I-Lycorine Hydrochloride
I-Lycorine Hydrochloride i-white umgubo-mhlophe ikhupha i-alkaloid ye-alkaloid yeyscorine, efumaneka kwizityalo ze-lycoris radiata (i-yam.), Kwaye zezakwintsapho yaseAmcoridace. Lycorine hydrochloride has various potential pharmacological effects, including anti-tumor, anti-cancer, anti-HCV, anti-inflammatory, anti-bacterial, anti-virus, anti-angiogenesis, and anti-malaria properties. Inyibiliza emanzini, idroso ne-ethanol. Isakhiwo sayo semichiza siphawulwa yinkqubo ye-Steroidal entsonkothileyo kunye nengca ekrakra ngamaqela amaninzi, kubandakanya namaqela e-hydroxyl kunye namaqela, inegalelo kwimisebenzi yayo yebhayoloji.
| Igama lemveliso | I-Lycorine Hydrochloride Case: 2188-68-3 | ||
| Umthombo weSityalo | Lycoris | ||
| Imeko yokugcina | Gcina ngetywina kubushushu begumbi | Ingxelo yomhla | 2024.08.24 |
| Into | Umgangatho | Isiphumo |
| Ubunyulu(Hlc) | I-Lycorine Hydrochloride≥98% | I-99.7% |
| Imbonakalo | Ipowder emhlophe | Ivumelana |
| Itekisi yomzimbaics | ||
| Ubungakanani-ubungakanani | I-NLT100% 80Mesh | Ivumelana |
| Ilahleko yokomisa | ≤1.0% | I-1.8% |
| Inzima intsimbi | ||
| I-metals iyonke | ≤10.0ppm | Ivumelana |
| Khokelela | ≤2.0ppm | Ivumelana |
| I-mercury | ≤1.0ppm | Ivumelana |
| I-cadmium | ≤0.5PPM | Ivumelana |
| I-microorganism | ||
| Inani lilonke le-bacteria | ≤1000cfu / g | Ivumelana |
| Igwele | ≤100cfu / g | Ivumelana |
| I-Escherichia Coli | Ayifakwanga | Ayifunyenwanga |
| Isalmonella | Ayifakwanga | Ayifunyenwanga |
| I-staphylocococcus | Ayifakwanga | Ayifunyenwanga |
| Izigqibo | Bafanelekile | |
Iimbonakalo:
(1) Ucoceko oluphezulu:Imveliso yethu iyalungiswa ngokusesikweni ukuqinisekisa ukuba kwinqanaba eliphezulu lokucoceka, nto leyo ebalulekileyo ekusebenzeni nasekukhuseleni izicelo ezahlukeneyo.
(2) Iipropathi ze-anticialr:Ibonise iziphumo ezibalulekileyo ze-antiness kwindidi ezahlukeneyo zomhlaza, zombini e-vimpo kunye ne-Vivo, ngeendlela ezifana nokuphembelela ngomjikelo weseli, zibaleka i-Apoptosis, kunye nokuthintela i-Aupoogenesis.
(3) Intshukumo nganye:I-Lycorine Hydrochloride ikholelwe ukuba inxibelelane neethagethi ezininzi zemolekyuli, ukuhambisa ukusebenza ngempumelelo kwemali ebanzi ngokuchasene neeseli zomhlaza.
(4) Ityhefu esezantsi:Ibonisa ubuncwane obuphantsi kwiiseli eziqhelekileyo, eziyimfuneko ekusebenziseni okunokubakho njengearhente yonyango.
(5) Iprofayile ye-pharmacokinetic:Imveliso ifundwe i-pharmacokinetics yayo, ibonisa ukufunxa okukhawulezayo kunye nokupheliswa ngokukhawuleza kwiPlasma, ebaluleke kakhulu ekucwangcisweni kwesempini kunye nokucwangciswa konyango.
(6) IIMPENDULO ZEMISEBENZI:I-Lycorine Hydrochloride ibonakalise iziphumo eziphuculweyo xa isetyenziswa ngokudibeneyo kunye nezinye iziyobisi, ezinokuba yingenelo ekuchazeni iziyobisi kunye nokuphucula iziphumo zonyango.
(7) Uphando:Imveliso ixhaswa ngophando olubanzi, ukubonelela ngesiseko esomeleleyo sokusetyenziswa kwalo kuPhuhliso lwamayeza kunye nokuSebenza kwiKlinikhi.
(8) Ukuqinisekiswa komgangatho:Amanyathelo olawulo oluthile lomgangatho akhona kwinkqubo yemveliso ukuqinisekisa ukungqinelana kunye nokuthembeka kwemveliso.
(9) Izicelo eziguquguqukayo:Ilungele ukusetyenziswa kuphando kunye nophuhliso kwizicelo zamayeza, kubandakanya nokufunyanwa kweziyobisi kunye nomhlaza onyango.
(10) Ukuthobela:Yenza imigangatho ye-GPP ye-GP yokuqinisekisa ukhuseleko lwemveliso kunye nokusebenza kakuhle.
