I. Intshayelelo
IiPhospholipidsZizinto ezibalulekileyo kwiimembrane zebhayoloji kwaye zidlala indima ebalulekileyo kwiinkqubo ezahlukeneyo zefiziyoloji. Ukuqonda ulwakhiwo kunye nomsebenzi wazo kubalulekile ekuqondeni ubunzima bebhayoloji yeseli kunye neyemolekyuli, kunye nokubaluleka kwazo kwimpilo yoluntu kunye nezifo. Olu qwalaselo lubanzi lujolise ekujongeni ubunjani obuntsonkothileyo beephospholipids, ukuhlola inkcazo kunye nolwakhiwo lwazo, kunye nokugxininisa ukubaluleka kokufunda ezi molekyuli.
A. Inkcazo kunye nolwakhiwo lweePhospholipids
IiPhospholipids ludidi lwee-lipids eziqulathe ii-fatty acid chain ezimbini, iqela le-phosphate, kunye nomqolo we-glycerol. Ulwakhiwo olukhethekileyo lwee-phospholipids lubenza bakwazi ukwenza i-lipid bilayer, isiseko see-membranes zeseli, kunye nemisila ye-hydrophobic ejonge ngaphakathi kunye neentloko ze-hydrophilic ezijonge ngaphandle. Olu lungiselelo lubonelela ngomqobo onamandla olawula ukuhamba kwezinto eziya nokuphuma kwiseli, ngelixa likwalawula iinkqubo ezahlukeneyo zeseli ezifana nokuhambisa kunye nokuhambisa.
B. Ukubaluleka Kokufunda NgeePhospholipids
Ukufunda ii-phospholipids kubalulekile ngezizathu ezahlukeneyo. Okokuqala, zibalulekile kwisakhiwo kunye nomsebenzi wee-membranes zeseli, zichaphazela ukugeleza kwe-membrane, ukungena kwamanzi, kunye nokuzinza. Ukuqonda iimpawu ze-phospholipids kubalulekile ekutyhileni iindlela ezisisiseko seenkqubo zeseli ezifana ne-endocytosis, i-exocytosis, kunye nokudluliselwa kwesignali.
Ngaphezu koko, ii-phospholipids zinefuthe elibalulekileyo kwimpilo yabantu, ngakumbi malunga neemeko ezifana nesifo sentliziyo, iingxaki ze-neurodegenerative, kunye ne-metabolic syndromes. Uphando malunga nee-phospholipids lunokubonelela ngengqiqo malunga nophuhliso lweendlela ezintsha zonyango kunye nokungenelela kokutya okujolise kule miba yezempilo.
Ukongeza, ukusetyenziswa kwe-phospholipids kwimizi-mveliso nakwezorhwebo kwiindawo ezifana namayeza, i-nutraceuticals, kunye ne-biotechnology kugxininisa ukubaluleka kokuphucula ulwazi lwethu kweli candelo. Ukuqonda iindima ezahlukeneyo kunye neempawu ze-phospholipids kunokukhokelela ekuphuhlisweni kweemveliso ezintsha kunye netekhnoloji enefuthe elibanzi kwimpilo-ntle yoluntu kunye nophuhliso lwetekhnoloji.
Ngamafutshane, uphando lwee-phospholipids lubalulekile ekutyhileni isayensi entsonkothileyo engasemva kwesakhiwo kunye nomsebenzi weeseli, ukuhlola impembelelo yazo kwimpilo yabantu, kunye nokusebenzisa amandla azo kwizicelo ezahlukeneyo zoshishino. Olu phononongo olupheleleyo lujolise ekukhanyiseni uhlobo olunemiba emininzi lwee-phospholipids kunye nokubaluleka kwazo kwiindawo zophando lwebhayoloji, impilo-ntle yabantu, kunye nokuvelisa izinto ezintsha kwezobuchwepheshe.
II. Imisebenzi yebhayoloji yePhospholipids
IiPhospholipids, icandelo elibalulekileyo lee-membrane zeseli, zidlala indima ezahlukeneyo ekugcineni ulwakhiwo lweseli kunye nomsebenzi walo, kunye nokuchaphazela iinkqubo ezahlukeneyo ze-physiological. Ukuqonda imisebenzi yebhayoloji yeephospholipids kunika ukuqonda ngokubaluleka kwazo kwimpilo yoluntu nakwizifo.
