I-rotundine ecocekileyo yeRotundine (L-Terahydropatine, l-th-th)
I-rotundine, ekwabizwa ngokuba yi-l-terarahydropatine (L-T-th-th), yingqungquthela yepropathi ye-phammacolocal echaphazela inkqubo ye-nervacovalcular kunye nenkqubo yentliziyo. Kuxelwe ukuba ibe ne-Analgesic, i-sedative, i-hypnotic, kunye ne-intiyotic. Ukongeza, kubonisiwe ukuba ube nefuthe lokukhusela kwi-cerebral kunye ne-myocardial ye-mychemia-reperfusion. I-rotundine ikwaziwa ngokubanakho ukubakho kokuchasana nokungavisisani kweeseli zomhlaza kunye neeseli zayo zokubhloka.
Inokufunyanwa kwi-tubers kaStephania Tetrandra kunye neCorydalis yanhusuo, okanye ngeendlela zeSynthesic. I-Synthethed ukusuka kwi-tetraratantine ngokuncitshiswa, ukucoca, kunye nokuphendula okuphezulu. I-Idirancinated tarahydropamatine inokuveliswa kwi-tetrahydrofaltine nge-alkalization kunye ne-oxidation ye-synthesi ephindaphindiweyo.
Kwi-pharmacokinetics, i-romeundine ingene emva kolawulo ngomlomo kwaye ihanjiswa ngokuyintloko kwi-tishu, ilandelwa yimiphunga, isibindi, kunye nezintso. Kuyikhuphela ikakhulu izintso. Izifundo ezikwiintonga kunye nemivundla zibonise ukuba iRogondine inokungena kumqobo wegazi kwaye ingenise izicubu zobuchopho, ngengqondo yobuchopho iphantsi kuneengcinezelo zegazi emva kweeyure ezi-2.
Kwiziphumo ezibi, i-rotundine inokubangela ukozela, isiyezi, ukudinwa, isicaphucaphu, kwaye ngamanye amaxesha ukungakhathali. Amanyathelo okhuseleko abandakanya ukunqanda ukusetyenziswa ekukhulelweni nasekuqaphele, ukuba bakwazi ukunyamezelana nokusetyenziswa kwexesha elide, kwaye basebenzise isilumkiso xa besenza uxinzelelo lwendlela yokuxinana ne-dosioge xa kukho imfuneko.
Kwisishwankathelo, i-rotundine yindawo enezihloko ezahlukeneyo zephamma, kwaye iipropathi zayo zenza ukuba kube ngumdla kuphando olwahlukileyo, kubandakanya nolawulo lweentlungu, impilo yentliziyo kunye nonyango lwentliziyo, kunye nonyango lwentliziyo kunye nonyango lwentliziyo kunye nonyango lwentliziyo, kunye nonyango lwentliziyo. Ngolwazi oluthe kratyagrace@biowaycn.com.
Intlungu yentlungu:I-rotundine ibonisiwe ukuba inepropathi ye-analgesic, iyenza isebenze ekunciphiseni iintlungu kunye nokungalunganga.
Iziphumo ze-anti-insulmatory:I-rotundine ibonise iipropathi ezichasene ne-anti-insulmatory, ezinokunceda ukunciphisa ukuvuvukala kunye neempawu ezinxulumene nazo.
Ukuphumla kunye ne-sedation:I-rotundine isetyenziselwe ukukhuthaza ukuphumla kunye ne-sedation, isenza ibe yingenelo yokulawula uxinzelelo kunye noxinzelelo.
Umsebenzi we-antioxidant:I-rotundine ifunyenwe ukubonisa iziphumo ze-antisoxidant, ezinokunceda ukukhusela iiseli zomonakalo obangelwe zii-radicals zasimahla.
Inokubakho kunyango lwekhoboka:Olunye uphando lubonisa ukuba iRotudine inokubangela ukuba kulawulwe iziyobisi kunye neempawu zokurhoxa, ngakumbi ukuba kuxhomekeke kwi-opioid.
