Umgubo wendalo ococekileyo we-cipharanther
Umgubo wendalo ococekileyo we-cipharantheryindlela efihliweyo ye-biptharandline enemigangatho, ethathwe kwisityalo uStephania Cipherantha. Yi-bisBenzysoline yendalo i-bisbennorine alkaloid kwaye isetyenziswe ngokwesiko kwi-Chinese kunye namayeza e-chinese ye-Chinaccological, kuquka ne-antioxicologer, kubandakanya ne-antioculant, i-anti-insumotory, imisebenzi ye-antinmoral, kunye ne-antitmoral, kunye nemisebenzi ye-antiitmural, kunye nemisebenzi ye-antinO.
Kwimeko yeCovided-19, uCepharanthine ubonakalisile ukuthembisa okuchasene nokuchasana ne-19. Ibonise ukuthintelwa okukhulu kwentanda yentsholongwane ye-SARS-2, intsholongwane enoxanduva lweCovide-19. I-IC50 kunye neenqobo zokuxabiseka kwe-IC80 ze-fuphonthine nxamnye ne-SARS-2 ngu-1.90 μm no-4.4m, ngokwahlukeneyo.
Ngapha koko, i-fupharanthenene iboniswe ukubuyela umva kwi-P-GyCoferikin yeMultic (P-GP) yeeseli ezininzi kwi-K562 yeeseli kunye nokonyusa ubuntununtunu lwamachiza ee-anticialr kwi-Xenograft Models. Ikwabonisa iziphumo zokungavumi kwi-Cytochrome yoLuntu ye-p450 i-enzymes efana ne-CYP34, i-cyp24, kunye ne-cyp2c9.
Luhlobo oluhlanganisiweyo lwecandelo, elinokusetyenziselwa iinjongo ezahlukeneyo, kubandakanya nophando, uphuhliso lwamayeza, kunye nokuqulunqwa.
Ifomu yomgubo ivumela ukuphatha ngokulula, ukulinganisa, nokuxuba kwe-biparanthine, iyenza lula ukusetyenziswa kwizicelo ezahlukeneyo. Ingasetyenziselwa ukuphuculwa kwamayeza, izongezelelo, okanye ezinye iindlela ezisebenzisa ubuchule obunokubakho kwe-bipatranthente.
Umgubo wendalo ococekileyo we-cipharantherNgokwesiqhelo ifunyenwe ngokukhutshelwa kunye neenkqubo zokucoca ukuqinisekisa inqanaba eliphezulu lobucoceko kunye nomgangatho. Oku kuqinisekisa ukuba umgubo ukhululekile, ukukhululeka, ungcoliseko, okanye ezinye izinto ezinokuthi zichaphazele ukusebenza kwalo okanye ukhuseleko.
| Into | Ukucaciswa | Iziphumo zovavanyo |
| Imbonakalo | Umgubo omhlophe, i-odor engathathi hlangothi, i-hygroscopic kakhulu | Ivumelana |
| Isazisi | I-TLC: Isisombululo esisezantsi kunye nesisombululo sovavanyo spot kunye ne-rf | Ivumelana |
| I-Assay (isiseko esomileyo) | I-98.0% - 102.0% | I-98.1% |
| Ikhethekileyo | -2.4 ° ~ -2.8 ° | -2.71 ° |
| PH | 4.5 ~ 7.0 | 5.3 |
| Izinyithi ezinzima (njenge-PB) | ≤10ppm | <I-10ppm |
| As | ≤1ppm | Ayifunyenwanga |
| Pb | ≤0.5PPM | Ayifunyenwanga |
| Cd | ≤1ppm | Ayifunyenwanga |
| Hg | ≤0.1ppm | Ayifunyenwanga |
| Into enxulumene noko | Ibala ayisiyo enkulu kunomgangatho Indawo yesisombululo | Akukho ndawo |
| I-SOLLDUMS SOLLVevent | <0.5% | Dibanisa |
| Umxholo wamanzi | <2% | I-0.18% |
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(3) Umgubo ulungele iinjongo ezahlukeneyo, kubandakanya nophando, uphuhliso lwamayeza, kunye nokuqulunqwa.
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(7) Iphandwe ngenxa yezibonelelo zentliziyo ezinokubakho zentliziyo, njengokuphucula ukuhamba kwegazi kunye nokuxhasa impilo yentliziyo.
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Ibonisa isithembiso kwintsimi ye-dermatology, enokubakho ukuba neempawu zokukhusela ulusu nelokhwe.
(1) Ishishini lamachiza
(2) I-Nutraceuticals kunye nezongezo zokutya
(3) i-cosmetics kunye ne-shycare
(4) Unyango lwemveli
(5) Uphando kunye nophuhliso
(1) Ukulinywa kwezityalo:Izinto eziluhlaza, izityalo zaseStephania cipharantha, zikhule kwiimeko ezifanelekileyo zolimo.
(2) Ukuvuna:Izityalo ezivuthiweyo zikhethwe ngesandla ngenyameko ukuqinisekisa umgangatho.
(3) Ukomisa:Izityalo ezivunyiweyo zomile zisebenzisa iindlela zesiko okanye iindlela zangoku zokususa umswakama.
(4) Ukukhupha:Izityalo ezomileyo zityalwa kwi-powder entle kwaye iphantsi kosulelo usebenzisa izinyibilikisi njenge-ethanol okanye emanzini.