A. Indima kwiSakhiwo kunye nomsebenzi weMembrane yeSeli
Umsebenzi oyintloko webhayoloji wee-phospholipids kukufaka isandla kwisakhiwo kunye nomsebenzi wee-membranes zeseli. Ii-Phospholipids zenza i-lipid bilayer, isakhelo esisisiseko see-membranes zeseli, ngokuzihlela ngokwazo ngemisila yazo e-hydrophobic ngaphakathi kunye neentloko ze-hydrophilic ngaphandle. Olu lwakhiwo lwenza i-membrane engakwazi ukungena ngaphakathi elawula ukudlula kwezinto ngaphakathi nangaphandle kweseli, ngaloo ndlela igcina i-homeostasis yeseli kwaye iququzelele imisebenzi ebalulekileyo efana nokufunxwa kwezondlo, ukukhutshwa kwenkunkuma, kunye nokuhanjiswa kwemiqondiso yeseli.
B. Ukuhambisa imiqondiso kunye nonxibelelwano kwiiseli
IiPhospholipids zikwasebenza njengezinto ezibalulekileyo zeendlela zokubonisana kunye nonxibelelwano phakathi kweseli neseli. Iiphospholipid ezithile, ezifana ne-phosphatidylinositol, zisebenza njengezinto ezizandulela iimolekyuli zokubonisana (umz., i-inositol trisphosphate kunye ne-diacylglycerol) ezilawula iinkqubo ezibalulekileyo zeseli, kubandakanya ukukhula kweseli, ukwahlukana, kunye ne-apoptosis. Ezi molekyuli zokubonisana zidlala indima ebalulekileyo kwiindlela ezahlukeneyo zokubonisana zangaphakathi kweseli kunye ne-intercellular, zichaphazela iimpendulo ezahlukeneyo ze-physiological kunye nokuziphatha kweseli.
C. Igalelo kwiMpilo yoBongo kunye noMsebenzi woBuchongo
IiPhospholipids, ingakumbi i-phosphatidylcholine, kunye ne-phosphatidylserine, zininzi engqondweni kwaye zibalulekile ekugcineni ulwakhiwo kunye nomsebenzi wayo. IiPhospholipids zinegalelo ekwakhiweni nasekuzinzeni kwee-neuronal membranes, zinceda ekukhululweni nasekufunyanweni kwee-neurotransmitter, kwaye zibandakanyeka kwi-synaptic plasticity, ebaluleke kakhulu ekufundeni nasekukhumbuleni. Ngaphezu koko, ii-phospholipids zidlala indima kwiinkqubo zokukhusela i-neuroprotective kwaye ziye zabandakanyeka ekujongeni ukuwohloka kwengqondo okunxulunyaniswa nokwaluphala kunye neengxaki ze-neurological.
D. Impembelelo kwiMpilo yeNtliziyo kunye noMsebenzi weNtliziyo
Iiphospholipids zibonakalise impembelelo ebalulekileyo kwimpilo yentliziyo kunye nokusebenza kwentliziyo. Zibandakanyeka kwisakhiwo kunye nomsebenzi wee-lipoproteins, ezithutha i-cholesterol kunye nezinye ii-lipids egazini. Ii-phospholipids ezikwii-lipoproteins zinegalelo ekuzinzeni nasekusebenzeni kwazo, zichaphazela imetabolism ye-lipid kunye ne-cholesterol homeostasis. Ukongeza, ii-phospholipids ziye zafundwa ukuze kufunyanwe amandla azo okuguqula iiprofayili ze-lipids zegazi kunye nokunciphisa umngcipheko wezifo zentliziyo, ziqaqambisa impembelelo yazo enokubakho yonyango ekulawuleni impilo yentliziyo.
E. Ukubandakanyeka kwiMetabolism yeLipid kunye neMveliso yamandla
IiPhospholipids zibalulekile kwimetabolism ye-lipid kunye nemveliso yamandla. Zibandakanyeka ekuhlanganisweni nasekuqhekekeni kwee-lipids, kuquka ii-triglycerides kunye ne-cholesterol, kwaye zidlala indima ebalulekileyo ekuthuthweni nasekugcinweni kwe-lipids. IiPhospholipids zikwanegalelo kumsebenzi we-mitochondrial kunye nemveliso yamandla ngokubandakanyeka kwazo kwi-phosphorylation ye-oxidative kunye nekhonkco lothutho lwe-electron, nto leyo egxininisa ukubaluleka kwazo kwimetabolism yamandla eseli.
