Intshayelelo
Phospholippszizinto ezibalulekileyo ze-membragus zebhayiloji kwaye zidlale iindima ezibalulekileyo kwiinkqubo ezahlukeneyo zemzimba. Ukuqonda ubume babo kunye nomsebenzi kubalulekile ekuqondeni ubunzima beselula kunye ne-molecular biology, kunye nokubaluleka kwazo kwimpilo nakwizifo zabo. Olu luvo lubanzi olujolise ekuphefumleni ubume be-phospilids, bekhangela inkcazo kunye nolwakhiwo, kunye nokuqaqambisa ukubaluleka kokufunda ezi molekyuli.
A. Inkcazo kunye nolwakhiwo lwePhospholipids
Iphospholipids yiklasi ye-lipids equka imixokelelwane emibini yamanqatha, iqela le-phosphate, kunye ne-glycerone. Isakhiwo esahlukileyo sePhospholipids sibanceda ukuba benze i-lipid bilayer, isiseko se-membranes zeseli, kunye nemisila ye-hydrophobic ejonge ngaphakathi kunye neentloko ze-hydrophilic ezijonge phambili. Eli lungiselelo linika umqobo oguqukayo olawula ukuhamba kwezinto ngaphakathi nangaphandle kwiseli, ngelixa ikwacamngca iinkqubo ezahlukeneyo ezikwiselfowuni ezinjengokuphawula kunye nezothutho.
B. Ukubaluleka kokufunda phospilids
Ukufundisisa i-phospholipps kubalulekile ngenxa yezizathu ezininzi. Okokuqala, zibalulekile kwisakhiwo kunye nomsebenzi we-membranes zeseli, ukuphembelela ulwelo lwe-membrane, ubungqingqwa, kunye nozinzo. Ukuqonda iipropathi zephospholipids kubalulekile ekutyhilekeni kweendlela zeselula ezifana ne-endoristosis, i-ericytosis, kunye nokudluliselwa kwesiginali.
Ngapha koko, i-phospholipid ineempembelelo ezibalulekileyo kwimpilo yabantu, ngakumbi malunga neemeko ezinje ngesifo sentliziyo, ukuphazamiseka kwe-neurodenegenegenegenege, kunye ne-metabolic syndromes. Uphando kwi-phospholipids lunokubonelela ngoqeqesho kuphuhliso lwezicwangciso-qhinga zeNovellic kunye nongenelelo lokutya olujolise kule micimbi yezeMpilo.
Ukongeza, ukusetyenziswa kwemizi-mveliso kunye nentengiso yephospholipids kwiindawo ezinje ngamayeza, i-nandraceuticals, kunye ne-biotechnology igxile ngokubaluleka kokuqhubela phambili ulwazi lwethu kulo mhlaba. Ukuqonda iindima ezahlukeneyo kunye neepropathi zephospholipid kunokukhokelela kuphuhliso lweemveliso ezintsha kunye neetekhnoloji ezineempembelelo ezinokubangela ukuba impilo-ntle yomntu kunye nokuhambela phambili kwezobuchwephesha.
Ngesishwankathelo, ukufundisisa kweephospholipids kubalulekile ekutyhilekeni kwesakhiwo esineselpiteatime emva kweselfowuni kunye nomsebenzi, ukuhlola ifuthe labo kwimpilo yabantu, kunye nokudibanisa amandla abo kwizicelo ezahlukeneyo zeshishini. Olu luvo lubanzi lujolise ekuchitheni ukukhanya kuhlobo lwe-phospholipids kunye nokubaluleka kwazo kwimo yophando lwebhayoloji, impilo yomntu, kunye nokuveliswa kwetekhnoloji.
II. Imisebenzi ye-phospholipids
Iphospholipids, eyona nto ibalulekileyo ye-membranes yeseli, dlala indima eyahlukeneyo ekugcineni kweselfowuni kunye nomsebenzi, kunye nefuthe leenkqubo ezahlukeneyo zomzimba. Ukuqonda imisebenzi ye-phospholipid ibonelela ngokuqonda ngokubaluleka kwabo kwimpilo nakwisifo.
