Umgubo weCamptothecin weNdalo (CPT)
I-Natural camptothecin powder (CPT) yi-compound ephuma kumthi we-Camptotheca acuminata, okwaziwa ngokuba "ngumthi ovuyayo" okanye "umthi wobomi." Yi-alkaloid yendalo efunyenwe ineempawu zokulwa nomhlaza. I-Camptothecin kunye ne-derivatives yayo ziye zafundwa ukuze zisetyenziswe kunyango lomhlaza, njengoko zibonakalisiwe ukuba zithintela ukukhula kweeseli zomhlaza ngokuphazamisa ukusebenza kwe-enzyme ebizwa ngokuba yi-topoisomerase I. Oku kuphazamiseka kunokukhokelela ekonakaleni kwe-DNA kwaye ekugqibeleni kufe iiseli kwiiseli zomhlaza. I-natural camptothecin powder iphandwa ngamandla ayo njenge-arhente ye-chemotherapy kwaye inomdla kwishishini leyeza lokuphuhlisa amayeza okulwa nomhlaza. Ukuze ufumane ulwazi oluthe kratya, ungathandabuzi ukunxibelelana ne-grace@email.com.
| Igama lemveliso | ICamptothecin |
| Igama lesiLatini | ICamptotheca Acuminata |
| Elinye Igama | ICamptothecin 98% |
| Inxalenye yeZisetyenzisiweyo | Isiqhamo |
| Inkcazo | 98% |
| Indlela yoVavanyo | I-HPLC |
| Inkangeleko | Umgubo wekristale wenaliti ephuzi okhanyayo |
| Inombolo ye-CAS | 7689/3/4 |
| Ifomula yeMol. | C20H16N2O4 |
| Ubunzima beMol. | 348.35 |
| Beka ubomi kwishelufa | iminyaka eyi-2 |
| Into | Uvavanyo Si-tandard | Uvavanyo Risiphumo | |
| Inkangeleko | Umgubo | Ithobela imithetho | |
| Umbala | Umgubo ophuzi okhanyayo | Ithobela imithetho | |
| Ubungakanani beenxalenye | I-100% idlula nge-80 mesh | Ithobela imithetho | |
| I-Oder | Uphawu | Ithobela imithetho | |
| Incasa | Uphawu | Ithobela imithetho | |
| Ilahleko xa komiswa | ≤5.0% | 2.20% | |
| Intsalela ekutshiseni | ≤0.1% | 0.05% | |
| I-acetone eseleyo | ≤0.1% | Ithobela imithetho | |
| I-Ethanol eseleyo | ≤0.5% | Ithobela imithetho | |
| Iintsimbi zeHeave | ≤10ppm | Ithobela imithetho | |
| Na | ≤0.1% | <0.1% | |
| Pb | ≤3 ppm | Ithobela imithetho | |
| Ipleyiti iyonke | <1000CFU/g | Ithobela imithetho | |
| Imvubelo kunye noMngundo | <100 CFU /g | Ithobela imithetho | |
| E. Coli | Okungalunganga | Ithobela imithetho | |
| I-Salmonella | Okungalunganga | Ithobela imithetho | |
| Isiphelo: Vumelana ne-USP Standard | |||
ICamptothecin yikhompawundi enexabiso elibalulekileyo kwezonyango. Iimpawu zemveliso yayo ziquka:
Ubunyulu obuphezulu:Iimveliso zeCamptothecin zihlala zicocekile kakhulu, nto leyo eqinisekisa ukusebenza kwazo kakuhle kunye nokhuseleko ekuphuhlisweni nasekuvelisweni kwamayeza.
Iimpawu zokulwa nomhlaza:ICamptothecin ifundwe kakhulu kwaye isetyenziswa kwicandelo lamayeza okulwa nomhlaza kwaye inomsebenzi wokulwa nomhlaza. Ke ngoko, enye yeempawu zemveliso ziimpawu zayo zokulwa nomhlaza.
Imithombo yendalo:Ezinye iimveliso ze-camptothecin zikhutshwa kwizityalo zendalo kwaye ke ngoko zifanelekile ukusetyenziswa kwimveliso yemveliso yendalo neyendalo.
Udidi lweyeza:Iimveliso zeCamptothecin zihlala zihlangabezana nemigangatho yomgangatho wamayeza kwaye zifanelekile ukusetyenziswa kumalungiselelo amachiza kwishishini lamayeza.