Ngamafutshane, imisebenzi yebhayoloji yeephospholipids inamacandelo amaninzi kwaye iquka iindima zayo kwisakhiwo kunye nomsebenzi we-membrane yeseli, ukunxibelelana kunye nokunxibelelana kwiiseli, igalelo kwimpilo yengqondo kunye nomsebenzi wokuqonda, impembelelo kwimpilo yentliziyo kunye nomsebenzi wentliziyo, kunye nokubandakanyeka kwimetabolism yamafutha kunye nemveliso yamandla. Olu qwalaselo lubanzi lubonelela ngokuqonda okunzulu ngemisebenzi eyahlukeneyo yebhayoloji yeephospholipids kunye nefuthe layo kwimpilo kunye nokuphila kakuhle kwabantu.
III. Iingenelo zeMpilo zePhospholipids
Iiphospholipids zizinto ezibalulekileyo kwiimembrane zeseli ezineendima ezahlukeneyo kwimpilo yomntu. Ukuqonda iingenelo zempilo zeephospholipids kunokukhanyisa ukusetyenziswa kwazo okunokwenzeka kunyango kunye nesondlo.
Iziphumo kwiNqanaba leCholesterol
Iiphospholipids zidlala indima ebalulekileyo kwimetabolism yamafutha kunye nokuthuthwa kwawo, nto leyo echaphazela ngokuthe ngqo amanqanaba e-cholesterol emzimbeni. Uphando lubonise ukuba iiphospholipids zinokuguqula imetabolism ye-cholesterol ngokuchaphazela ukwenziwa, ukufunxwa, kunye nokukhutshwa kwe-cholesterol. Iiphospholipids ziye zaxelwa ukuba zinceda ekuhlanganiseni nasekunyibilikiseni amafutha okutya, ngaloo ndlela zinceda ekufunxeni i-cholesterol emathunjini. Ukongeza, iiphospholipids zibandakanyeka ekwakhiweni kwee-lipoproteins ezixineneyo (HDL), ezaziwa ngendima yazo ekususeni i-cholesterol engaphezulu egazini, ngaloo ndlela zinciphisa umngcipheko we-atherosclerosis kunye nezifo zentliziyo. Ubungqina bubonisa ukuba iiphospholipids zinokuba namandla okuphucula iiprofayili ze-lipid kwaye zinegalelo ekugcineni amanqanaba e-cholesterol asempilweni emzimbeni.
Iipropati zokuNqanda ukuGcina iOksijini
IiPhospholipids zibonisa iipropati ze-antioxidative ezinegalelo kwimiphumo yazo eyingenelo kwimpilo. Njengezinto ezibalulekileyo kwiimembrane zeseli, iiphospholipids zichaphazeleka kumonakalo we-oxidative yi-free radicals kunye neentlobo ze-oxygen ezisebenzayo. Nangona kunjalo, iiphospholipids zinamandla e-antioxidative angaphakathi, zisebenza njengezihluzi zee-free radicals kwaye zikhusela iiseli kuxinzelelo lwe-oxidative. Izifundo zibonise ukuba iiphospholipids ezithile, ezifana ne-phosphatidylcholine kunye ne-phosphatidylethanolamine, zinokunciphisa ngokufanelekileyo umonakalo we-oxidative kwaye zithintele i-lipid peroxidation. Ngaphezu koko, iiphospholipids ziye zabandakanyeka ekuphuculeni inkqubo yokukhusela i-antioxidant ngaphakathi kweeseli, ngaloo ndlela zisebenza ngempembelelo yokukhusela kumonakalo we-oxidative kunye ne-pathologies ezinxulumene noko.