(1) Umzi mveliso wamachiza:I-Lycorine Hydrochloride isetyenziswa ekuphuhlisweni kwamayeza a-antiviral kunye namayeza okuvala.
(2) Imveliso ye-bitechnology:Isetyenziswa kuphando kunye nophuhliso lweearhente ezintsha zonyango kunye neendlela zeziyobisi.
(3) UPhando lweMveliso yeNdalo:I-Lycorine Hydrochloride ifundwa ngenxa yezibonelelo zempilo kunye neepropathi zonyango.
(4) Ishishini leekhemikhali:Ingasetyenziswa njengekhemikhali ephakathi kwi-synthes yeminye imichiza.
(5) Ishishini lezoLimo:I-Lycorine Hydrochloride ikhutshwe ngamandla ayo njengezibulalambo zendalo kunye nokukhula kwezityalo.
Inkqubo yokukhupha i-lycorine hydrochloride idla ngokusebenzisa la manyathelo aphambili okuqinisekisa ukucoceka kwesinyibilikisi kunye nokuphucula umgangatho wokubuyisela:
(1) Yilondolozwe kukhetho lwezinto eziphathekayo kunye nokwamkelwa:Khetha izinto ezifanelekileyo zeAmaryllidaceae Tainta izixhobo eziluhlaza, ezinjenge-Amirylis Bulbs, kwaye uhlamba, womile kwaye ubatyumze ukuqinisekisa ukucoceka kwezinto eziluhlaza kwaye ubeke isiseko sendawo yokukhupha.
(2)I-Enzyme Realyme:Sebenzisa i-enzymes entsonkothileyo (efana ne-selselase kunye ne-pecccccccccccccccccccccrinase) ukulungisa izinto ezingafunekiyo ukubola iindonga zeseli kunye nokuphucula ukusebenza ngokukuko.
(3)Dilute Hydrochloric aid:Hlanganisa izinto ezingafunekiyo ezichaziweyo nge-dilchrochloric acid acid yokufumana i-lycorine. Ukusetyenziswa kwe-hydrochloric acid kunceda ukwandisa ukunyibilisela i-lycorine, ngaloo ndlela kuphucule ukusebenza kakuhle.
(4)Ukukhutshwa kwe-UltrasonicUkusetyenziswa kwetekhnoloji yokukhupha i-Ultrasonic encedisayo kunokukhawulezisa inkqubo yokutshintsha kwe-lycorine kwi-solvent kunye nokuphucula ukusebenza kakuhle nokucoceka.
(5)I-chloroform yokukhuphela:Ukukhutshelwa kwenziwa kunye nezinyibilikisi zezinto eziphilayo ezinje nge-chloroform, kwaye i-LYCORIne idluliselwa kwinqanaba le-ACTEOCT kwisigaba sezinto eziphilayo ukuze sicoceke.
(6)Ukubuyiswa kwesilivere:Emva kwenkqubo yokukhupha, inyibilikisiwe ifunyenwe ngokuphuma okanye i-school ukunciphisa ukusetyenziswa nokusetyenziswa okusombululwayo kunye nokuphucula ezoqoqosho.
(7)Ukucocwa kunye nokomisa:Ngokucocwa ngokufanelekileyo kunye namanyathelo okomisa, i-Lydrocrine esulungekileyo ye-hydrochloside ifunyenwe.
Kuyo yonke inkqubo yokukhutshwa, ukulawula ukukhetha kweSolvent, iimeko zokukhupha (njengexabiso le-pH, amaqondo obushushu, kunye namanyathelo okucoca alandelayo sisitshixo sokuqinisekisa ukucoceka kunye nokuphucula umgangatho wokubuyisela kwimeko yesiqhelo. Ukusetyenziswa kwesixhobo sokucoca kunye nezixhobo zokucoca, ezinjenge-Ultradonic ye-Ultramonic kunye neenkqubo zokusebenza eziphezulu zeChromatography (i-HLCC), ikwanceda ekuphuculeni umgangatho wokuqinisekisa kunye nomgangatho wemveliso.
Ukugcinwa: Gcina kwindawo epholileyo, eyomileyo necocekileyo, ikhusele ekuthambekeni nasekukhanyiseni ngokuthe ngqo.
Iphakheji ye-Bulk: 25kg / idrum.
Ixesha le-Comhsho: kwiintsuku ezisi-7 emva kolungelelwano lwakho.
Ubomi beshelup: iminyaka emi-2.
I-IRGUCHE: Inkcazo ngokwesiko nayo inokufezekiswa.
Chaza
Ngaphantsi kwe-100kg, i-3-5 yantwana
Umnyango kwinkonzo yendlu kulula ukuthabatha iimpahla
Ngolwandle
Ngaphezulu kwe-300kg, malunga neentsuku ezingama-30
I-Port ukuya kwi-Port Point Conseker Bricker efunekayo
Ngomoya
I-100kg-1000kg, 5-7 days
Isikhululo senqwelomoya esiya kwisikhululo senqwelomoya senkonzo yeSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seNkonzo esiyifunayo
I-bioway ye-organic ifumene i-USDA kunye ne-EUORD, i-BRC, i-IS, Halal, iKosher, kunye neZatifikethi zeHaccp.
