Vinca Rosea Extract Vincristine
IVinca Rosea Extract Vincristine ibhekisa kwikhompawundi yamayeza iVincristine, ethatyathwe kwisityalo seperiwinkle (Vinca rosea), ekwaziwa njengeCatharanthus roseus, amehlo aqaqambileyo, iCape periwinkle, isityalo samangcwaba, iMadagascar periwinkle, isicakakazi esidala, ipinki periwinkle, rose. I-periwinkle, luhlobo oluhlala luhlala lwesityalo esineentyatyambo kusapho lwe-Apocynaceae.
IVincristine yialkaloid yendalo kwaye isetyenziswa njengeyeza lechemotherapy ukunyanga iintlobo ezahlukeneyo zomhlaza, kubandakanya i-leukemia, i-lymphoma, kunye namathumba aqinileyo. Isebenza ngokuphazamisa ukukhula kweeseli zomhlaza.
| Izithako eziphambili ezisebenzayo ngesiTshayina | Igama lesiNgesi | Inombolo yeCAS. | Ubunzima beMolekyuli | Ifomula yeemolekyuli |
| 长春胺 | Vincamine | 1617-90-9 | 354.44 | I-C21H26N2O3 |
| 脱水长春碱 | I-Anhydrovinblastine | 38390-45-3 | 792.96 | I-C46H56N4O8 |
| 異長春花苷內酰胺 | I-Strictosamide | 23141-25-5 | 498.53 | I-C26H30N2O8 |
| 四氢鸭脚木碱 | Tetrahydroalstonine | 6474-90-4 | 352.43 | I-C21H24N2O3 |
| 酒石酸长春瑞滨 | IVinorelbine Tartrate | 125317-39-7 | 1079.12 | C45H54N4O8.2(C4H6O6);C |
| 长春瑞滨 | Vinorelbine | 71486-22-1 | 778.93 | I-C45H54N4O8 |
| 长春新碱 | Vincristine | 57-22-7 | 824.96 | I-C46H56N4O10 |
| 硫酸长春新碱 | IVincristine sulfate | 2068-78-2 | 923.04 | I-C46H58N4O14S |
| 硫酸长春质碱 | Catharanthine Sulfate | 70674-90-7 | 434.51 | I-C21H26N2O6S |
| 酒石酸长春质碱 | Catharanthine hemitartrate | 4168-17-6 | 486.51 | C21H24N2O2.C4H6O6 |
| 长春花碱 | Vinblastine | 865-21-4 | 810.99 | I-C46H58N4O9 |
| 长春质碱 | I-Catharanthini | 2468-21-5 | 336.43 | I-C21H24N2O2 |
| 文朵灵 | Vindoline | 2182-14-1 | 456.53 | I-C25H32N2O6 |
| 硫酸长春碱 | IVinblastine Sulfate | 143-67-9 | 909.05 | I-C46H60N4O13S |
| β-谷甾醇 | β-Sitosterol | 83-46-5 | 414.71 | C29H50O |
| 菜油甾醇 | Campesterol | 474-62-4 | 400.68 | C28H48O |
| 齐墩果酸 | Oleanolic acid | 508-02-1 | 456.7 | C30H48O3 |
| INGCACISO YEMVELISO | ||
| Igama lemveliso: | Vinca rosea ngqo | |
| Igama leBhotani: | I-Catharanthus roseus (L.) | |
| Inxalenye yesityalo | Intyatyambo | |
| Ilizwe lemveli: | eTshayina | |
| UKUHLALUTYA IZINTO | INGCACISO | INDLELA YOVAVANYO |
| Imbonakalo | Umgubo ococekileyo | I-Organoleptic |
| Umbala | Umgubo omdaka omdaka | Okubonakalayo |
| Ivumba kunye neNcasa | Uphawu | I-Organoleptic |
| Ukuchongwa | Iyafana nesampulu yeRS | HPTLC |
| Ukukhupha umlinganiselo | 4:1–20:1; Vincristine 98% min | |
| Uhlalutyo lweSieve | I-100% nge-80 mesh | USP39 <786> |
| Ilahleko ekomisweni | ≤ 5.0% | I-Eur.Ph.9.0 [2.5.12] |
| IAsh iyonke | ≤ 5.0% | I-Eur.Ph.9.0 [2.4.16] |
| Khokela (Pb) | ≤ 3.0 mg / kg | I-Eur.Ph.9.0<2.2.58>ICP-MS |
| IArsenic (Nje) | ≤ 1.0 mg / kg | I-Eur.Ph.9.0<2.2.58>ICP-MS |
| I-Cadmium(Cd) | ≤ 1.0 mg / kg | I-Eur.Ph.9.0<2.2.58>ICP-MS |
| IMercury(Hg) | ≤ 0.1 mg / kg -Reg.EC629/2008 | I-Eur.Ph.9.0<2.2.58>ICP-MS |
| Intsimbi enzima | ≤ 10.0 mg / kg | I-Eur.Ph.9.0<2.4.8> |
| Intsalela yezinyibilikisi | Ukungqinelana ne-Eur.ph. 9.0 <5,4> kunye ne-EC European Directive 2009/32 | I-Eur.Ph.9.0<2.4.24> |
| Iintsalela zezitshabalalisi | Conform Regulations(EC) No.396/2005kubandakanya izihlomelo kunye nohlaziyo olulandelelanayo Reg.2008/839/CE | Igesi Chromatography |