Izicelo ezinemisebenzi emininzi:Iimveliso zeCamptothecin zingasetyenziswa kuphando nophuhliso lwamayeza, amalungiselelo amayeza, iimveliso zempilo yendalo, nakwezinye iindawo, kwaye zinamathuba amaninzi okusetyenziswa.
Kufuneka kuqatshelwe ukuba i-camptothecin kunye neemveliso zayo kufuneka zilandele ngokungqongqo imigaqo efanelekileyo kunye neenkqubo zokusebenza ezikhuselekileyo ngexesha lokusetyenziswa.
Umgubo we-camptothecin wendalo, onobumsulwa obuyi-98% ubuncinane, unxulunyaniswa neenzuzo ezininzi zempilo, kuquka:
Iimpawu Zokulwa Nomhlaza:ICamptothecin yaziwa ngeempawu zayo ezinamandla zokulwa nomhlaza. Ithintela umsebenzi we-enzyme i-topoisomerase I, ebandakanyeka ekuphindaphindweni kwe-DNA kunye nokwahlulahlula iiseli, nto leyo eyenza ukuba ibe yinxalenye ebalulekileyo kunyango nakuphando lomhlaza.
Umsebenzi we-Antioxidant:ICamptothecin ineempawu ze-antioxidant, ezinokunceda ekunciphiseni uxinzelelo lwe-oxidative kunye nokulwa nee-free radicals emzimbeni, ezinokuba negalelo kwimpilo yonke kunye nokuphila kakuhle.
Iziphumo zokuchasana nokudumba:Ezinye izifundo zibonisa ukuba i-camptothecin inokuba nefuthe lokulwa nokuvuvukala, nto leyo enokuba luncedo ekulawuleni iimeko zokuvuvukala kunye neempawu ezinxulumene noko.
Iziphumo ezinokubakho zokukhusela i-Neuroprotective:Kukho uphando oluvelayo olubonisa ukuba i-camptothecin inokuba neempawu zokukhusela imithambo-luvo, ezinokuba luncedo kwimeko yezifo eziwohlokayo zemithambo-luvo kunye nempilo yengqondo.
Kubalulekile ukuqaphela ukuba nangona umgubo we-camptothecin wendalo unokubonelela ngeenzuzo zempilo, ukusetyenziswa kwawo kunye nokusetyenziswa kwawo kufuneka kuqwalaselwe ngononophelo, kwaye kubalulekile ukubonisana neengcali zempilo ngaphambi kokuba uyisebenzisele naziphi na iinjongo ezinxulumene nempilo.
Umgubo we-camptothecin wendalo onobuncinci be-98% yobumsulwa uneendlela ezahlukeneyo zokusetyenziswa kwicandelo lamayeza, i-nutraceuticals, kunye nophando. Ezinye zeendlela zokusetyenziswa ezineenkcukacha ziquka:
Uphando loMhlaza kunye noPhuhliso lwaMayeza:ICamptothecin ifundwa kakhulu ngenxa yeempawu zayo zokulwa nomhlaza. Lo mgubo ungasetyenziswa kwiilebhu zophando zokufunda ngebhayoloji yomhlaza, uphuhliso lwamayeza, kunye nokwenziwa kwamayeza okulwa nomhlaza.
Iifomyula zamayeza:I-powder yendalo ye-camtothecin ingasetyenziswa ekuphuhlisweni kwamayeza, njengezisombululo ezifakwa kwi-injection, amayeza omlomo, okanye ii-transdermal patches zonyango lweentlobo ezithile zomhlaza.
Iimveliso zeNutraceutical:Lo mgubo ungafakwa kwiimveliso ze-nutraceutical, ezifana nezongezo zokutya, ezijolise ekuboneleleni ngeenzuzo zempilo ezinxulumene neempawu zawo ze-antioxidant kunye ne-anti-inflammatory.
Izicelo zeCosmeceutical:I-Camptothecin ingasetyenziswa ekuphuhlisweni kweemveliso ze-cosmeceutical, ezifana neekhrimu zokulwa nokwaluphala okanye ii-serum, ngenxa yeempawu zayo ezinokubangela i-antioxidant kunye nokukhusela ulusu.
Uphando nophuhliso:Umgubo we-camtothecin wendalo ungasetyenziswa njengesixhobo sophando kwizifundo ezahlukeneyo zesayensi ezinxulumene nomhlaza, i-pharmacology, kunye nekhemistri yamayeza.