(5) ukugcwalisa:Isicatshulwa siyahluzwa ukuba sisuse ukungafezekisi kwaye sifumane isisombululo esicacileyo.
(6) Uxinzelelo:I-filling igxilwe ukuba isuse i-Solvent ye-SOLLT igqithisileyo kwaye yonyusa ukugxila kwe-chaerharantheenthine.
(7) Ukucocwa:I-Centrations i-subles isebenza ngakumbi iinkqubo zokucamngca ezifana ne-chromatography okanye i-crystallization ukufumana i-celatranthene ecocekileyo.
(8) Ukomisa:I-Ceparanthine ehlanjululwe inene iyomisiwe isuse nakuphi na ukufuma kwentsalela.
(9) I-PlawnI-cephonthine eyomileyo ye-cephonthine iconjululwa ngumgubo ococekileyo.
(10) Ulawulo loMgangatho:Umgubo uphakathi kuvavanyo olungqongqo ukuqinisekisa ukuba lihlangabezana nemigangatho esemgangathweni yobunyulu, isimo sengqondo kunye nokhuseleko.
(11) Ukupakisha:Imveliso yokugqibela ipakishwe kwizitya zomoya zokugcina ubomi bayo kunye nobomi beshelup.
(12) Ukugcinwa:Ipowder ye-cipharanther ye-ciesharanther ye-ciesharanther igcinwe kwiimeko ezifanelekileyo zokugcina uzinzo lwayo kunye nokusebenza kakuhle.
Qaphela: Eyona nkqubo yemveliso inokwahluka ngokuxhomekeka kumenzi womenzi kunye neemfuno ezithile.
Ukugcinwa: Gcina kwindawo epholileyo, eyomileyo necocekileyo, ikhusele ekuthambekeni nasekukhanyiseni ngokuthe ngqo.
Iphakheji ye-Bulk: 25kg / idrum.
Ixesha le-Comhsho: kwiintsuku ezisi-7 emva kolungelelwano lwakho.
Ubomi beshelup: iminyaka emi-2.
I-IRGUCHE: Inkcazo ngokwesiko nayo inokufezekiswa.
I-20kg / ibhegi ye-500kg / ipallet
Ukuphinda kuqhekezwe ukupakisha
Ukhuseleko lwezinto
Chaza
Ngaphantsi kwe-100kg, i-3-5 yantwana
Umnyango kwinkonzo yendlu kulula ukuthabatha iimpahla
Ngolwandle
Ngaphezulu kwe-300kg, malunga neentsuku ezingama-30
I-Port ukuya kwi-Port Point Conseker Bricker efunekayo
Ngomoya
I-100kg-1000kg, 5-7 days
Isikhululo senqwelomoya esiya kwisikhululo senqwelomoya senkonzo yeSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seSikhululo seNkonzo esiyifunayo
Umgubo wendalo ococekileyo we-cipharantherIqinisekisiwe ngesatifikethi se-ISO, isatifikethi seHalal, kunye neSatifikethi se-Kosher.
Iziphumo ebezingalindelekanga ze-cipharantter yendalo ecocekileyo yendalo inokwahluka kumntu umntu kwaye ayinakufumana wonke umntu. Ezinye iziphumo ebezinokubakho ezichaziweyo zibandakanya:
Imicimbi yeJastrointentinal:Abanye abantu banokufumana ukungakhathazeki kwe-gestrointentinal, njengamawaka-nausea, iintlungu zesisu, isifo sohudo, okanye isithintelo.
I-Allforgic Reance:Kwiimeko ezinqabileyo, ukuphendula okungafunekiyo kunokuthi zenzeke, kukhokelela kwiimpawu ezinjengolusu, ukurhangqa, ukudumba, okanye ubunzima bokuphefumla. Ukuba ufumana nakuphi na ukuphendula okungafunekiyo, ukuyeka umsebenzi kwaye ufune unyango kwangoko.
Uxinzelelo lwegazi kunye nenqanaba lentliziyo:I-Cepharanthine inokuba nefuthe kuxinzelelo lwegazi kunye nenqanaba lentliziyo. Abantu abaneemeko zentliziyo zangaphambili okanye abo bathatha amayeza ommiselo wegazi kufuneka balumke kwaye banxibelelane nempilo yabo yezempilo ngaphambi kokuba basebenzise i-bietharantheenthine.
Ukudibana kwamayeza:I-CePharanthine inokusebenzisana namayeza athile, anjengee-anticoants okanye amachiza ka-Antipalet. Olu nxibelelwano lunokuchaphazela ukubekwa kwegazi okanye ukwandisa umngcipheko wokwaphuka. Kuyimfuneko ukwazisa ubungcali bezempilo malunga namayeza akho ukuba uyawathatha ngaphambi kokusebenzisa i-celatranthe.
Ezinye iziphumo ezinokubakho:Ngelixa kukho izifundo ezinomda kwiziphumo ezithile ze-piesharantheenthe, abanye abasebenzisi baxele ukuba kuphazamise ukuphazamiseka, isiyezi, intloko, okanye utshintsho ekuthandeni.
Kubalulekile ukuba uqaphele ukuba iziphumo ebezingalindelekanga zange ziphesheya, kwaye amava akho anokwahluka. Ukuba ufumana nakuphi na malunga nefuthe lecala eliqinisekileyo ngelixa uthatha i-biparanthine, kubalulekile ukufuna unyango kwaye ujongene nengcali yezempilo.
