I-Methyltetrahydrofolate ecocekileyo yeCalcium (5MTHF-Ca)
I-Methyltetrahydrofolate ecocekileyo yeCalcium (5-MTHF-Ca) luhlobo lwe-folate olufumaneka kakhulu kwi-bioavailable kwaye lunokusetyenziswa lula ngumzimba.Ityuwa ye-calcium ye-methyltetrahydrofolate, yindlela esebenzayo ye-folate emzimbeni.I-Folate yivithamin ye-B ebalulekileyo edlala indima ebalulekileyo kwiinkqubo ezahlukeneyo zeselula, kubandakanya ukuhlanganiswa kwe-DNA, ukuveliswa kweeseli ezibomvu zegazi, kunye nokusebenza kwenkqubo yemithambo-luvo.
I-MTHF-Ca isoloko isetyenziswa njengesongezelelo sokutya ukuxhasa amanqanaba efolate kubantu abanokuba nobunzima bokwenza imetabolize okanye ukufunxa uhlobo lokwenziwa lwe-folic acid efumaneka kukutya okongeziweyo kunye nezongezelelo.Iluncedo ngakumbi kubantu abaneenguqu ezithile zemfuza ezinokuphazamisa i-folate metabolism.
Ukongezwa nge-MTHF-Ca kunokunceda ukuxhasa impilo yonke kunye nokuphila kakuhle, ngakumbi kwiindawo ezifana nempilo yentliziyo, uphuhliso lwe-neural tube ngexesha lokukhulelwa, ukusebenza kwengqondo, kunye nokulawulwa kweemvakalelo.Kubalulekile ukuqaphela ukuba i-MTHF-Ca kufuneka isetyenziswe phantsi kwesikhokelo sokhathalelo lwempilo, ngakumbi kubantu abaneemeko ezithile zonyango okanye abo bathatha amayeza athile.
| Igama lemveliso: | I-L-5-Methyltetrahydrofolate calcium |
| Izithethantonye: | I-6S-5-Methyltetrahydrofolate calcium;I-Calcium L-5-Methyltetrahydrofolate;Levomefolate calcium |
| Ifomula yemolekyuli: | I-C20H23CaN7O6 |
| Ubunzima beMolekyuli: | 497.52 |
| Inombolo yeCAS: | 151533-22-1 |
| Umxholo: | ≥ 95.00% yi-HPLC |
| Imbonakalo: | Umgubo wekristale omhlophe ukuya kumthubi |
| Ilizwe lemveli: | eTshayina |
| Umqulu: | 20kg/igubu |
| Beka ubomi kwishelufa: | Iinyanga ezingama-24 |
| Ugcino: | Gcina kwindawo epholileyo & eyomileyo. |
| Izinto | Iinkcukacha | Iziphumo |
| Imbonakalo | Umgubo omhlophe okanye omhlophe | Qinisekisa |
| Ukuchongwa | Okuhle | Qinisekisa |
| Icalcium | 7.0%-8.5% | 8.4% |
| D-5-Methylfolate | ≤1.0 | Ayifunyaniswanga |
| Intsalela ekutshisweni | ≤0.5% | 0.01% |
| Amanzi | ≤17.0% | 13.5% |
| Uvavanyo(HPLC) | 95.0%-102.0% | 99.5% |
| Uthuthu | ≤0.1% | 0.05% |
| Intsimbi enzima | ≤20 ppm | Qinisekisa |
| Ubalo lwePleti luphelele | ≤1000cfu/g | Ufanelekile |
| Igwele&Mngundo | ≤100cfu/g | Ufanelekile |
| E.coil | Ibi | Ibi |
| Salmonella | Ibi | Ibi |
I-bioavailability ephezulu:I-MTHF-Ca luhlobo lwe-folate olufumaneka lula kakhulu, nto leyo ethetha ukuba inokufunxwa lula kwaye isetyenziswe ngumzimba.Oku kubalulekile kuba abanye abantu banokuba nobunzima ekuguquleni i-synthetic folic acid ibe yimo esebenzayo.