I-LYCORINE yindalo yendalo i-alkaloid yendalo enokufumaneka kwizityalo ezininzi, ngakumbi ngaphakathi kosapho lwaseAmryllidaceae. Nazi ezinye izityalo ezaziweyo ziqulathe i-lycorine:
I-lycoris radiata.
I-Leucojum Aestivum(Ihlobo lekhephu lekhephu), iyaziwa ukuba iqulethe i-LYCORIF.
Urgernia sewertzwiiiisesinye isityalo kwintsapho yaseAmmaryllidaceae exeliweyo ukuba iqulethe i-LYCORIF.
I-Hippeastrum hybrid (i-Istaily Lily)Kwaye ezinye izityalo ezinxulumene ne-Amaryllidaceae yimithombo ye-LYCORORIN.
Ezi zityalo zisasazwa ngokubanzi kwimimandla enamatye kunye ne-subropical kwihlabathi jikelele kwaye inembali ende yokusetyenziswa kumayeza emveli. Ubukho be-lycorine kwezi zityalo ibingumbandela wophando ngenxa yeepropathi zayo ezinokubakho ze-pharmacogical, kubandakanya neziphumo zayo ze-anticeyer njengoko kubonisiwe kwizifundo ezahlukeneyo.
I-Lycorine yi-alkaloid yendalo enoluhlu olubanzi lweZiphumo zePhematical, kubandakanya ukusetyenziswa kwayo kunyango lomhlaza. Ngelixa ibonisile iziphumo ezithembisayo kwizifundo ezahlukeneyo, kukho iziphumo ebezingalindelekanga kwaye ziqwalaselwa ngokusetyenziswa kwayo:
Ityhefu esezantsi: I-Lycorine kunye ne-hydrochloride ityuwa ngokubanzi ibonisa ubuqili obuthathaka, oluhlobo olufanelekileyo lwezicelo zeklinikhi. Ibonisiwe ukuba inefuthe elincinci leeseli eziqhelekileyo zabantu kunye neempuku ezinempilo, iphakamisa inqanaba elithile lokukhetha iiseli zomhlaza ngaphezulu kwezicubu eziqhelekileyo.
Iziphumo ze-Emeriting ze-Emetic: I-NEAMEA YASEKHAYA NOKUVUNYELWA KUTSHINTSHIWEYO EYENZA INDLELA YOKUZIPHATHA OKANYE I-LYCOROOOUON OKANYE YOKUGQIBELA I-LYCOROCHRONRIDROCHROCHONICEID, idla ngokhuseleko kwiiyure ezi-2,5 ngaphandle kokuchaphazela i-biochemical okanye ukhuseleko lwe-hematological.
AKUKHO BUNGOZI LOKWENZA IZIPHUMO: IZIFUNDO ZIYABONAKALISA I-SOPCORINS ye-LYCORIF ayichaphazeli ukulungelelaniswa kweempuku, njengoko kuvavanywa ukuba ayikhokeli kwi-nertieds yenkqubo ye-nervous enxulumene nolawulo lweemoto.
Impembelelo kwimisebenzi ye-spontaneous ye-lecomotor: kwidosi ye-30 mg / kg, i-LYCORIN iqatshelwe ukuba inciphise umsebenzi we-spontaneous ye-lecomoous ye-lecomoous ye-leComoot ye-Locaneous kwimpuku, njengoko kubonisiwe ekungasebenziyo.
Ukuziphatha kakuhle kunye nempilo-ntle: Idosi ye-10 mg / kg yaseLycorine ayizange inciphise indlela yokuziphatha kunye nentlalo-ntle yeempuku, iphakamisa ukuba oku kunokuba yidosi efanelekileyo yonyango.
Akukho ziphumo zimbi zibalulekileyo kubunzima bomzimba okanye ubume bezempilo: Ulawulo lweLycorine kunye ne-Lycorine Hydrochloride ayizange ibangele iziphumo ebezingabonakaliyo kubunzima bomzimba okanye i-cumor iyodwa kwimodeli yemouse ye-tumar.
Kubalulekile ukuba uqaphele ukuba ngelixa i-Lycorine ibonakalise amandla kuphando oluchanekileyo lophando, uvavanyo lwexabiso elide kakhulu lusasilela. Qiniseka ngakumbi uphando ukuze uqonde ngokupheleleyo iprofayile yokhuseleko, ngakumbi ukusetyenziswa kwexesha elide nakwiseto seklinikhi. Iziphumo ebezingalindelekanga kunye nokukhuseleka kweLycorine kungahluka ngokuxhomekeka kumthamo, indlela yolawulo, kunye neempawu zesigulana. Soloko unxibelelana nengcali yezempilo ngaphambi kokuba ucinge ngokusetyenziswa kwayo nayiphi na eyongezelelweyo okanye unyango.