A. Indima kwi-Implane yeSMBRNANANALY NENKONZO
Umsebenzi webhayoloji ophambili wePhospholipids yigalelo labo kwisakhiwo kunye nomsebenzi weeseli zeseli. Iphospholipps iFomu ye-Lipid, isakhelo esisiseko se-membrane yeSolnsi, ngokuzilungiselela imisila yabo ye-hydrophobic ngaphakathi kunye neentloko ze-hydrophilic ngaphandle. Olu lwakhiwo ludala i-membrane enesidima elawula ukuhamba kwezinto ngaphakathi nangaphandle kweseli, ngaloo ndlela igcina ise seselstasis kunye nokwenza lula imisebenzi eyimfuneko efana nemveliso yesondlo, inkcitho, kunye neseli.
B. UKUFAKWA NOKUNXIBELELWANO KWIPOPE
Iphospholipps ikwasebenza njengezinto ezibalulekileyo kwiindlela zokubonisa kunye nonxibelelwano lweseli kwiselfowuni. Ezinye iiphospholipids, ezinjenge-phosphetidlinositol, zisebenzisa amaxhoba okubonisa iimolekyuli (umzekelo, i-Inositol Trisphosphate kunye ne-discylglycerol), umahluko wokukhula kwesel, umahluko kunye no-Apoptosis. Ezi molekyuli zidlala iindima eziphambili kwi-Cascals ezahlukeneyo kunye ne-cascals ebonisa i-cascals, ichaphazele iimpendulo ezahlukeneyo zomzimba kunye nokuziphatha kweselula.
C. Igalelo kwimpilo yengqondo kunye nokusebenza kwengqondo
Iphospholipps, ngakumbi i-phospfatidyllineline, kunye ne-phospfatidylline, zininzi kwingqondo kwaye zibalulekile ukuze zigcine ubume bayo kunye nomsebenzi. Iphospholipid igalelo kulwakhiwo kunye nokuzinza kweemitha ze-neurothols, uncedo ekukhutshweni kwe-neurotronsmitter kwaye ikhule, kwaye ibalulekile ekufundeni nememori. Ngapha koko, phosphelipids idlala indima kwiindlela ze-neuroprotectives kwaye ichaphazeleke ekusombululeni ukwehla kwengqondo ehambelana nokuphazamiseka kwesaluphelo kunye ne-neurological.
D. Impembelelo kwimpilo yentliziyo kunye nentliziyo yentliziyo
Iphospholipps ibonise iziphumo ezibalulekileyo kwimpilo yentliziyo kunye nentliziyo yentliziyo. Babandakanyeka kwisakhiwo kunye nomsebenzi we-lipoproteins, ehambisa i-cholesterol kunye nezinye i-lipids kwigazi. Iphospholipid ngaphakathi kwe-lipoproteins ifaka igalelo kuzinzo kunye nomsebenzi, ichaphazele i-lipid metabolism kunye ne-cholesterol mematis. Ukongeza, iphospholipids ifundwe amandla awo okhukumeza iiprofayili zegazi zegazi kwaye unciphise umngcipheko wezifo zentliziyo, zibalaselisa iimpembelelo zawo ezinokubakho ngokulawula impilo yentliziyo.
E. Ukubandakanyeka kwi-lipid metabolism kunye nemveliso yamandla
Iphospholipps ibalulekile kwi-lipid metabolism kunye nemveliso yamandla. Babandakanyeka kwi-synthesis kunye nokuqhekezwa kwee-lipids, kubandakanya ezinye zezodwa kunye ne-cholesterol, kwaye zidlale iindima ezigxekayo kwi-lipid ukuthuthwa kunye nokugcinwa. I-phospholikids ikwanegalelo kumsebenzi we-mitochondIals kunye nokuveliswa kwamandla ngokuzibandakanya kwabo kwiphosthorys ye-phosthory kunye ne-elektroni yezothutho, igxininisa ukubaluleka kwabo kwi-metabolism.