Uhlobo olusebenzayo lwe-folate:I-MTHF-Ca yindlela esebenzayo ye-folate, eyaziwa ngokuba yi-methyltetrahydrofolate.Le fom isetyenziswa ngokulula ngumzimba kwaye ayifuni naziphi na iinkqubo zokuguqula ezongezelelweyo.
Ityuwa yeCalcium:I-MTHF-Ca yityuwa ye-calcium, nto leyo ethetha ukuba ibotshelelwe kwi-calcium.Oku kubonelela ngenzuzo eyongezelelweyo ye-calcium supplementation kunye nenkxaso ye-folate.I-calcium ibalulekile kwimpilo yamathambo, ukusebenza kwemisipha, ukuhanjiswa kwemithambo-luvo, kunye neminye imisebenzi yomzimba.
Ilungele abantu abaneenguqu ezithile zofuzo:I-MTHF-Ca iluncedo kakhulu kubantu abaneenguqu ezithile zemfuza ezinokuphazamisa i-folate metabolism.Olu tshintsho lwemfuza lunokuchaphazela amandla omzimba wokuguqula i-folic acid ibe yifom esebenzayo, ukwenza ukongezwa nge-folate esebenzayo kuyimfuneko.
Ixhasa imiba eyahlukeneyo yezempilo:Ukuxhaswa kwe-MTHF-Ca kunokuxhasa impilo yonke kunye nokuphila kakuhle.Kuyinzuzo ngakumbi kwimpilo ye-cardiovascular, uphuhliso lwe-neural tube ngexesha lokukhulelwa, umsebenzi wokuqonda, kunye nokulawulwa kwemizwelo.
I-Methyltetrahydrofolate Calcium enyulu (MTHF-Ca) ibonelela ngeenzuzo ezininzi zempilo:
Inkxaso ye-folate metabolism:I-MTHF-Ca yindlela efumaneka kakhulu kwi-bioavailable kwaye esebenzayo ye-folate.Inceda ukuxhasa i-folate metabolism yomzimba, ebaluleke kakhulu kwi-DNA synthesis, ukuveliswa kweeseli ezibomvu zegazi, kunye nokusebenza ngokubanzi kweeseli.
Impilo yentliziyo:Amanqanaba aneleyo e-folate ayimfuneko kwimpilo yentliziyo.Ukuxhaswa kwe-MTHF-Ca kunokunceda ukunciphisa amanqanaba e-homocysteine, i-amino acid ethi, xa iphakanyisiwe, idibaniswe nomngcipheko wokwanda kwesifo senhliziyo.
Inkxaso yokukhulelwa:I-MTHF-Ca ibalulekile ngexesha lokukhulelwa, njengoko inceda ukuthintela iziphene ze-neural tube ekuphuhliseni abantwana.Kuyacetyiswa kubasetyhini abakwiminyaka yokuzala ukuba baqinisekise ukuba banamanqanaba aneleyo e-folate, ngakumbi kumanqanaba okuqala okukhulelwa.
Ukulawula imo:I-Folate idlala indima ebalulekileyo kwi-neurotransmitter synthesis.Amanqanaba afanelekileyo e-folate axhasa ukuveliswa kwe-serotonin, i-dopamine, kunye ne-norepinephrine, ebalulekileyo ekulawuleni isimo sengqondo.Ukuxhaswa kwe-MTHF-Ca kunokuba luncedo kubantu abanengxaki yeemvakalelo, njengokudakumba.
Umsebenzi wokuqonda:I-Folate ibalulekile ekusebenzeni kwengqondo kunye nempilo yengqondo.Ukuxhaswa kwe-MTHF-Ca kunokuxhasa inkumbulo, ukugxila, kunye nokusebenza kwengqondo ngokubanzi, ngakumbi kubantu abadala.
Inkxaso yesondlo:Ukuxhaswa kwe-MTHF-Ca kunokuba luncedo kubantu abaneenguqu zofuzo ezichaphazela i-folate metabolism.Aba bantu banokuba nobunzima ekuguquleni i-synthetic folic acid ibe yimo esebenzayo.I-MTHF-Ca ibonelela ngendlela esebenzayo yefolate ngokuthe ngqo, idlula kuyo nayiphi na imiba yokuguqulwa.
