Ubonelelo lweFektri olucocekileyo lwe-β-Nicotinamide adenine dinucleotide (NAD)
I-β-Nicotinamide adenine dinucleotide (NAD) yi-coenzyme efumaneka kuzo zonke iiseli eziphilayo, idlala indima ebalulekileyo kwiinkqubo ezahlukeneyo ze-metabolic. Ibalulekile ekuvelisweni kwamandla, ukulungiswa kwe-DNA, kunye nokubonisana kweeseli. I-NAD ikhona ngeendlela ezimbini: i-NAD+ kunye ne-NADH, ezibandakanyeka kwiimpendulo ze-redox, zidlulisela ii-electron ngexesha leendlela ze-metabolic. I-NAD ibalulekile ekugcineni umsebenzi weseli kunye nempilo iyonke, kwaye amanqanaba ayo anokuchaphazela iinkqubo ezahlukeneyo ze-physiological. Isetyenziswa kakhulu kumayeza, i-biotechnology, kunye namashishini okutya, kunye nokuveliswa kwezongezo kunye nokutya okusebenzayo okujolise kwi-metabolism yamandla kunye nempilo yeseli. Kwindawo yefektri, i-NAD inokuveliswa ngokubiliswa, kusetyenziswa ii-microorganisms ukuguqula ii-precursor molecules zibe yi-NAD. Inkqubo yemveliso ibandakanya ulawulo olucokisekileyo lweemeko zokubiliswa ukuze kuphuculwe ukuguqulwa kwee-precursors zibe yi-NAD.
| Into | Ixabiso |
| Inombolo ye-CAS | 53-84-9 |
| Amanye Amagama | i-beta-Nicotinamide adenine dinucleotide |
| MF | C21H27N7O14P2 |
| Inombolo ye-EINECS | 200-184-4 |
| Indawo yemvelaphi | iTshayina |
| Uhlobo | IziPhakathi zeAgrochemical, IziPhakathi zeDyestuff, IziPhakathi zeFlavor & Fragrance, IziPhakathi zeSyntheses Material |
| Ubunyulu | 99% |
| Isicelo | Izinto eziPhakathi zeSinto |
| Inkangeleko | Umgubo omhlophe |
| Igama | i-beta-Nicotinamide adenine dinucleotide |
| MW | 663.43 |
| MF | C21H27N7O14P2 |
| Ifomu | Iqinile |
| Inkangeleko | Umgubo omhlophe |
| I-MOQ | 1kg |
| Iisampulu | Iyafumaneka |
| Beka ubomi kwishelufa | iminyaka eyi-2 |
Ubunyulu obuphezulu:I-NAD yethu iveliswa kusetyenziswa iinkqubo zokuvelisa eziphambili ukuqinisekisa ubunyulu obuphezulu, ihlangabezana nemigangatho engqongqo yomgangatho efunekayo kwizicelo zamayeza, i-biotechnology, kunye nokutya.
Umgangatho Ohlala Uhleli:Sigcina amanyathelo angqongqo okulawula umgangatho kuyo yonke inkqubo yemveliso ukuqinisekisa ukuba iimveliso zethu ze-NAD zihlala zihlangabezana neemfuno ezifunekayo kunye nemigangatho yokusebenza.
Izicelo Ezininzi:I-NAD yethu ingasetyenziswa kwiintlobo ngeentlobo zezicelo, kubandakanya amayeza, izongezo zokutya, ukutya okusebenzayo, kunye neenkqubo ze-biotechnology, ngenxa yendima yayo ebalulekileyo kwimetabolism yeseli kunye nemveliso yamandla.
Ukuthobela iMithetho:Iimveliso zethu ze-NAD zithobela imigangatho yemithetho yamazwe ngamazwe, ziqinisekisa ukuthotyelwa kwemigaqo nemigaqo efanelekileyo yokhuseleko nomgangatho.
Ubonelelo oluthembekileyo:Sinamandla okuvelisa kunye nezakhono zokulungiselela ukubonelela ngokubonelela okuthembekileyo nokungaguquguqukiyo kwe-NAD ukuhlangabezana neemfuno zabathengi bethu.
Uxhaso lobuchwepheshe:Iqela lethu leengcali linokubonelela ngenkxaso yobugcisa kunye nesikhokelo ekusebenziseni i-NAD kwizicelo ezahlukeneyo, ukuqinisekisa ukuba abathengi bethu banokusebenzisa kakhulu iingenelo zeemveliso zethu.
Lilonke, iimveliso zethu ze-NAD zibonakaliswa bubunyulu bazo obuphezulu, umgangatho wazo ohambelanayo, ukuguquguquka kwazo, ukuthobela imithetho, ukubonelela okuthembekileyo, kunye nenkxaso yobugcisa epheleleyo, nto leyo eyenza ukuba zilungele ukusetyenziswa kwemizi-mveliso nezorhwebo.
I-β-Nicotinamide adenine dinucleotide (NAD) ecocekileyo inika imisebenzi eyahlukeneyo kunye neenzuzo zempilo ezinokubakho, kubandakanya:
Imveliso yamandla:
I-NAD idlala indima ebalulekileyo ekuvelisweni kwe-adenosine triphosphate (ATP), imali yamandla ephambili yeseli. Ngokuthatha inxaxheba kwiimpendulo ze-redox, i-NAD inceda ekudlulisweni kwee-electron kwinkqubo ye-oxidative phosphorylation, ebalulekileyo ekuveliseni i-ATP kwi-mitochondria.
