I-Lycorine Hydrochloride
I-Lycorine hydrochloride ngumgubo ophuma kumhlophe ukuya kumhlophe ophuma kwi-alkaloid lycorine, efumaneka kwizityalo zeLycoris radiata (L'Her.), kwaye yeyosapho lwe-Amaryllidaceae. I-Lycorine hydrochloride ineempembelelo ezahlukeneyo ze-pharmacological, ezibandakanya i-anti-tumor, i-anti-cancer, i-anti-HCV, i-anti-inflammatory, anti-bacterial, anti-virus, i-anti-angiogenesis, kunye ne-anti-malaria properties. Iyanyibilika emanzini, i-DMSO, kunye ne-ethanol. Ubume bayo beekhemikhali bubonakaliswe ngesakhelo se-steroidal esiyinkimbinkimbi kunye nencasa ekrakra kunye namaqela amaninzi asebenzayo, kuquka i-hydroxyl kunye namaqela e-amino, afaka isandla kwimisebenzi yayo yezinto eziphilayo.
| Igama lemveliso | I-Lycorine hydrochloride CAS: 2188-68-3 | ||
| Umthombo wezityalo | Lycoris | ||
| Imeko yokugcina | Gcina ngesitywina kwiqondo lokushisa | Umhla wengxelo | 2024.08.24 |
| Into | Umgangatho | Isiphumo |
| Ubunyulu(HPLC） | I-Lycorine hydrochloride≥98% | 99.7% |
| Imbonakalo | Umgubo omhlophe ngaphandle | Iyahambelana |
| Umlinganiswa womzimbaics | ||
| Ubungakanani besuntswana | NLT100% 80Umnatha | Iyahambelana |
| Ilahleko ekomisweni | ≤1.0% | 1.8% |
| Inzima intsimbi | ||
| Iintsimbi zizonke | ≤10.0ppm | Iyahambelana |
| Inkokeli | ≤2.0ppm | Iyahambelana |
| IMercury | ≤1.0ppm | Iyahambelana |
| I-Cadmium | ≤0.5ppm | Iyahambelana |
| I-Microorganism | ||
| Lilonke inani lebhaktheriya | ≤1000cfu/g | Iyahambelana |
| Igwele | ≤100cfu/g | Iyahambelana |
| Escherichia coli | Ayiqukwanga | Ayifunyaniswanga |
| Salmonella | Ayiqukwanga | Ayifunyaniswanga |
| Staphylococcus | Ayiqukwanga | Ayifunyaniswanga |
| Izigqibo | Ufanelekile | |
Iimbonakalo:
(1) Ubunyulu obuPhezulu:Imveliso yethu icutshungulwa ngokucokisekileyo ukuqinisekisa umgangatho ophezulu wokucoceka, obalulekileyo ekusebenzeni kwayo kunye nokhuseleko kwizicelo ezahlukeneyo.
(2) Iinkcazelo ngeempawu zomhlaza:Ibonise iziphumo ezibalulekileyo ze-anticancer ngokuchasene neentlobo ezahlukeneyo zomhlaza, zombini kwi-vitro kunye ne-vivo, ngokusebenzisa iindlela ezifana nokunyanzelwa ukubanjwa komjikelo weseli, ukubangela i-apoptosis, kunye nokuthintela i-angiogenesis.
(3) Isenzo esiSetyenziselwe izinto ezininzi:I-Lycorine hydrochloride ikholelwa ukuba isebenzisana neethagethi ezininzi zeemolekyuli, ibonelela ngokusebenza okubanzi ngokuchasene neeseli zomhlaza.
(4) Ubutyhefu obuphantsi:Ibonisa ubuthi obuphantsi kwiiseli eziqhelekileyo, eyona nto ibalulekileyo ekusetyenzisweni kwayo njenge-agent yonyango.