Nutraceuticals kunye nezongezo zokutya:I-MTHF-Ca iqhele ukusetyenziswa njengesithako esiphambili kwizongezo zesondlo kunye nezondlo.Ibonelela ngefolate efumaneka kakhulu ngebhayoloji, ebonelela ngeenzuzo ezininzi zempilo, njengoko bekutshiwo ngaphambili.
Ukuqinisa ukutya kunye nesiselo:I-MTHF-Ca inokufakwa kwiimveliso zokutya kunye neziselo ukuze zomeleze nge-folate.Oku kubaluleke ngakumbi kwiimveliso ezibonelela abantu abanengxaki ye-folate okanye ukwanda kweemfuno ze-folate, njengabasetyhini abakhulelweyo okanye abantu abaneemeko ezithile zempilo.
Imixube yamayeza:I-MTHF-Ca ingasetyenziswa kwimixube yamayeza njengesithako esisebenzayo.Ingasetyenziswa kumayeza ajolise kwiimeko ezithile ezinxulumene nokusilela kwe-folate okanye ukuphazamiseka kwe-folate metabolism, njenge-anemia okanye ukuphazamiseka okuthile kwemfuzo.
Ukhathalelo lomntu kunye nezinto zokuthambisa:I-MTHF-Ca ngamanye amaxesha ibandakanyiwe kwiimveliso zokhathalelo lomntu kunye nezithambiso ngenxa yeenzuzo zayo ezinokubakho kwimpilo yolusu.I-Folate ibandakanyeka kwiinkqubo ezahlukeneyo zeseli zolusu kwaye inokuba negalelo kwimpilo yayo yonke kunye nenkangeleko.
Ukutya kwezilwanyana:I-MTHF-Ca inokudityaniswa nokutya kwezilwanyana ukongeza kwizilwanyana ngefolate.Oku kubaluleke ngakumbi kwimizi-mveliso yemfuyo kunye neenkukhu, apho kufuneka kuqinisekiswe isondlo esaneleyo ukuze kukhule okugqibeleleyo nempilo kubalulekile.
Ezi nkalo zesicelo zibonisa ukuguquguquka kwe-MTHF-Ca kunye nokusetyenziswa kwayo kumashishini ahlukeneyo ukujongana neenkxalabo zempilo ezinxulumene ne-folate kunye neemfuno zesondlo.Nangona kunjalo, kubalulekile ukulandela izikhokelo ezifanelekileyo zedosi kwaye udibane neengcali xa ufaka i-MTHF-Ca kuyo nayiphi na imveliso okanye uqulunqo.
Ukufunwa kwemathiriyeli ekrwada:Inkqubo iqala ngokufunwa kwemathiriyeli ekrwada ekumgangatho ophezulu.Izinto ezisisiseko ezifunekayo kwimveliso ye-MTHF-Ca yi-folic acid kunye neetyuwa ze-calcium.
Ukuguqulwa kwe-folic acid kwi-5,10-Methylenetetrahydrofolate (5,10-MTHF):I-Folic acid iguqulwa ibe yi-5,10-MTHF ngenkqubo yokunciphisa.Eli nyathelo libandakanya ukusetyenziswa kwee-agent zokunciphisa ezifana ne-sodium borohydride okanye ezinye ii-catalysts ezifanelekileyo.
Uguqulo lwe-5,10-MTHF ukuya kwi-MTHF-Ca:I-5,10-MTHF iphinda iphendule ngetyuwa ye-calcium efanelekileyo, njenge-calcium hydroxide okanye i-calcium carbonate, ukwenza i-Methyltetrahydrofolate Calcium (MTHF-Ca).Le nkqubo ibandakanya ukuxuba i-reactants kwaye ibavumele ukuba baphendule phantsi kweemeko ezilawulwayo, kubandakanya ukushisa, i-pH, kunye nexesha lokuphendula.
Ukucocwa kunye nokuhluzwa:Emva kokusabela, isisombululo se-MTHF-Ca siqhuba iinkqubo zokucoca ezifana nokuhluzwa, i-centrifugation, okanye ezinye iindlela zokwahlula ukususa ukungcola kunye neemveliso ezinokuthi zenzeke ngexesha lokuphendula.