Izicelo ezinokubakho zonyango kunye nezondlo
Iingenelo ezikhethekileyo zempilo ze-phospholipids ziye zavelisa umdla kwizicelo zazo zonyango nezondlo ezinokubakho. Unyango olusekelwe kwi-phospholipid luyaphononongwa ngenxa yamandla alo ekulawuleni iingxaki ezinxulumene ne-lipid, ezifana ne-hypercholesterolemia kunye ne-dyslipidemia. Ngaphezu koko, ii-phospholipids zibonise ithemba ekukhuthazeni impilo yesibindi kunye nokuxhasa ukusebenza kwesibindi, ngakumbi kwiimeko ezibandakanya imetabolism ye-lipid yesibindi kunye noxinzelelo lwe-oxidative. Ukusetyenziswa kwesondlo se-phospholipids kuye kwabonwa kwicandelo lokutya okusebenzayo kunye nezongezo zokutya, apho kuphuhliswa khona iifomyula ezityebileyo ze-phospholipid ukuphucula ukumuncwa kwe-lipid, ukukhuthaza impilo yentliziyo, kunye nokuxhasa impilo-ntle iyonke.
Ukuqukumbela, iingenelo zempilo zeephospholipids ziquka imiphumo yazo kumanqanaba e-cholesterol, iipropati ze-antioxidative, kunye nokusetyenziswa kwazo okunokwenzeka kunyango kunye nesondlo. Ukuqonda indima ebanzi yeephospholipids ekugcineni i-homeostasis yomzimba kunye nokunciphisa umngcipheko wesifo kubonelela ngengqiqo ebalulekileyo ngokubaluleka kwazo ekukhuthazeni impilo kunye nokuphila kakuhle kwabantu.
IV. Imithombo yeePhospholipids
Iiphospholipids, njengezinto ezibalulekileyo ze-lipid kwi-membranes zeseli, zibalulekile ekugcineni ulungelelwaniso lwesakhiwo kunye nokusebenza kweeseli. Ukuqonda imithombo yeephospholipids kubaluleke kakhulu ekuqondeni ukubaluleka kwazo kwisondlo nakwimisebenzi yemizi-mveliso.
A. Imithombo yokutya
Imithombo Yokutya: Iiphospholipids zinokufunyanwa kwimithombo eyahlukeneyo yokutya, eminye yemithombo etyebileyo yi-egg yolk, inyama ye-organ, kunye neesoya. Ii-egg yolk zininzi kakhulu kwi-phosphatidylcholine, uhlobo lwe-phospholipid, ngelixa iisoya ziqulethe i-phosphatidylserine kunye ne-phosphatidylinositol. Eminye imithombo yokutya ye-phospholipids ibandakanya iimveliso zobisi, ii-peanuts, kunye nembewu yelanga.
Ukubaluleka Kwebhayoloji: Iiphospholipids zokutya zibalulekile kwisondlo somntu kwaye zidlala indima ebalulekileyo kwiinkqubo ezahlukeneyo zebhayoloji. Nje ukuba zityiwe, iiphospholipids ziyagaywa kwaye zifunxwe emathunjini amancinci, apho zisebenza njengeebhloko zokwakha iimembrane zeseli zomzimba kwaye zinegalelo ekwakhiweni nasekusebenzeni kwee-lipoprotein particles ezithutha i-cholesterol kunye ne-triglycerides.
Iimpembelelo zeMpilo: Uphando lubonise ukuba ii-phospholipids zokutya zinokuba neengenelo zempilo, kubandakanya ukuphucula ukusebenza kwesibindi, ukuxhasa impilo yengqondo, kunye negalelo kwimpilo yentliziyo. Ngaphezu koko, ii-phospholipids ezivela kwimithombo yolwandle, njengeoyile ye-krill, ziye zafumana ingqalelo ngenxa yeempawu zazo zokulwa nokuvuvukala kunye ne-antioxidant.
B. Imithombo yezeMveliso kunye neyeMithi
Ukutsalwa kweMizi-mveliso: IiPhospholipids zikwafunyanwa kwimithombo yemizi-mveliso, apho zitsalwa khona kwizinto zendalo ezinje ngeesoya, imbewu yelanga, kunye nerapeseeds. Ezi phospholipids emva koko ziyacutshungulwa kwaye zisetyenziswe kwizicelo ezahlukeneyo zoshishino, kubandakanya ukuveliswa kwee-emulsifiers, iziqinisi, kunye nee-encapsulation agents zokutya, amayeza, kunye nemizi-mveliso yezithambiso.