Kwisishwankathelo, imisebenzi ye-phospholipids ininzi kwaye iquka iindima zabo kwi-Iprane yeSomy kunye neMpilo-mali yeZenzo, kunye nokuNikezelwa kwentliziyo ye-Ipid Metabolism kunye nemveliso yamandla. Umbono obanzi obanzi unika ukuqonda okunzulu kwemisebenzi eyahlukeneyo ye-uphosple kunye neziphumo zabo kwimpilo-ntle yabantu.
III. Izibonelelo zeMpilo zePhospholipids
Iphospholipps zizinto ezibalulekileyo ze-membranes zeseli ezinemijikelezo eyahlukeneyo kwimpilo yabantu. Ukuqonda izibonelelo zezempilo zePhospholipid kunokusikhanyisa kwizicelo zazo ezinokubakho kunye nezicelo zesondlo.
Iziphumo kumanqanaba e-cholesterol
Iphospholipids idlala indima ebalulekileyo kwi-lipid metabolism kunye nezothutho, ezichaphazela ngokuthe ngqo amanqanaba e-cholesterol emzimbeni. Uphando lubonakalisile ukuba i-phospholipids inokulinganisa i-cholesterol metabolism ngokuchaphazela i-synthesis, i-abnger, kunye nokuncwina kwe-cholesterol. Iphospholipps ixeliwe ukuba incedise ekunikezelweni nasekuzinziseni amafutha yokutya, ngokwenza oko iququzelele ukufunxa i-cholesterol kumathumbu. Ukongeza, iphospipids zibandakanyeka ekumiselweni kwe-lipoproteins ephezulu (i-HDL), ezaziwa ngendima yazo ekususeni i-cholesterol engaphezulu kwigazi kunye nokunciphisa umngcipheko we-Atherosclerosis kunye nezifo zentliziyo. Ubungqina bucebisa ukuba iphospholipid inokubakho ukuphucula iiprofayili ze-lipid kwaye igalelo kulondolozo lwamanqanaba asempilweni emzimbeni.
Iipropathi ze-antioxididia
Iphospholipids ibonakalisa iipropathi ze-antioisoxidive enegalelo kwiziphumo zazo zempilo. Njengamacandelo abonakalisiweyo kwii-membranes zeselula, iiphospholipps zichaphazeleka kwimonakaliso ye-oxidatives yi-radicals yasimahla kunye neentlobo ze-teapgen ezisebenzayo. Nangona kunjalo, iphosphelipids inelungelo lokufumana i-amoiyoxidile, isebenza njengabakhuseli kwii-radicals zasimahla kunye nokukhusela iiseli kuxinzelelo lwe-oxidage. Izifundo zibonakalisile ukuba i-phospholipids ethile, enjenge-phosphetidylline kunye ne-phospfatidylethanolamine, inokuthobeka ngokufanelekileyo ukonakaliswa kwe-oxidative kunye nokuthintela i-lipid peroxidation. Ngaphaya koko, phospholiphids ziye zavela ekwandiseni inkqubo yokhuselo ye-Antioxidant ngaphakathi kweeseli, ngaloo ndlela zinika impembelelo yokukhusela ngokuchasene nomonakalo we-oxidages kunye ne-patrologies.
Izinto ezinokubakho kunye nezicelo zesondlo
Izibonelelo zempilo ezizodwa zephospholipid zivelise umdla kwizicelo zazo ezinokubakho kunye nezicelo zesondlo. Unyango olusekwe kwiphospholipid luyaphononongwa ngamandla abo ekulawuleni ukuphazamiseka okunxulumene ne-lipid, njenge hypercholestemia kunye ne-Dyslipidemia. Ngaphaya koko, phospholipids zibonakalise isithembiso ekukhuthazeni umsebenzi wezempilo wesibindi kunye nokuxhasa umsebenzi, ngakumbi kwiimeko ezibandakanya i-hetatic lipid kunye noxinzelelo lwe-oxidage. Ukusetyenziswa kwesondlo sePhospholipids kujongwa kwindawo yokutya okusebenzayo kunye nezongezo zokutya, apho kuqulunqa i-phospholipid khona yokuphucula ukonyusa i-phospid, ukukhuthaza impilo yentliziyo, kunye nenkxaso intlalo-ntle intlalo-ntle.