Ukomisa kunye nokuqina:Isisombululo se-MTHF-Ca esicociweyo siphinde siqhutywe ngakumbi ukususa ukufuma okugqithisileyo kunye nokuqinisa imveliso yokugqibela.Oku kunokufezekiswa ngobuchule obufana nokomisa isitshizi okanye ukomisa umkhenkce, kuxhomekeke kuhlobo lwemveliso olufunekayo.
Ulawulo lomgangatho kunye novavanyo:Imveliso yokugqibela ye-MTHF-Ca iphantsi kwemilinganiselo engqongqo yolawulo lomgangatho ukuqinisekisa ukucoceka kwayo, uzinzo, kunye nokubambelela kwimigangatho yomgangatho echaziweyo.Oku kunokubandakanya ukuvavanywa kokungcola, amandla, kunye nezinye iiparamitha ezifanelekileyo.
Ukupakishwa kunye nokugcinwa:I-MTHF-Ca ifakwe kwimigqomo efanelekileyo, iqinisekisa iileyibhile ezifanelekileyo kunye neemeko zokugcina ukugcina ingqibelelo kunye nokuzinza kwayo.Ngokuqhelekileyo igcinwa kwindawo eyomileyo, epholileyo kude nelanga elithe ngqo.
Ugcino: Gcina kwindawo epholileyo, eyomileyo, necocekileyo, Khusela kubumanzi nasekukhanyeni okuthe ngqo.
Iphakheji eninzi: 25kg / idrum.
Ixesha lokukhokela: Iintsuku ezi-7 emva komyalelo wakho.
Ubomi beShelf: iminyaka emi-2.
Phawula: Iinkcukacha ezilungiselelweyo nazo zinokufezekiswa.
20kg/bag 500kg/pallet
Ukupakishwa okuqiniweyo
Ukhuseleko lolungiselelo
Express
Ngaphantsi kwe-100kg, 3-5Days
Umnyango ukuya emnyango inkonzo lula ukuthatha iimpahla
Ngaselwandle
Ngaphezulu kwe-300kg, malunga neentsuku ezingama-30
Izibuko ukuya kwinkonzo yezibuko i-broker yobuchwephesha efunekayo
NgoMoya
100kg-1000kg, 5-7Days
Isikhululo seenqwelomoya ukuya kwinkonzo yesikhululo seenqwelomoya siyafuneka
I-Methyltetrahydrofolate ecocekileyo yeCalcium (5-MTHF-Ca)uqinisekiswe ngesatifikethi se-ISO, isatifikethi se-HALAL, kunye nesatifikethi se-KOSHER.
Umahluko phakathi kwesizukulwana sesine se-folic acid (i-5-MTHF) kunye ne-folic acid yendabuko ilele kulwakhiwo lwazo lweekhemikhali kunye nokufumaneka kwe-bioavailability emzimbeni.
Ubume bekhemikhali:I-folic acid yesiNtu luhlobo lokwenziwa lwefolate ekufuneka lungene kumanyathelo amaninzi okuguqula emzimbeni ngaphambi kokuba isetyenziswe.Ngakolunye uhlangothi, isizukulwana sesine se-folic acid, eyaziwa ngokuba yi-5-MTHF okanye i-Methyltetrahydrofolate, yindlela esebenzayo, ekhoyo ye-folate engadingi ukuguqulwa.
Ukufumaneka kwezinto eziphilayo:I-asidi ye-folic yesiko kufuneka iguqulelwe kwimo esebenzayo, i-5-MTHF, ngokuphendula kwe-enzymatic emzimbeni.Le nkqubo yokuguqula iyahluka phakathi kwabantu kwaye inokuphenjelelwa kukwahluka kofuzo okanye ezinye izinto.Ngokwahlukileyo, i-5-MTHF sele ikwimo yayo esebenzayo, eyenza ukuba ifumaneke ngokulula ekuthathweni kweselula kunye nokusetyenziswa.