Ukusetyenziswa Kwamayeza: IiPhospholipids zidlala indima ebalulekileyo kushishino lwamayeza, ingakumbi kwiinkqubo zokuhanjiswa kwamayeza. Zisetyenziswa njengezinto ezincedisayo ekuqulunqweni kweenkqubo zokuhanjiswa kwamayeza ezisekelwe kwi-lipid ukuphucula ukufumaneka, uzinzo, kunye nokujoliswa kweekhompawundi zamayeza. Ukongeza, iiphospholipids ziye zahlolwa ngenxa yamandla azo ekuphuhliseni abathwali bamayeza abatsha bokuhanjiswa okujoliswe kubo kunye nokukhululwa okuqhubekayo kwezonyango.
Ukubaluleka kwiShishini: Ukusetyenziswa kwee-phospholipids kwimizi-mveliso kudlulela ngaphaya kwamayeza ukuya kubandakanywa nokusetyenziswa kwazo kwimveliso yokutya, apho zisebenza njengee-emulsifiers kunye ne-stabilizers kwiintlobo ngeentlobo zokutya okucutshungulwayo. Ii-phospholipids zikwasetyenziswa kwimveliso yokhathalelo lomntu kunye neemveliso zobuhle, apho zinegalelo ekuzinzeni nasekusebenzeni kweefomyula ezifana neekhrimu, ii-lotions, kunye nee-liposomes.
Ukuqukumbela, iiphospholipids zivela kwimvelaphi yokutya neyemizi-mveliso, zidlala indima ebalulekileyo kwisondlo somntu, kwimpilo, nakwiinkqubo ezahlukeneyo zemizi-mveliso. Ukuqonda imithombo eyahlukeneyo kunye nokusetyenziswa kweephospholipids kubalulekile ekuqondeni ukubaluleka kwazo kwisondlo, kwimpilo, nakwimizi-mveliso.
V. Uphando kunye nezicelo
A. Iindlela zoPhando lwangoku kwiPhospholipid
Isayensi Uphando lwangoku kwisayensi ye-phospholipid luquka uluhlu olubanzi lwezihloko ezigxile ekuqondeni ulwakhiwo, umsebenzi, kunye neendima ze-phospholipids kwiinkqubo ezahlukeneyo zebhayoloji. Iindlela zamva nje ziquka ukuphanda iindima ezithile ezidlalwa ziiklasi ezahlukeneyo ze-phospholipids kwi-cell signaling, i-membrane dynamics, kunye ne-lipid metabolism. Ukongeza, kukho umdla omkhulu wokuqonda indlela utshintsho kwi-phospholipid composition olunokuchaphazela ngayo i-cellular kunye ne-organismal physiology, kunye nophuhliso lweendlela ezintsha zohlalutyo zokufunda i-phospholipids kumanqanaba eseli kunye ne-molecular.
B. Izicelo zeMizi-mveliso kunye nezeMithi
IiPhospholipids zifumene izicelo ezininzi kwimizi-mveliso nakwimithi ngenxa yeempawu zazo zomzimba nezekhemikhali ezizodwa. Kwicandelo lemizi-mveliso, iiphospholipids zisetyenziswa njengeemulsifiers, stabilizers, kunye nee-encapsulating agents kwimizi-mveliso yokutya, izimonyo, kunye nokhathalelo lomntu. Kwimizi-mveliso yamayeza, iiphospholipids zisetyenziswa kakhulu kwiinkqubo zokuhambisa amayeza, kubandakanya ii-liposomes kunye ne-lipid-based formulations, ukuphucula ukunyibilika kunye nokufumaneka kwamayeza. Ukusetyenziswa kweephospholipids kwezi zicelo kuye kwandisa kakhulu impembelelo yazo kwimizi-mveliso eyahlukeneyo.
C. Izikhokelo zexesha elizayo kunye nemingeni kuPhando lwePhospholipid
Ikamva lophando lwe-phospholipid lithembisa kakhulu, kunye nezikhokelo ezinokubakho kuquka ukuphuhliswa kwezixhobo ezintsha ezisekelwe kwi-phospholipid kwizicelo ze-biotechnology kunye ne-nanotechnology, kunye nokuhlolwa kwe-phospholipids njengeethagethi zokungenelela konyango. Imingeni iya kubandakanya ukujongana nemiba enxulumene nokukhula, ukuphindaphinda, kunye nokusebenza kakuhle kweendleko zeemveliso ezisekelwe kwi-phospholipid. Ngaphezu koko, ukuqonda ukusebenzisana okunzima phakathi kwe-phospholipids kunye nezinye izinto zeseli, kunye nendima yazo kwiinkqubo zesifo, kuya kuba yindawo ebalulekileyo yophando oluqhubekayo.