| Ibhaktheriya yeAerobic (TAMC) | ≤10000 cfu/g | USP39 <61> |
| Igwele/Ukungunda(TAMC) | ≤1000 cfu/g | USP39 <61> |
| Escherichia coli: | Ukungabikho kwi-1g | USP39 <62> |
| Salmonella spp: | Ukungabikho kwi-25g | USP39 <62> |
| Staphylococcus aureus: | Ukungabikho kwi-1g | |
| IListeria Monocytogenens | Ukungabikho kwi-25g | |
| IiAflatoxins B1 | ≤ 5 ppb -Reg.EC 1881/2006 | USP39 <62> |
| Ii-Aflatoxins ∑ B1, B2, G1, G2 | ≤ 10 ppb -Reg.EC 1881/2006 | USP39 <62> |
Iimpawu zemveliso yeVinca Rosea Extract Vincristine inokubandakanya:
Ukucoceka okuphezulu:Iimveliso zeVincristine zihlala zicocekile kwaye zithobela imigangatho engqongqo yokwenziwa kweziyobisi ukuqinisekisa ukucoceka kunye nokuzinza kwechiza.
Umthombo wokulandeleka:IVincristine idla ngokukhutshwa kwisityalo saseCatharanthus roseus. Inkqubo yokuveliswa kwayo iyalandeleka kwaye ihambelana nokuqokelela kunye neenkcukacha zokuvelisa izinto zonyango lwe-botanical.
Uzinzo kwiChemical:Njenge-alkaloid compound, i-vincristine inozinzo oluhle lweekhemikhali kwaye ifanelekile kwimveliso yamachiza kunye nokugcinwa kwexesha elide.
Umsebenzi wokulwa nethumba:Njengechiza elichasayo, i-vincristine inomsebenzi wokuthintela ukukhula kunye nokusasazeka kweeseli zethumba kwaye ifanelekile kunyango lwee-cancer ezahlukeneyo.
Uqinisekiso lwezonyango:I-Vincristine iye yaqinisekiswa ngokweklinikhi kwaye isetyenziswa ngokubanzi kwizonyango, kunye nenkxaso ethembekileyo ye-pharmacological and clinical effect data.
Ezi mpawu zemveliso zigxininisa umgangatho, umsebenzi, kunye nexabiso lekliniki ye-vincristine njengechiza elibalulekileyo lokulwa nomhlaza.
I-Vinca Rosea Extract Vincristine yaziwa ngokuyintloko ngezicelo zayo zamayeza kunyango lomhlaza kwaye ayiqhelekanga ukunxulumana nezibonelelo zempilo ngokuthe ngqo zokusetyenziswa kwabathengi ngokubanzi. IVincristine, ephuma kwisityalo iVinca rosea, liyeza elinamandla lechemotherapy elisetyenziselwa ukunyanga iintlobo ezahlukeneyo zomhlaza, kubandakanya i-leukemia, i-lymphoma, kunye namathumba aqinileyo. Isebenza ngokuphazamisa ukukhula kweeseli zomhlaza.
Kubalulekile ukuqaphela ukuba iVincristine liyeza elichazwe ngugqirha elilawulwa phantsi kweliso labasebenzi bezempilo, kwaye ukusetyenziswa kwalo kunxulumene neziphumo ebezingalindelekanga kunye nobungozi. Ke ngoko, ayiqhelekanga ukuthengiswa okanye ukusetyenziselwa izibonelelo zayo zempilo ngaphandle kwezicwangciso zeklinikhi.
Usetyenziso oluneenkcukacha lweVinca Rosea Extract Vincristine lubandakanya:
Unyango loMhlaza:IVincristine isetyenziswa ikakhulu kunyango lweentlobo ezahlukeneyo zomhlaza, kubandakanya i-leukemia, i-lymphoma, kunye namathumba aqinileyo. Ilawulwa njengenxalenye ye-chemotherapy regimens ukuthintela ukukhula kweeseli zomhlaza.
UPhando lwaMayeza:Isicatshulwa sisetyenziswa kuphando lwamayeza kuphuhliso lonyango olutsha lomhlaza kunye nokuphononongwa kwendlela yokusebenza kwayo.
Ikhemistri yoNyango:I-Vincristine isebenza njengento exabisekileyo kwintsimi ye-chemistry yonyango, igalelo ekuphuhlisweni kwamachiza amatsha kunye nee-agent zonyango.
I-Biotechnology:Isicatshulwa sinokuqeshwa kwizicelo ze-biotechnological, ezifana nokuveliswa kwe-anticancer formulations kunye neenkqubo zokuhanjiswa kweziyobisi.