(5) Iprofayili ye-Pharmacokinetic:Imveliso ifundwe kwi-pharmacokinetics yayo, ibonisa ukuxutywa ngokukhawuleza kunye nokupheliswa ngokukhawuleza kwi-plasma, okubalulekileyo kwi-dosing kunye nokucwangciswa kwonyango.
(6) Iziphumo zeSynergistic:I-Lycorine hydrochloride ibonise iziphumo eziphuculweyo xa isetyenziswe ngokudibeneyo namanye amachiza, anokuba luncedo ekoyiseni ukuxhathisa amachiza kunye nokuphucula iziphumo zonyango.
(7) UPhando-luxhaswe:Imveliso ixhaswa ngophando olubanzi, inika isiseko esiluqilima sokusetyenziswa kwayo ekuphuhliseni amayeza kunye nezicelo zeklinikhi.
(8) UQinisekiso loMgangatho:Amanyathelo okulawula umgangatho ongqongqo akhona kuyo yonke inkqubo yokuvelisa ukuqinisekisa ukuhambelana nokuthembeka kwemveliso.
(9) Izicelo eziNyezo:Ifanelekile ukusetyenziswa kuphando kunye nophuhliso lwezicelo zamachiza, kubandakanywa ukufunyanwa kweziyobisi kunye nophuhliso lonyango lomhlaza.
(10) Ukuthobela:Yenziwe ngokulandela imigangatho ye-GMP ukuqinisekisa ukhuseleko kunye nokusebenza kakuhle kwemveliso.
(1) Ishishini loShishino:I-Lycorine hydrochloride isetyenziselwa ukuphuhliswa kwamachiza e-antiviral kunye ne-anticancer.
(2) Ishishini leBiotechnology:Isetyenziswa kuphando kunye nophuhliso lweearhente ezintsha zonyango kunye nokwakhiwa kwamachiza.
(3) Uphando lwemveliso yendalo:I-Lycorine hydrochloride ifundelwa iinzuzo zayo zempilo kunye neempawu zonyango.
(4) Ishishini lemichiza:Ingasetyenziswa njengekhemikhali ephakathi ekudityanisweni kwezinye iikhompawundi.
(5) Ishishini lezolimo:I-Lycorine hydrochloride iphandwe ngamandla ayo njengeyeza lendalo lezinambuzane kunye nokulawula ukukhula kwezityalo.
Inkqubo yokukhutshwa kwe-lycorine hydrochloride idla ngokubandakanya la manyathelo alandelayo okuqinisekisa ukucoceka kwe-solvent kunye nokuphucula izinga lokubuyisela:
(1) Ukhetho lwemathiriyeli ekrwada kunye nonyango lwangaphambili:Khetha izixhobo ezifanelekileyo zesityalo se-Amaryllidaceae, njengeebhalbhu ze-Amaryllis, kwaye uzihlambe, zomise kwaye uzityumze ukuqinisekisa ukucoceka kwezinto eziluhlaza kwaye ubeke isiseko sokutsalwa okulandelayo.
(2)Unyango lwangaphambili lwe-enzyme edibeneyo:Sebenzisa ii-enzymes ezintsonkothileyo (ezifana ne-cellulase kunye ne-pectinase) ukuze uphathe kwangaphambili izinto ezikrwada ezityumkileyo ukubola iindonga zeeseli zezityalo kunye nokuphucula ukusebenza kakuhle kokutsalwa okulandelayo.
(3)Nciphisa i-hydrochloric acid leaching:Xuba imathiriyeli ekrwada esetyenzisiweyo kunye nesisombululo se-hydrochloric acid exutywe ukukhupha i-lycorine. Ukusetyenziswa kwe-hydrochloric acid kunceda ukwandisa ukunyibilika kwe-lycorine, ngaloo ndlela kuphuculwe ukusebenza kakuhle kokutsalwa.
(4)Utsalo oluncediswa yi-Ultrasonic:Ukusetyenziswa kweteknoloji ye-ultrasonic-assisted extraction inokukhawuleza inkqubo yokuchithwa kwe-lycorine kwi-solvent kunye nokuphucula ukusebenza kakuhle kunye nokucoceka.
