzimbeni.
Ulwakhiwo lweekhemikhali:I-folic acid yendabuko luhlobo lwe-folate oluyilwe ngendlela yokwenziwa olufuna ukugqitha amanyathelo amaninzi okuguqula umzimba ngaphambi kokuba lusetyenziswe. Kwelinye icala, i-folic acid yesizukulwana sesine, eyaziwa ngokuba yi-5-MTHF okanye i-Methyltetrahydrofolate, luhlobo olusebenzayo nolufumanekayo lwe-folate olungadingi ukuguqulwa.
Ukufumaneka kwezinto eziphilayo:I-folic acid yendabuko kufuneka iguqulwe ibe yimo yayo esebenzayo, i-5-MTHF, ngokusebenzisa ii-enzyme reactions emzimbeni. Le nkqubo yokuguqulwa iyahluka phakathi kwabantu kwaye inokuchatshazelwa kukutshintsha kwezakhi zofuzo okanye ezinye izinto. Ngokwahlukileyo koko, i-5-MTHF sele ikwimo yayo esebenzayo, nto leyo eyenza ukuba ifumaneke lula ukuze isetyenziswe kwiiseli.
Ukufunxwa nokusetyenziswa:Ukufunxwa kwe-folic acid yendabuko kwenzeka emathunjini amancinci, apho kufuneka iguqulwe ibe yifom esebenzayo yi-enzyme dihydrofolate reductase (DHFR). Nangona kunjalo, le nkqubo yokuguqula ayisebenzi kakuhle kwabanye abantu, nto leyo ekhokelela ekufumanekeni okuphantsi kwe-bioavailability. I-5-MTHF, ekubeni yifom esebenzayo, ifunxwa kwaye isetyenziswa ngumzimba ngokulula, idlula inkqubo yokuguqula. Oku kuyenza ibe yifom ekhethwayo kubantu abaneenguqu zemfuza okanye iimeko ezichaphazela imetabolism ye-folate.
Ukufaneleka kwabantu abathile:Ngenxa yokwahluka kokufunxwa nokusetyenziswa, i-5-MTHF ithathwa njengefanelekileyo ngakumbi kubantu abaneenguqu ezithile zemfuza, ezifana nokuguqulwa kwezakhi zofuzo ze-MTHFR, ezinokuthi ziphazamise ukuguqulwa kwe-folic acid kwimo yayo esebenzayo. Kwaba bantu, ukusebenzisa i-5-MTHF ngokuthe ngqo kunokuqinisekisa amanqanaba afanelekileyo e-folate emzimbeni kwaye kuxhase imisebenzi eyahlukeneyo yebhayoloji.
Isongezelelo:I-folic acid yesintu ixhaphake kakhulu kwizongezo, ukutya okuqinisiweyo, kunye nokutya okucutshungulwayo, njengoko izinzile kwaye ingabizi kakhulu ukuyivelisa. Nangona kunjalo, kukho ukufumaneka okukhulayo kwezongezo ze-5-MTHF ezibonelela ngohlobo olusebenzayo ngokuthe ngqo, olunokuba luncedo kubantu abanobunzima bokuguqula i-folic acid.
Iziphumo ebezingalindelekanga ze-folic acid yesizukulwana sesine (5-MTHF) zihlala zinqabile kwaye zincinci, kodwa kubalulekile ukuqaphela iimpendulo ezinokubakho:
Iimpendulo ze-allergy:Njengayo nayiphi na isongezelelo okanye amayeza, iimpembelelo ze-allergic zinokwenzeka. Iimpawu zingabandakanya ukurhawuzelela, ukurhawuzelela, ukudumba, isiyezi, okanye ubunzima bokuphefumla. Ukuba ufumana naziphi na kwezi mpawu, funa uncedo lwezonyango ngokukhawuleza.
Iingxaki zokugaya ukutya:Abanye abantu banokufumana ukungakhululeki esiswini, okufana nokucaphuka, ukudumba, igesi, okanye urhudo. Ezi mpawu zihlala ziphela njengoko umzimba uqhelana nesongezo.
Ukusebenzisana namayeza:I-5-MTHF isenokusebenzisana namayeza athile, kuquka amayeza asetyenziselwa unyango lomhlaza, amayeza okuxhuzula, i-methotrexate, kunye namayeza athile okubulala iintsholongwane. Kubalulekile ukuthetha nomboneleli wakho wezempilo ukuba uthatha nawaphi na amayeza ukuqinisekisa ukuba akukho ntsebenziswano inokwenzeka.
Amanqanaba e-overdose okanye amanqanaba e-folate agqithisileyo:Nangona kunqabile, ukutya i-folate kakhulu (kuquka i-5-MTHF) kunokukhokelela kumanqanaba aphezulu e-folate egazini. Oku kusenokufihla iimpawu zokunqongophala kwe-vitamin B12 kwaye kuchaphazele ukuxilongwa kunye nonyango lweemeko ezithile. Kubalulekile ukulandela idosi ecetyiswayo kwaye udibane nogqirha ukuze ufumane isikhokelo.