Uvavanyo lweklinikhi:I-Vincristine ibandakanyeka kwiimvavanyo zeklinikhi ukuhlola ukusebenza kwayo ekuphatheni iintlobo ezahlukeneyo zomhlaza kunye nokuphanda izicelo ezinokubakho kwezinye iimeko zonyango.
Ukwenziwa kweziyobisi:Isicatshulwa sisetyenziselwa ukuqulunqwa kweemveliso zamachiza, kubandakanywa nezisombululo ezitofwayo kunye nezinye iifom zedosi yonyango lomhlaza.
Ezi zicelo zibonisa iindlela ezahlukeneyo zokusetyenziswa kweVinca Rosea Extract Vincristine kunyango lomhlaza, uphando lwamayeza, kunye nophuhliso lwamachiza.
IVincristine liyeza elinamandla lechemotherapy, kwaye ukusetyenziswa kwalo kunokunxulunyaniswa neziphumo ebezingalindelekanga ezininzi. Ezinye zeempembelelo ezinokuthi zenzeke kwi-Vincristine powder zingabandakanya:
Neurotoxicity:I-Vincristine inokubangela umonakalo kwinkqubo ye-nervous ye-peripheral, ekhokelela kwiimpawu ezifana ne-numbness, i-tingling, kunye nobuthathaka kwimida.
Iziphumo zeGastrointestinal:Iziphumo eziqhelekileyo zesisu esiswini zinokubandakanya isicaphucaphu, ukuhlanza, ukuqunjelwa, kunye neentlungu zesisu.
Uxinzelelo lomongo:I-Vincristine inokucinezela umongo wethambo, okukhokelela ekunciphiseni ukuveliswa kweeseli zegazi, ezinokuthi zibangele i-anemia, ukwanda kwezifo, kunye nokuthambekela ukopha.
Ukulahleka kweenwele:Abanye abantu banokufumana ukulahleka kweenwele okanye ukuncipha kweenwele ngenxa yonyango lweVincristine.
Iintlungu Zomhlathi:I-Vincristine inokubangela uhlobo oluthile lwentlungu eyaziwa ngokuba yi-"vincristine-induced neuropathy-acute-onset," ebonakaliswa yintlungu yomhlathi kunye nobunzima bokugwinya.
Ezinye iziphumo ezinokuthi zibe kho:Imiphumo eyongezelelweyo yecala inokubandakanya ubuthathaka bemisipha, utshintsho kuxinzelelo lwegazi, kunye nokungahambi kakuhle.
Kubalulekile ukuqaphela ukuba olu luhlu lungentla aluphelelanga, kwaye abaqeqeshi bezempilo kufuneka bajonge abantu abafumana i-Vincristine ngazo naziphi na iziphumo ebezingalindelekanga. Iziphumo ezithile ebezingalindelekanga kunye nobunzima bazo bunokwahluka kumntu nomntu. Izigulane kufuneka zixoxe ngemiphumo enokubakho kunye neenkxalabo kunye nomboneleli wabo wezempilo ngaphambi kokuba baqale unyango lweVincristine.
Ukupakishwa kunye neNkonzo
Ukupakishwa
* Ixesha lokuhambisa: Malunga neentsuku ezi-3-5 zomsebenzi emva kwentlawulo yakho.
* Iphakheji: Kwimigqomo yefiber eneeplastiki ezimbini ngaphakathi.
* Ubunzima obuNina: 25kgs/idrum, Ubunzima obuGross: 28kgs/Drum
* Ubungakanani beGubu kunye nomthamo: ID42cm × H52cm, 0.08 m³/ Igubu
* Ugcino: Igcinwe kwindawo eyomileyo nepholileyo, zigcine kude nokukhanya okuqinileyo nobushushu.
* Ubomi beShelf: Iminyaka emibini xa igcinwe kakuhle.
Ukuhambisa ngenqanawe
* I-DHL Express, i-FEDEX, kunye ne-EMS yobuninzi obungaphantsi kwe-50KG, edla ngokubizwa ngokuba yinkonzo ye-DDU.
* Ukuthunyelwa kolwandle ngobuninzi obungaphezu kwe-500 kg; kunye nokuthunyelwa ngomoya kufumaneka kwi-50 kg ngaphezulu.
* Kwiimveliso zexabiso eliphezulu, nceda ukhethe ukuthumela emoyeni kunye ne-DHL express ukhuseleko.
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Iindlela zeNtlawulo kunye nokuhanjiswa
Express
Ngaphantsi kwe-100kg, iintsuku ezi-3-5
Umnyango ukuya emnyango inkonzo lula ukuthatha iimpahla
Ngaselwandle
Ngaphezulu kwe-300kg, malunga neentsuku ezingama-30
Izibuko ukuya kwinkonzo yezibuko i-broker yobuchwephesha efunekayo
NgoMoya
100kg-1000kg, 5-7 Iintsuku
Isikhululo seenqwelomoya ukuya kwinkonzo yesikhululo seenqwelomoya siyafuneka
Iinkcukacha zeMveliso (Itshati yokuHamba)
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