D.I-Phospholipid LiposomalIimveliso eziNqabileyo
Iimveliso ze-liposomal ze-phospholipid ziyindawo ephambili ekugxilwe kuyo kwizicelo zamayeza. Ii-liposomes, ezingama-vesicles angqukuva akhiwe zii-bilayers ze-phospholipid, ziye zafundwa ngokubanzi njengeenkqubo zokuhambisa amayeza ezinokubakho. Ezi mveliso zibonelela ngeenzuzo ezifana nokukwazi ukufaka iziyobisi ezi-hydrophobic kunye ne-hydrophilic, zijolise kwizicubu ezithile okanye iiseli, kwaye zinciphise iziphumo ebezingalindelekanga zamayeza athile. Uphando oluqhubekayo kunye nophuhliso lujolise ekuphuculeni uzinzo, amandla okulayisha amayeza, kunye nokukwazi ukujolisa kwiimveliso ze-liposomal ezisekelwe kwi-phospholipid kwiintlobo ngeentlobo zezicelo zonyango.
Olu lwazi lubanzi lubonelela ngengqiqo kwicandelo elikhulayo lophando lwe-phospholipid, kubandakanya iindlela ezikhoyo ngoku, ukusetyenziswa kwemizi-mveliso kunye namayeza, iindlela kunye nemingeni yexesha elizayo, kunye nophuhliso lweemveliso ze-liposomal ezisekelwe kwi-phospholipid. Olu lwazi lubonisa iimpembelelo ezahlukeneyo kunye namathuba anxulunyaniswa ne-phospholipids kwiinkalo ezahlukeneyo.
VI. Isiphelo
A. Isishwankathelo seZiphumo eziphambili
IiPhospholipids, njengezinto ezibalulekileyo kwiimembrane zebhayoloji, zidlala indima ebalulekileyo ekugcineni ulwakhiwo kunye nomsebenzi weseli. Uphando lutyhile iindima ezahlukeneyo zeephospholipids kwi-cellular signaling, i-membrane dynamics, kunye ne-lipid metabolism. Iindidi ezithile zeephospholipids zifunyenwe zinemisebenzi eyahlukileyo ngaphakathi kweeseli, zichaphazela iinkqubo ezifana nokwahluka kweeseli, ukwanda, kunye ne-apoptosis. Ngaphezu koko, ukusebenzisana okuntsonkothileyo phakathi kweephospholipids, ezinye iilipids, kunye neeproteni zemembrane kuye kwavela njengento ebalulekileyo ebangela umsebenzi weseli. Ukongeza, iiphospholipids zinezicelo ezibalulekileyo zoshishino, ngakumbi kwimveliso yee-emulsifiers, izibambisi, kunye neenkqubo zokuhambisa amayeza. Ukuqonda ulwakhiwo kunye nomsebenzi weephospholipids kunika ulwazi malunga nokusetyenziswa kwazo okunokwenzeka kwezonyango kunye nezoshishino.
B. Impembelelo kwiMpilo nakuShishino
Ukuqonda ngokupheleleyo iiphospholipids kunefuthe elibalulekileyo kwimpilo nakwishishini. Kwimeko yempilo, iiphospholipids zibalulekile ekugcineni ukuthembeka kweseli kunye nokusebenza. Ukungalingani kwisakhiwo se-phospholipid kuye kwanxulunyaniswa nezifo ezahlukeneyo, kubandakanya iingxaki ze-metabolic, izifo ze-neurodegenerative, kunye nomhlaza. Ke ngoko, iindlela zokungenelela ezijolise ekuguquleni imetabolism ye-phospholipid kunye nomsebenzi zinokuba namandla okunyanga. Ngaphezu koko, ukusetyenziswa kweephospholipids kwiinkqubo zokuhambisa amayeza kunika iindlela ezithembisayo zokuphucula ukusebenza kakuhle kunye nokhuseleko lweemveliso zamayeza. Kwicandelo lemizi-mveliso, iiphospholipids zibalulekile kwimveliso yeemveliso ezahlukeneyo zabathengi, kubandakanya ii-emulsions zokutya, izinto zokuthambisa, kunye nefomyula zamayeza. Ukuqonda ubudlelwane bolwakhiwo kunye nomsebenzi weephospholipids kunokuqhuba ubuchule kwezi shishini, okukhokelela kuphuhliso lweemveliso ezintsha ezinozinzo oluphuculweyo kunye nokufumaneka kwezinto eziphilayo.