Ukufunxa kunye nokusetyenziswa:Ukuxutywa kwe-folic acid yendabuko kwenzeka emathunjini amancinci, apho kufuneka aguqulwe kwifom esebenzayo nge-enzyme dihydrofolate reductase (DHFR).Nangona kunjalo, le nkqubo yokuguqulwa ayisebenzi kakhulu kwabanye abantu, okukhokelela ekunciphiseni ukufumaneka kwe-bioavailability.I-5-MTHF, ibe yifomu esebenzayo, ifunxeka ngokulula kwaye isetyenziswe ngumzimba, idlula inkqubo yokuguqula.Oku kuyenza ibe yindlela ekhethwayo kubantu abaneenguqu zofuzo okanye iimeko ezichaphazela i-folate metabolism.
Ukufaneleka kwabantu abathile:Ngenxa yomahluko wokufunxa kunye nokusetyenziswa, i-5-MTHF ithathwa njengento efanelekileyo kakhulu kubantu abaneenguqu ezithile zofuzo, ezifana nokuguqulwa kofuzo lwe-MTHFR, enokuphazamisa ukuguqulwa kwe-folic acid kwimo esebenzayo.Kwaba bantu, ukusebenzisa i-5-MTHF ngokuthe ngqo kunokuqinisekisa amanqanaba afanelekileyo e-folate emzimbeni kunye nokuxhasa imisebenzi eyahlukeneyo yebhayoloji.
Ukongeza:I-folic acid yesiNtu iqhele ukufunyanwa kwizongezelelo, ukutya okuqinisiweyo, kunye nokutya okucutshungulwayo, njengoko kuzinzile kwaye kungabizi kakhulu ukuvelisa.Nangona kunjalo, kukho ukufumaneka okukhulayo kwe-5-MTHF yezongezelelo ezibonelela ngefomu esebenzayo ngokuthe ngqo, enokuba luncedo kubantu abanobunzima bokuguqula i-folic acid.
Iziphumo ebezingalindelekanga zesizukulwana seSine se-folic acid (5-MTHF) zinqabile kwaye zithambile, kodwa kubalulekile ukuba uqaphele ukusabela okunokwenzeka:
Iintshukumo zokwalana:Njengaso nasiphi na isongezelelo okanye iyeza, ukuchasana nokwaliwa kuyenzeka.Iimpawu zisenokuquka irhashalala, ukurhawuzelelwa, ukudumba, ukuba nesiyezi, okanye ubunzima bokuphefumla.Ukuba ufumana nayiphi na kwezi mpawu, funa unyango ngokukhawuleza.
Imiba yokwetyisa:Abanye abantu banokuba neengxaki zesisu, ezifana nesicaphucaphu, ukuqunjelwa, igesi, okanye urhudo.Ezi zimpawu zidla ngokuba zezokwexeshana kwaye ziyancipha njengoko umzimba ulungelelanisa isongezelelo.
Ukunxibelelana namayeza:I-5-MTHF inokunxibelelana namayeza athile, kubandakanywa amayeza asetyenziselwa unyango lomhlaza, i-anticonvulsants, i-methotrexate, kunye ne-antibiotics ethile.Kubalulekile ukuthetha nomboneleli wakho wezempilo ukuba ngaba uthatha nawaphi na amayeza ukuqinisekisa ukuba akukho nxibelelwano lunokwenzeka.
Ukugqithisa okanye ukugqithiswa kwamanqanaba e-folate:Ngelixa kunqabile, ukutya kakhulu kwe-folate (kubandakanya i-5-MTHF) kunokukhokelela kumanqanaba aphezulu egazi le-folate.Oku kunokufihla iimpawu zokunqongophala kwe-vitamin B12 kwaye kuchaphazele ukuxilongwa kunye nonyango lweemeko ezithile.Kubalulekile ukulandela idosi ecetyiswayo kwaye udibane nengcali yezempilo ukuze ufumane isikhokelo.
Olunye uqwalaselo:Abasetyhini abakhulelweyo okanye abo baceba ukukhulelwa kufuneka bathethe nomboneleli wabo wezempilo ngaphambi kokuba bathathe iidosi eziphezulu ze-5-MTHF, njengoko ukuthatha i-folate ngokugqithiseleyo kunokufihla iimpawu zokunqongophala kwe-vitamin B12, ebalulekileyo kuphuhliso lwe-neural tube kwi-fetus.