Ukuqukumbela, izibonelelo zezempilo zePispilids zibandakanya iziphumo zazo kumanqanaba e-cholesterol, iipropathi ze-antioxididia, kunye nezicelo zabo zesondlo. Ukuqonda iindima ezininzi zephospilipids ekugcineni umngcipheko we-HomeOstas kunye nokunciphisa umngcipheko kwizifo ezibonisa ukubaluleka kwabo ekukhuthazeni impilo-ntle yabantu ekuqhubeni impilo-ntle yabo.
Iv. Imithombo yephospholipids
Iphospholipps, njengezinto ezibalulekileyo ze-lipid ye-memy yeselula, zibalulekile ukuze zigcine ingqibelelo kunye nokusebenza kweeseli. Ukuqonda imithombo yephospholipids kuyinto ebaluleke kakhulu ekuqondeni ukubaluleka kwabo kokubini kwizicelo kunye nezicelo zeshishini.
A. Imithombo yokutya
Imithombo yokutya: I-Phospholiid inokufumaneka kwimithombo eyahlukeneyo yokutya, kunye nemithombo yolwazi eqinileyo ukuba yi-egg yolk, i-orte, kunye ne-soya. I-yolks yeqanda ininzi kakhulu kwi-phosphotidylcylline, uhlobo lwe-phospholipid, ngelixa iOybelipid inee-phosppharidylserene kunye ne-phosphotidylinositol. Eminye imithombo yokutya ye-phospholipids ibandakanya iimveliso zobisi, iipenuts, kunye nembewu yejongilanga.
Ukubaluleka kwebhayoloji: Iphospholipds ibalulekile kwisondlo se-WOL kwaye sidlale iindima eziphambili kwiinkqubo ezahlukeneyo zemzimba. Nje ukuba ungene, phospholipids zigayiwe kwaye ingene kumathumbu amancinci, apho bakhonza njengokwakha iibhloko zeseli zeseli ze-lipoprotein kwaye zinegalelo kwi-cholesterol kunye ne-triglycerides.
Iimpembelelo zezempilo: Uphando lubonakalisile ukuba uphot-phospholipids ezinokubakho, kubandakanya ukuphuculwa komsebenzi weSibindi, ukuxhasa impilo yobuchopho, kunye negalelo kwimpilo yentliziyo. Ngapha koko, phosphelipids ivela kwimithombo yaselwandle, enjengeoyile yeKrill, ifumene ingqalelo kubanika i-antill-insulmatory kunye neepropathi ze-antioculant.
B. Imithombo yemizi-mveliso kunye namayeza
Ukukhutshwa kwemizi-mveliso: Iphospipid ifunyenwe kwimithombo yemizi-mveliso, apho ikhutshwe kwizinto ezingafunekiyo zendalo ezinjengeesoya, imbewu yejongilanga, kunye nodliwanondlebe. Ezi phospholipid zenziwa kwaye zisetyenziswa kwizicelo ezahlukeneyo zeshishini, kubandakanya ukuveliswa kwee-EMULSIFIRs, izizwe, kunye neearhente zokutya, amayeza, kunye namashishini okutya.
Izicelo zamayeza: Iphospholiids zidlala indima ebalulekileyo kwishishini lamayeza, ngakumbi kwiinkqubo zokuhambisa iziyobisi. Zisetyenziswa njengezivumelwano ekuqulunqweni kweenkqubo zokuhambisa i-lipid ukuphucula ubume bebhayoloji, uzinzo, kunye nokujoliswa kwemali ejolise kumachiza. Ukongeza, phospholipids ziphononongiwe ukuze zikwazi ukuthutha i-novelths iziyobisi zokuhambisa ekujoliswe kuzo kunye nokukhululwa okuzinzileyo kweendlela.