C. Amathuba oPhando oluQhubelekayo noPhuhliso
Uphando oluqhubekayo kwisayensi ye-phospholipid lubonelela ngeendlela ezininzi zophando nophuhliso oluqhubekayo. Enye indawo ephambili kukucaciswa kweendlela zemolekyuli ezisisiseko sokubandakanyeka kwe-phospholipids kwiindlela zokubonisana kweseli kunye neenkqubo zesifo. Olu lwazi lunokusetyenziswa ekuphuhliseni unyango olujolise kulo oluguqula imetabolism ye-phospholipid ukuze kuzuze unyango. Ukongeza, uphando olongezelelweyo malunga nokusetyenziswa kwe-phospholipids njengezithuthi zokuhambisa amayeza kunye nophuhliso lweendlela ezintsha ezisekelwe kwi-lipid luya kuphucula intsimi yamayeza. Kwicandelo lemizi-mveliso, uphando oluqhubekayo kunye nemizamo yophuhliso inokugxila ekuphuculeni iinkqubo zemveliso kunye nokusetyenziswa kweemveliso ezisekelwe kwi-phospholipid ukuhlangabezana neemfuno zeemarike ezahlukeneyo zabathengi. Ngaphezu koko, ukuphonononga imithombo ezinzileyo neyobuhlobo nokusingqongileyo ye-phospholipids yokusetyenziswa kwimizi-mveliso yenye indawo ebalulekileyo yophuhliso.
Ngoko ke, isishwankathelo esipheleleyo sesayensi ye-phospholipid sigxininisa ukubaluleka okubalulekileyo kwe-phospholipids kumsebenzi weseli, amandla azo okunyanga kwimpilo, kunye nokusetyenziswa kwazo kwemizi-mveliso eyahlukeneyo. Ukuphononongwa okuqhubekayo kophando lwe-phospholipid kuveza amathuba anomdla okujongana nemingeni enxulumene nempilo kunye nokuqhuba ubuchule kwimizi-mveliso eyahlukeneyo.
Iireferensi:
Vance, DE, kunye noRidgway, ND (1988). I-methylation ye-phosphatidylethanolamine. Inkqubela phambili kuPhando lweLipid, 27(1), 61-79.
UCui, Z., uHouweling, M., kunye noVance, DE (1996). Ukuvezwa kwe-phosphatidylethanolamine N-methyltransferase-2 kwiiseli ze-hepatoma zeMcArdle-RH7777 zenza uhlengahlengiso lwamachibi e-phosphatidylethanolamine kunye ne-triacylglycerol ngaphakathi kweseli. Ijenali ye-Biological Chemistry, 271(36), 21624-21631.
UHannun, YA, kunye no-Obeid, LM (2012). Iiceramides ezininzi. Ijenali yeKhemistri yeBiological, 287(23), 19060-19068.
Kornhuber, J., Medlin, A., Bleich, S., Jendrossek, V., Henlin, G., Wiltfang, J., & Gulbins, E. (2005). Umsebenzi ophezulu we-asidi sphingomyelinase kuxinzelelo olukhulu. Ijenali ye-Neural Transmission, i-112 (12), i-1583-1590.
Krstic, D., kunye noKnuesel, I. (2013). Ukuchaza indlela esebenza ngayo isifo se-Alzheimer esiqala emva kwexesha. Nature Reviews Neurology, 9(1), 25-34.
UJiang, XC, Li, Z., kunye noLiu, R. (2018). UAndreotti, G, Ukuphinda Ujonge iLink phakathi kwePhospholipids, Ukuvuvukala kunye neAtherosclerosis. I-Clinical Lipidology, 13, 15–17.
UHalliwell, B. (2007). I-Biochemistry yoxinzelelo lwe-oxidative. I-Biochemical Society Transactions, 35(5), 1147-1150.