Kubalulekile ukuqaphela ukuba ukusetyenziswa kwe-camptothecin kuyo nayiphi na indlela yokusetyenziswa kufuneka kuhambelane nemigaqo yolawulo kwaye kube phantsi kweliso leengcali ezifanelekileyo ngenxa yeempawu zayo ezinamandla zezonyango.
Umgubo we-camptothecin wendalo, oneempawu zawo ezinamandla ze-pharmacological, unokuba neziphumo ebezingalindelekanga, ingakumbi ukuba usetyenziswa ngendlela engafanelekanga okanye ngaphandle kolwalathiso olufanelekileyo lwezonyango. Ezinye iziphumo ebezingalindelekanga zingabandakanya:
Ubuthi:ICamptothecin yaziwa ngokuba nemiphumo emibi, ingakumbi xa isetyenziswa kakhulu. Inokubangela umonakalo kwiiseli eziqhelekileyo kunye neeseli ezinomhlaza, nto leyo ekhokelela kwimiphumo emibi kwizitho ezahlukeneyo zomzimba kunye nezicubu.
Ukuphazamiseka kwesisu:Ukusela i-camptothecin okanye izinto eziphuma kuyo kunokukhokelela kwiingxaki zesisu ezifana nokucaphuka, ukuhlanza, urhudo kunye nentlungu yesisu.
Iziphumo zeHematological:I-Camptothecin inokuchaphazela ukuveliswa kweeseli zegazi, nto leyo ekhokelela kwiimeko ezifana ne-anemia, i-leukopenia, okanye i-thrombocytopenia.
Ubuthathaka bolusu:Ukudibana ngqo ne-camptothecin okanye izisombululo zayo kunokubangela ukurhawuzelelwa lusu okanye iimpembelelo ze-allergy kwabanye abantu.
Ezinye Iziphumo Ezinokubakho:Ezinye iziphumo ebezingalindelekanga zingabandakanya ukulahleka kweenwele, ukudinwa, ubuthathaka, kunye nokuxinana kwamajoni omzimba.
Kubalulekile ukugxininisa ukuba ukusetyenziswa komgubo we-camptothecin wendalo kufuneka kwenziwe phantsi kwesikhokelo seengcali zempilo, ingakumbi iingcali zomhlaza okanye iingcali zekhemesti, ngenxa yempembelelo yayo enamandla yezonyango kunye nobuthi obunokubakho. Ukongeza, abantu kufuneka bazi ngemigaqo yolawulo kunye namanyathelo okhuseleko anxulumene nokuphathwa nokusetyenziswa kwe-camptothecin kunye nezinto eziphuma kuyo.
Ukupakishwa kunye neNkonzo
Ukupakisha
* Ixesha lokuHanjiswa: Malunga neentsuku ezi-3-5 zomsebenzi emva kwentlawulo yakho.
* Iphakheji: Kwiidrum zefayibha kunye neengxowa ezimbini zeplastiki ngaphakathi.
* Ubunzima obupheleleyo: 25kgs/igubu, Ubunzima obupheleleyo: 28kgs/igubu
* Ubungakanani beDrum kunye nomthamo: ID42cm × H52cm, 0.08 m³/ Idrum
* Indawo yokugcina: Igcinwe kwindawo eyomileyo nepholileyo, yigcine kude nokukhanya okunamandla nobushushu.
* Ubomi beShelufu: Iminyaka emibini xa igcinwe kakuhle.
Ukuhambisa ngenqanawe
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* Ukuthunyelwa ngenqanawa ngobuninzi obungaphezulu kwe-500 kg; kwaye ukuthunyelwa ngenqwelomoya kuyafumaneka nge-50 kg engaphezulu.
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Iindlela zokuhlawula kunye nokuhambisa
Express
Ngaphantsi kwe-100kg, iintsuku ezi-3-5
Inkonzo yokungena emnyango kulula ukuyithatha impahla
Ngaselwandle
Ngaphezulu kwe-300kg, malunga neentsuku ezingama-30
Kufuneka umthengisi weenkonzo zokucoca iinqanawa ukusuka kwelinye izibuko ukuya kwelinye
Ngomoya
100kg-1000kg, iintsuku ezi-5-7
Kufuneka umthengisi weenkonzo zokucoca izikhululo zeenqwelo-moya ukusuka kwisikhululo seenqwelo-moya ukuya kwisikhululo seenqwelo-moya
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