Ukubaluleka kokushishina: Izicelo zemizi-mveliso yephospokilids zandise ngaphaya kwamayeza ukuze zisetyenziswe kwimveliso yokutya, apho bakhonza njenge-Emoniers kunye nokuzinzisa ngeendlela ezahlukeneyo zokutya. I-phospholipid isetyenziswa kwimveliso yookhathalelo lobuqu kunye neemveliso ze-cosmetic, apho zinegalelo kuzinzo kunye nokusebenza kwenkqubo yokwenziwa kunye ne-cresomes.
Ukuqukumbela, iiphospholipps zifunyenwe kuzo zombini imvelaphi yokutya nezommiselo, zidlala indima ebalulekileyo kwisondlo somntu, impilo, kunye neenkqubo ezahlukeneyo zeshishini. Ukuqonda imithombo eyahlukeneyo kunye nokusetyenziswa kwe-phospholikis kubaluleke kakhulu ekwenzeni ukubaluleka kwabo ngokwesondlo, impilo, kunye nomzi mveliso.
V. Uphando kunye nezicelo
A. Imikhwa yophando yangoku kwiPhosphelipid
Inzululwazi yoPhando yangoku kwiNzululwazi yePhospholipid ibandakanya uluhlu lwezihloko ngokubanzi ezijolise ekuqondeni ubume, umsebenzi kunye neendima zephospilipid kwiinkqubo ezahlukeneyo zebhayoloji. Iindlela zakutshanje zibandakanya ukuphanda iindima ezithile iindidi ezahlukeneyo zephospholipids kwiseli ezibonisa, i-membrane eguqukayo, kunye ne-lipid metabolism. Ukongeza, kukho umdla obalulekileyo ekuqondeni indlela utshintsho kwi-phospholifid kunye ne-ficumology, kunye nokuphuhliswa kweendlela ezintsha zokufunda uhlalutyo nakwimigangatho ye-molecular.
B. Izicelo zezamashishini kunye namayeza
Iphospholipps ifumene izicelo ezininzi zophuhliso kunye nezibulala-qabane ngenxa yepropathi yazo eyahlukileyo yomzimba kunye neekhemikhali. Kwicandelo lemizi-mveliso, iiphospholipids zisetyenziswa njenge-enulsifiers, izilo zokuzinzisa, kunye neearhente zokutya ekutyeni, ezinokutya kunye nemizi-mveliso yokhathalelo lobuqu. Kwiinkqubo zamayeza, phospholipids zisetyenziswa ngokubanzi kwiinkqubo zokuhanjiswa kweziyobisi, kubandakanya i-POSOSOMS kunye neefomuni ezisekwe kwi-lipid, ukomeleza isolula kunye nokungafumaneki kweziyobisi. Ukusetyenziswa kwe-phospholipid kwezi zicelo kuye kwandise kakhulu ifuthe labo kumashishini ahlukeneyo.
C. Izikhombisi ezizayo kunye nemiceli mngeni kuphando lwePhospholipid
Ikamva loPhando lwe-Phospholipid libambe isithembiso esikhulu, kunye nezikhombisi ezinokubandakanya izixhobo ezisekwe kwi-bispholipid yezixhobo ze-bisphelipid kunye ne-nanotechnotenocy, kunye nokuhlolwa kwe-phospholipids njengeethagethi zongenelelo ngoncedo. Imiceli mngeni iya kuqokelela ilungisa imiba enxulumene nokunganyamezelani, ukuzala kwakhona, kunye nokusebenza ngendleko zeemveliso ezisekwe kwiphospholipid. Ngaphaya koko, ukuqonda unxibelelwano oluntsonkothileyo phakathi kwee-phospipid kunye nezinye izinto eziselula, kunye neendima zabo kwiinkqubo zezifo, ziya kuba yindawo ebalulekileyo yophando oluqhubekayo.