ULattka, E., uIllig, T., uHeinrich, J., kunye noKoletzko, B. (2010). Ngaba ii-fatty acids kubisi lomntu ziyakhusela ekutyebeni kakhulu? Ijenali yeHlabathi ye-Obesity, 34(2), 157-163.
UCohn, JS, kunye noKamili, A. (2010). UWat, E, kunye noAdeli, K, Iindima ezikhulayo ze-proprotein convertase subtilisin/kexin type 9 inhibition kwi-lipid metabolism kunye ne-atherosclerosis. Iingxelo ze-Current Atherosclerosis, 12(4), 308-315.
I-Zeisel SH. I-Choline: indima ebalulekileyo ngexesha lophuhliso losana olungekazalwa kunye neemfuno zokutya kubantu abadala. I-Annu Rev Nutr. 2006;26:229-50. doi: 10.1146/annurev.nutr.26.061505.111156.
ULiu L, uGeng J, uSrinivasarao M, et al. Iiphospholipids ezityebiswe yi-eicosapentaenoic acid ukuphucula ukusebenza kwe-neurobehavioral kwiimpuku emva kokwenzakala kwengqondo kwe-hypoxic-ischemic yeentsana ezisandula ukuzalwa. I-Pediatr Res. 2020;88(1):73-82. doi: 10.1038/s41390-019-0637-8.
UGarg R, uSingh R, uManchanda SC, uSingla D. Indima yeenkqubo ezintsha zokuhambisa iziyobisi ezisebenzisa ii-nanostars okanye ii-nanospheres. I-South Afr J Bot. 2021;139(1):109-120. doi: 10.1016/j.sajb.2021.01.023.
UKelley, EG, uAlbert, AD, kunye noSullivan, MO (2018). Ii-lipids zeMembrane, ii-Eicosanoids, kunye neSynergy of Phospholipid Diversity, iiProstaglandins, kunye neNitric Oxide. I-Handbook of Experimental Pharmacology, 233, 235-270.
van Meer, G., Voelker, DR, kunye noFeigenson, GW (2008). Ii-lipids ze-Membrane: apho zikhoyo kunye nendlela eziziphatha ngayo. Uphononongo lweNdalo i-Molecular Cell Biology, 9(2), 112-124.
Benariba, N., Shambat, G., Marsac, P., kunye noCansell, M. (2019). Inkqubela phambili kwi-Industrial Synthesis ye-Phospholipids. ChemPhysChem, 20(14), 1776-1782.
UTorchilin, iVP (2005). Inkqubela phambili yakutshanje ngee-liposomes njengabathwali bamayeza. Uhlolo lweNdalo Drug Discovery, 4(2), 145-160.
UBrezesinski, G., Zhao, Y., kunye noGutberlet, T. (2021). Iindibano zePhospholipid: i-topology yeqela eliphambili, itshaja, kunye nokuguquguquka. Uluvo lwangoku kwiColloid kunye neSayensi yoNxibelelwano, 51, 81-93.
Abra, RM, & Hunt, CA (2019). Iinkqubo zokuhambisa amayeza e-Liposomal: Uphononongo oluneminikelo evela kwi-Biophysics. Uphononongo lweeKhemikhali, 119(10), 6287-6306.
U-Allen, TM, kunye no-Cullis, PR (2013). Iinkqubo zokuhambisa amayeza e-liposomal: ukusuka kwingcamango ukuya kwizicelo zonyango. Uphononongo oluPhambili lokuhambisa amayeza, 65(1), 36-48.
Vance JE, Vance DE. I-Phospholipid biosynthesis kwiiseli zezilwanyana ezincancisayo. I-Biochem Cell Biol. 2004;82(1):113-128. doi:10.1139/o03-073
van Meer G, Voelker DR, Feigenson GW. Ii-lipids ze-Membrane: apho zikhoyo kunye nendlela eziziphatha ngayo. Nat Rev Mol Cell Biol. 2008;9(2):112-124. doi:10.1038/nrm2330
UBoon J. Indima yeephospholipids kumsebenzi weeproteni ze-membrane. I-Biochim Biophys Acta. 2016;1858(10):2256-2268. doi:10.1016/j.bbamem.2016.02.030
Ixesha lokuthumela: Disemba-21-2023