Ezinye izinto ekufuneka uziqwalasele:Abafazi abakhulelweyo okanye abo baceba ukukhulelwa kufuneka bathethe nomboneleli wabo wezempilo ngaphambi kokuba bathathe iidosi eziphezulu ze-5-MTHF, njengoko ukutya i-folate eninzi kunokuzifihla iimpawu zokungabikho kwe-vitamin B12, ebalulekileyo ekuphuhlisweni kwetyhubhu ye-neural kwimveku.
Njengakwezinye izongezo zokutya okanye amayeza, kubalulekile ukuxoxa ngokusetyenziswa kwe-folic acid yesizukulwana sesine (5-MTHF) nomboneleli wezempilo, ingakumbi ukuba uneengxaki zempilo ezifihlakeleyo okanye uthatha amanye amayeza. Banokubonelela ngeengcebiso zomntu ngamnye ngokusekelwe kwiimfuno zakho ezithile kwaye bancede ekujongeni naziphi na iziphumo ebezingalindelekanga.
I-folic acid yesizukulwana sesine, ekwaziwa ngokuba yi-5-methyltetrahydrofolate (5-MTHF), luhlobo lwe-folate olusebenzayo ngokwebhayoloji olufunxwa kwaye lusetyenziswa lula ngumzimba xa kuthelekiswa nokongezwa kwe-folic acid yendabuko. Nazi ezinye izifundo zesayensi ezixhasa ukusebenza kwayo:
Ukwanda kokufumaneka kwezinto eziphilayo:I-5-MTHF ibonakalisiwe ukuba inokufumaneka kakhulu kwi-bioavailability kune-folic acid. Uphononongo olupapashwe kwi-American Journal of Clinical Nutrition luthelekise ukufumaneka kwe-folic acid kunye ne-5-MTHF kwi-bioavailability kubasetyhini abasempilweni. Lufumanise ukuba i-5-MTHF yayifunxwa ngokukhawuleza kwaye ikhokelele kumanqanaba aphezulu e-folate kwiiseli ezibomvu zegazi.
Imeko ye-folate ephuculweyo:Izifundo ezininzi zibonise ukuba ukongezwa kwe-5-MTHF kunokunyusa ngempumelelo amanqanaba e-folate egazini. Kwilingo elilawulwa ngokungacwangciswanga elipapashwe kwiJournal of Nutrition, abaphandi bathelekise imiphumo yokongezwa kwe-5-MTHF kunye ne-folic acid kwimeko ye-folate kubasetyhini abasempilweni. Bafumanise ukuba i-5-MTHF yayisebenza ngakumbi ekwandiseni amanqanaba e-folate eeseli ezibomvu zegazi kune-folic acid.
Ukuphuculwa kwe-metabolism ye-folic acid:I-5-MTHF ibonakalisiwe ukuba iyawadlula amanyathelo e-enzyme afunekayo ukuze kusebenze i-folic acid kwaye ithathe inxaxheba ngokuthe ngqo kwi-metabolism ye-folic acid yeselula. Uphononongo olupapashwe kwiJournal of Nutrition and Metabolism lubonise ukuba ukongezwa kwe-5-MTHF kuphucula imetabolism ye-folate yangaphakathi kweseli kubantu abaneenguqu zemfuza kwii-enzymes ezibandakanyeka ekusebenzeni kwe-folic acid.
Amanqanaba e-homocysteine anciphileyo:Amanqanaba aphezulu e-homocysteine, i-amino acid egazini, anxulunyaniswa nomngcipheko ophezulu wezifo zentliziyo. Izifundo zibonise ukuba ukongezwa kwe-5-MTHF kunokunciphisa ngempumelelo amanqanaba e-homocysteine. Uhlalutyo olupapashwe kwi-meta-analysis olupapashwe kwi-Journal of the American College of Nutrition luhlalutye iimvavanyo ezingama-29 ezilawulwa ngokungacwangciswanga kwaye lwagqiba kwelokuba ukongezwa kwe-5-MTHF kusebenze ngakumbi kune-folic acid ekunciphiseni amanqanaba e-homocysteine.
Kubalulekile ukuqaphela ukuba iimpendulo zomntu ngamnye kwi-supplementation zinokwahluka, kwaye ukusebenza kwe-5-MTHF kunokuxhomekeka kwizinto ezifana nokwahluka kwezakhi zofuzo kwi-enzymes ye-folate metabolism kunye nokutya ngokubanzi. Kucetyiswa rhoqo ukuba udibane nomboneleli wezempilo ukuze ufumane ingcebiso eyimfihlo malunga ne-supplementation kunye nokuxoxa ngayo nayiphi na inkxalabo okanye iimeko ezithile zempilo.