(5)Ukukhutshwa kweChloroform:Ukukhutshwa kwenziwa nge-solvents ye-organic efana ne-chloroform, kwaye i-lycorine idluliselwa kwisigaba samanzi ukuya kwinqanaba le-organic ukuze ihlambuluke ngakumbi i-compound ekujoliswe kuyo.
(6)Ukubuyisela ukunyibilika:Emva kwenkqubo yokutsalwa, i-solvent ibuyiswa ngokunyuka kwe-evaporation okanye i-distillation ukunciphisa ukusetyenziswa kwe-solvent kunye nokuphucula uqoqosho.
(7)Ukucocwa nokomiswa:Ngokusebenzisa amanyathelo afanelekileyo okucoca kunye nokomisa, i-lycorine hydrochloride powder ecocekileyo ifunyenwe.
Kuyo yonke inkqubo yokukhutshwa, ukulawula ukukhethwa kwe-solvent, iimeko zokukhutshwa (ezifana nexabiso le-pH, ukushisa, kunye nexesha), kunye namanyathelo okuhlanjululwa okulandelayo kuyisitshixo sokuqinisekisa ukucoceka kwe-solvent kunye nokuphucula izinga lokubuyisela. Ukusetyenziswa kwezixhobo zanamhlanje zokutsalwa kunye nokucoca, ezifana ne-ultrasonic extractors kunye ne-high-performance liquid chromatography (HPLC) iinkqubo, zikwanceda ukuphucula ukusebenza kakuhle kwe-extraction kunye nomgangatho wemveliso.
Ugcino: Gcina kwindawo epholileyo, eyomileyo, necocekileyo, Khusela kubumanzi nasekukhanyeni okuthe ngqo.
Iphakheji eninzi: 25kg / idrum.
Ixesha lokukhokela: Iintsuku ezi-7 emva komyalelo wakho.
Ubomi beShelf: iminyaka emi-2.
Phawula: Iinkcukacha ezilungiselelweyo nazo zinokufezekiswa.
Express
Ngaphantsi kwe-100kg, iintsuku ezi-3-5
Umnyango ukuya emnyango inkonzo lula ukuthatha iimpahla
Ngaselwandle
Ngaphezulu kwe-300kg, malunga neentsuku ezingama-30
Izibuko ukuya kwinkonzo yezibuko i-broker yobuchwephesha efunekayo
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100kg-1000kg, 5-7Days
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I-Bioway Organic ifumene i-USDA kunye ne-EU organic, i-BRC, i-ISO, i-HALAL, i-KOSHER, kunye nezatifikethi ze-HACCP.
I-Lycorine yi-alkaloid eyenzeka ngokwemvelo enokufumaneka kwizityalo ezininzi, ngakumbi phakathi kosapho lwe-Amaryllidaceae. Nazi ezinye izityalo ezaziwa ngokuba zine-lycorine:
I-Lycoris radiata(ekwaziwa njenge-red spider lily okanye i-manjushage) liyeza lesintu lamayeza laseTshayina eliqulathe i-lycorine.
Leucojum aestivum(Ikhephu lekhephu lasehlotyeni), likwabizwa ngokuba liqukethe i-lycorine.
Ungernia sewertzowiisesinye isityalo esiphuma kusapho lwe Amaryllidaceae ekuye kwaxelwa ukuba sine lycorine.
I-Hippeastrum hybrid (inyibiba yePasika)kunye nezinye izityalo ezinxulumene ne-Amaryllidaceae ziyaziwa njengemithombo ye-lycorine.
Ezi zityalo zisasazwe ngokubanzi kwiindawo ezishushu kunye neendawo ezitshisayo kwihlabathi jikelele kwaye zinembali ende yokusetyenziswa kumayeza esintu. Ubukho be-lycorine kwezi zityalo kuye kwaba ngumxholo wophando ngenxa yeempawu zayo ze-pharmacological, kubandakanywa nemiphumo ebalulekileyo ye-anticancer njengoko kubonisiwe kwizifundo ezahlukeneyo.