Njengaso nasiphi na isongezelelo sokutya okanye amayeza, kuyafuneka ukuba uxoxe ngokusetyenziswa kwe-folic acid yesizukulwana seSine (5-MTHF) kunye nomboneleli wezempilo, ngakumbi ukuba unayo naziphi na iimeko zempilo eziphantsi okanye uthatha amanye amayeza.Banokubonelela ngeengcebiso ezizimeleyo ngokusekelwe kwiimfuno zakho ezithile kwaye bancede ukubeka iliso kuzo naziphi na iziphumo ebezingalindelekanga.
Isizukulwana sesine se-folic acid, ekwabizwa ngokuba yi-5-methyltetrahydrofolate (5-MTHF), luhlobo lwebhayoloji olusebenzayo lwe-folate olufunxwa lula kwaye lusetyenziswe ngumzimba xa kuthelekiswa nokongezwa kwe-folic acid yesiko.Nazi ezinye izifundo zenzululwazi ezixhasa ukusebenza kwayo:
Ukonyuka kokufumaneka kwe-bioavailability:I-5-MTHF ibonakaliswe ukuba ine-bioavailability enkulu kune-folic acid.Uphononongo olupapashwe kwi-American Journal of Clinical Nutrition luthelekisa i-bioavailability ye-folic acid kunye ne-5-MTHF kubasetyhini abanempilo.Ifumanise ukuba i-5-MTHF yafunxwa ngokukhawuleza kwaye yakhokelela kumanqanaba aphezulu e-folate kwiiseli ezibomvu zegazi.
Isimo se-folate esiphuculweyo:Izifundo ezininzi zibonise ukuba ukuxhaswa nge-5-MTHF kunokunyusa ngokufanelekileyo amanqanaba e-folate yegazi.Kulingo olulawulwa ngokungahleliwe olupapashwe kwiJenali yeSondlo, abaphandi bathelekisa iziphumo ze-5-MTHF kunye ne-folic acid supplementation kwisimo se-folate kubasetyhini abasempilweni.Baye bafumanisa ukuba i-5-MTHF yayisebenza ngakumbi ekunyuseni amanqanaba e-folate yeeseli ebomvu kune-folic acid.
Ukomelezwa kwe-folic acid metabolism:I-5-MTHF ibonakaliswe ukudlula amanyathelo e-enzymatic afunekayo ukuze kusebenze i-folic acid kunye nokuthatha inxaxheba ngokuthe ngqo kwi-cell folic acid metabolism.Uphononongo olupapashwe kwiJournal of Nutrition and Metabolism lubonise ukuba ukuxhaswa kwe-5-MTHF kuphuculwe i-intracellular folate metabolism kubantu abaneenguqu zofuzo kwii-enzymes ezibandakanyekayo ekusebenzeni kwe-folic acid.
Amanqanaba ancitshisiweyo e-homocysteine:Amanqanaba aphezulu e-homocysteine, i-amino acid egazini, adibaniswa nomngcipheko wokwanda kwezifo zentliziyo.Izifundo zibonise ukuba ukuxhaswa kwe-5-MTHF kunokunciphisa ngokufanelekileyo amanqanaba e-homocysteine.Uhlalutyo lwe-meta olupapashwe kwi-Journal ye-American College of Nutrition luhlalutye izilingo ezilawulwa ngokungahleliwe ze-29 kwaye zagqiba ukuba ukuxhaswa kwe-5-MTHF kwakusebenza ngakumbi kune-folic acid ekunciphiseni amanqanaba e-homocysteine.
Kubalulekile ukuba uqaphele ukuba iimpendulo zomntu ngamnye kwi-supplementation zinokwahluka, kwaye ukusebenza kwe-5-MTHF kunokuxhomekeka kwizinto ezifana nokwahluka kofuzo kwi-folate metabolism enzymes kunye nokutya ngokubanzi kokutya.Kuhlala kucetyiswa ukuba udibane nomboneleli wezempilo ukuze ufumane iingcebiso ezizezakho malunga nezongezelelo kunye nokuxoxa ngazo naziphi na iinkxalabo zempilo okanye iimeko ezithile.