Ukuguqulwa kweSeli:
I-NAD ibandakanyeka kwiindlela ezahlukeneyo ze-metabolic, kubandakanya i-glycolysis, umjikelo we-tricarboxylic acid (TCA), kunye ne-oxidation ye-fatty acid. Ezi nkqubo zibalulekile ekuqhekekeni nasekusetyenzisweni kwezondlo kwimveliso yamandla kunye nokusebenza kweeseli.
Ukulungiswa kwe-DNA:
I-NAD sisithako esidibeneyo see-enzymes ezibandakanyeka kwiinkqubo zokulungisa i-DNA, ezifana nee-poly(ADP-ribose) polymerases (PARPs) kunye nee-sirtuins. Ezi enzymes zidlala indima ebalulekileyo ekugcineni uzinzo lwe-genomic kunye nokulungisa umonakalo we-DNA obangelwa ziingxaki ezahlukeneyo.
Umqondiso weSeli:
I-NAD isebenza njengesiseko se-sirtuins, udidi lweeproteni ezibandakanyekayo ekulawuleni iinkqubo zeseli ezifana nokubonakaliswa kwezakhi zofuzo, i-apoptosis, kunye nokuphendula koxinzelelo. Ii-Sirtuins zibandakanyeka kubomi obude kwaye zidibene neenzuzo zempilo ezinokubakho.
Iingenelo ezinokubakho kwimpilo:
Uphando lubonisa ukuba ukongezwa okanye ukuguqulwa kwamanqanaba e-NAD e-NAD kunokuba neengenelo zempilo, kubandakanya ukuxhasa ukusebenza kwe-mitochondrial, ukukhuthaza ukwaluphala okunempilo, kunye neemeko ezinokubangela impembelelo enxulumene nokungasebenzi kakuhle kwe-metabolic kunye noxinzelelo lweseli.
I-β-Nicotinamide adenine dinucleotide (NAD) ecocekileyo ineendlela ezahlukeneyo zokusetyenziswa kumashishini ahlukeneyo ngenxa yendima yayo ebalulekileyo kwimetabolism yeseli kunye nemveliso yamandla. Ezinye zeendlela eziphambili zokusetyenziswa kwe-NAD ecocekileyo ziquka:
Ishishini leMithi:
I-NAD isetyenziswa njengenxalenye ebalulekileyo kwimixube yamayeza, ingakumbi kumayeza ajolise kwiingxaki zemetabolism, ukungasebenzi kakuhle kwe-mitochondrial, kunye neemeko ezinxulumene nobudala. Ikwasetyenziswa kuphando nophuhliso lweendlela zonyango ezinokubakho.
Izongezo zokutya:
I-NAD ifakwe kwizongezo zokutya ezijolise ekuxhaseni impilo yeseli, imetabolism yamandla, kunye nempilo-ntle iyonke. Ezi zongezo zithengiswa ngenxa yamandla azo okukhuthaza ukwaluphala okunempilo kunye nokusebenza kwemetabolism.
Ukutya okuSebenzayo kunye neziSelo:
I-NAD isetyenziswa ekuphuhlisweni kokutya okusebenzayo kunye neziselo ezenzelwe ukuxhasa ukuveliswa kwamandla, impilo yeseli, kunye nokulinganisela kwemetabolism. Ezi mveliso zinokujolisa kubathengi abafuna iindlela zendalo zokuphucula impilo yabo iyonke kunye namandla abo.
I-Biotechnology:
I-NAD isetyenziswa kwiinkqubo ezahlukeneyo ze-biotechnology, kubandakanya inkcubeko yeseli, ukubila, kunye nobunjineli be-enzyme. Isebenza njenge-cofactor ebalulekileyo kwiimpendulo ezininzi ze-enzyme kunye neendlela ze-metabolic, nto leyo eyenza ukuba ibe luncedo kwi-bioprocessing kunye ne-biomanufacturing.
Uphando nophuhliso:
I-NAD isetyenziswa njengesixhobo sophando kwiilebhu zemfundo nezoshishino ukufunda imetabolism yeeseli, ukuveliswa kwamandla, kunye neenzuzo zempilo ezinokubakho ezinxulumene nokuguqulwa kwe-NAD. Ikwangumxholo wophando lwesayensi ngemiphumo yayo ekwaluphaleni, kwizifo zemetabolism, nakwiimeko ze-neurodegenerative.
Izinto zokuhombisa:
I-NAD ifakwe kwiimveliso zokhathalelo lolusu kunye nezobuhle ngenxa yamandla ayo okuxhasa impilo kunye namandla eeseli. Ithengiswa njengesithako esineempawu zokulwa nokwaluphala kunye nokuvuselela ulusu.
I-Extract yethu esekelwe kwiZityalo yenziwe kusetyenziswa amanyathelo olawulo lomgangatho angqongqo kwaye ilandela imigangatho ephezulu yeenkqubo zemveliso. Sibeka phambili ukhuseleko kunye nomgangatho wemveliso yethu, siqinisekisa ukuba iyahlangabezana neemfuno zomthetho kunye neziqinisekiso zoshishino. Oku kuzibophelela kumgangatho kujolise ekusekeni ukuthembana kunye nokuzithemba ekuthembekeni kwemveliso yethu. Inkqubo yemveliso ngokubanzi yile ilandelayo:
Indawo yokugcina: Gcina kwindawo epholileyo, eyomileyo, necocekileyo, Khusela ukufuma kunye nokukhanya okuthe ngqo.
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