Izibonelelo ze-Gastrointentinal:I-rotundine ifundwe ngenxa yokunciphisa imiba ye-gestrointentinal, njenge spasms kunye nengxaki.
| Uhlalutyo | Ukucaciswa |
| I-assay | I-Tetrarahydropatine ≥98% |
| Imbonakalo | I-polle ye-tyheli emfutshane yomgubo omhlophe |
| I-ash | ≤0.5% |
| Ukufuma | ≤5.0% |
| Izibulala-zinambuzane | Engalunganga |
| Izinyithi ezinzima | ≤10ppm |
| Pb | ≤2.0ppm |
| As | ≤2.0ppm |
| Ivumba | Phawula |
| Ubungakanani bentsundu | I-100% nge-80 mesh |
| Microbiological : | |
| Iyonke yeBacteria | ≤1000cfu / g |
| Fungu | ≤100cfu / g |
| Salmgosse | Engalunganga |
| Coli | Engalunganga |
IRotundine ineenkqubo zamashishini aliqela, kubandakanya:
Ishishini lamachiza:I-rotundine isetyenziswa kumzi-mveliso wamachiza ngenxa ye-analgesic yayo, ye-sedative, kunye nentswela-mali. Inokubandakanywa kumayeza kulawulo lweentlungu kunye noncedo loxinzelelo.
Ukhathalelo lwempilo kunye nentlalo-ntle:Ngenxa yezibonelelo zayo zezempilo ezixeliweyo, i-rogundine inokusetyenziswa kwiimveliso zempilo kunye nempilo entle ejolise ekukhuthazeni ukuphumla nokulawula iintlungu.
Uphando nophuhliso:I-rotundine inomdla kuphando kunye neenzame zophuhliso ezigxile kwimpilo yentliziyo, unyango lomhlaza, kunye neemeko ze-neurological ngenxa yeziphumo zayo ezixeliweyo kwezi nkqubo.
I-NTRACHICALS:Kukho ukubandakanywa kwe-rotundine kwiimveliso zesondlo ezenzelwe ukuxhasa impilo kunye nentlalo-ntle ngokubanzi.
Kubalulekile ukuba uqaphele ukuba izicelo ezithile ze-rotunine zingahluka ngokusekwe kwimvume yolawulo kunye nophando oluqhubekayo kwishishini ngalinye.
Iimveliso zethu zenziwa zisebenzisa amanyathelo aphantsi olawulo lomgangatho kwaye zilandele imigangatho ephezulu yeenkqubo zemveliso. Sibeka phambili ukhuseleko kunye nomgangatho wemveliso yethu, ukuqinisekisa ukuba ifezekisa iimfuno zomthetho kunye nezatifikethi zeshishini. Oku kuzinikela kwimigangatho esemgangathweni yokuseka ukuthembana kunye nokuzithemba ekuthembekeni kwemveliso yethu. Inkqubo yemveliso ngokubanzi yile ilandelayo:
Ukugcinwa:Gcina kwindawo epholileyo, eyomileyo necocekileyo, husela ekumakeni kunye nokukhanya ngokuthe ngqo.
Iphakheji ye-Bulk:20~25kg / idrum.
Ixesha lokukhokhela:Iintsuku ezisi-7 emva kolungelelwano lwakho.
Beka ubomi kwishelufa:iminyaka eyi-2.
I-tesk:Inkcazo ngokwezifiso inokufezekiswa.
Chaza
Ngaphantsi kwe-100kg, i-3-5 yantwana
Umnyango kwinkonzo yendlu kulula ukuthabatha iimpahla
Ngolwandle
Ngaphezulu kwe-300kg, malunga neentsuku ezingama-30
I-Port ukuya kwi-Port Point Conseker Bricker efunekayo
Ngomoya
I-100kg-1000kg, 5-7 days
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