I-Lycorine yi-alkaloid yendalo enoluhlu olubanzi lweempembelelo ze-pharmacological, kubandakanywa nokusetyenziswa kwayo kunyango lomhlaza. Ngelixa ibonise iziphumo ezithembisayo kwizifundo ezahlukeneyo, kukho iziphumo ebezingalindelekanga ezixeliweyo kunye neengqwalasela ezinxulumene nokusetyenziswa kwayo:
Ubuthi obuphantsi: I-Lycorine kunye netyuwa yayo ye-hydrochloride ngokubanzi ibonisa ubutyhefu obuphantsi, oluphawu oluthandekayo kwizicelo zeklinikhi. Kubonakaliswe ukuba ineempembelelo ezimbi ezincinci kwiiseli zomntu eziqhelekileyo kunye neempuku ezinempilo, ephakamisa inqanaba elithile lokukhetha iiseli zomhlaza ngaphezu kwezicubu eziqhelekileyo.
Iimpembelelo ze-Emetic eziThutyanayo: Isicaphucaphu kunye nokugabha okwethutyana kuye kwabonwa kulandela inaliti engaphantsi kwesikhumba okanye nge-intravenous ye-lycorine hydrochloride, ngokuqhelekileyo iyancipha kwiiyure ze-2.5 ngaphandle kokuchaphazela ukhuseleko lwe-biochemical okanye lwe-hematological.
Akukho kuLungelelwaniso lweeMoto eziphazamisekileyo: Uphononongo lubonise ukuba i-serial doses ye-lycorine ayichaphazeli ukulungelelaniswa kwemoto kwiigundane, njengoko ihlolwe nguvavanyo lwe-rotarod, ebonisa ukuba ayikhokelela kwimiphumo yecala ye-nervous system (CNS) ehambelana nokulawula imoto.
Impembelelo kwi-Spontaneous Locomotor Activity: Kwi-dose ye-30 mg / kg, i-lycorine iye yabonwa ukuba iphazamise umsebenzi we-locomotor ngokuzenzekelayo kwiigundane, njengoko kuboniswe ngokunciphisa ukuziphatha kokukhulisa kunye nokunyuka kokungahambi.
Ukuziphatha Jikelele kunye nokuphila kakuhle: I-dose ye-10 mg / kg ye-lycorine ayizange iphazamise ukuziphatha okuqhelekileyo kunye nentlalontle yeegundane, ebonisa ukuba le nto ingaba yi-dose ephezulu kwiimvavanyo ezisebenzayo zonyango kwixesha elizayo.
Akukho ziphumo ezibi kakhulu kuMzimba woMzimba okanye kwiSimo seMpilo: Ulawulo lwe-lycorine kunye ne-lycorine hydrochloride aluzange lubangele imiphumo ebonakalayo kubunzima bomzimba okanye imeko yezempilo jikelele kwiimodeli zemouse ezithwele i-tumor.
Kubalulekile ukuqaphela ukuba ngelixa i-lycorine ibonise amandla kuphando lwangaphambili, uvavanyo lwexesha elide lwetyhefu lusanqongophala. Uphando olongezelelweyo luyafuneka ukuze uqonde ngokupheleleyo iprofayili yokhuseleko, ngakumbi ukusetyenziswa kwexesha elide kunye nakwiimeko zonyango. Imiphumo emibi kunye nokhuseleko lwe-lycorine lunokwahluka ngokuxhomekeka kwi-dosage, indlela yokulawula, kunye neempawu zesigulane ngasinye. Soloko ubonisana nengcali yezempilo phambi kokuba uqwalasele ukusetyenziswa kwaso nasiphi na isongezelelo esitsha okanye unyango.