D.Phosprelipid liposomalIimveliso ze-serial
I-Phospholipid i-Liposomal yeemveliso ze-Phospholipi yindawo ephambili yokugxila kwizicelo zamayeza. I-LIPOSOMS, eziziveli ze-verics ezenziwe ngo-phospholipid bilayers, ziye zafundwa kakhulu njengeenkqubo ezinokubakho iziyobisi. Ezi mveliso zinika izibonelelo ezinje ngamandla okuvelisa zombini iziyobisi kunye neziyobisi ze-hydrophilic, zijolise kwizicubu ezithile okanye iiseli, kwaye zinciphise iziphumo ebezingalindelekanga zamachiza athile. Uphando oluqhubekayo nophuhliso lujolise ekuphuculeni uzinzo, umthamo wokulayisha iziyobisi, kunye nokujolisa kwimveliso ye-phospholipid ye-phospholipid yoluhlu olubanzi lwezicelo zonyango.
Olu phawu lubanzi lubonelela ngokuqonda kwicandelo le-phosprenid yophando lwePspholipid, kubandakanya izinto ezikhoyo, iinkqubo zeshishini neziyeza kunye nophuhliso lweemveliso ze-phospholipid ezisisiseko. Olu lwazi luqaqambisa iimpembelelo ezahlukeneyo kunye namathuba ahambelana nePhospholipids kwimimandla eyahlukeneyo.
VI. Ukuqukumbela
A. Isishwankathelo sezinto eziphambili
Iphospholipids, njengezinto ezibalulekileyo zemfuza yebhayoloji, dlala indima ebalulekileyo ekugcineni kweselfowuni kunye nomsebenzi. Uphando luveze iindima ezahlukeneyo zephospholipids kwiselula, i-membrane eguqukayo, kunye ne-lipid metabolism. Iindidi ezithile zephospholipids zifunyenwe zinabasebenzi abahlukeneyo ngaphakathi kweeseli, kwiinkqubo zokuphembelela ezifana nokwahlula-hlukeneyo zeseli, ukuqhuba kunye ne-Apoptosis. Ngaphaya koko, ukungena ngaphakathi phakathi kwePisphelipids, ezinye ii-lipids, kunye neeproteri ze-membrane zivele njengesiqhelo somsebenzi weselula. Ukongeza, phospholipid zinezicelo ezibalulekileyo zemizi-mveliso, ngakumbi ekuvelisweni kwee-EMULSIFIERs, izilo zokuzinzisa, kunye neenkqubo zokuhambisa iziyobisi. Ukuqonda ubume kunye nomsebenzi wephospholikids ubonelela ngokuqonda kubuchwephesha babo obunokubakho kunye nokusetyenziswa kwemizi mveliso.
B. Iimpembelelo zeMpilo neMizi-mveliso
Ukuqonda okupheleleyo kwePhosphelipids kuneziphumo ezibalulekileyo kuzo zombini impilo kunye nemveliso. Kwimeko yempilo, phospholikis kubalulekile ekugcineni ukugcina i-sels egqibeleleyo kunye nomsebenzi. Ukungalingani kwi-Phospholipid yokwakhiwa kwe-phospholipid kunxulunyaniswa nezifo ezahlukeneyo, kubandakanya ukuphazamiseka kwe-metabolic, izifo ze-neurodegenelitionations, kunye nomhlaza. Ke ngoko, iindlela zongenelelo ekujoliswe kulo kwimongola ye-phospholipid metabolism kunye nomsebenzi kunokuba nezinto ezinokubakho. Ngapha koko, ukusetyenziswa kwe-phospholipid kwiinkqubo zokuhanjiswa kweziyobisi kubonelela ngeendlela ezithembisayo zokuphucula ukusebenza kunye nokhuseleko lweemveliso zamachiza. Kwinqanaba lemizi-mveliso, iphospholipids ibalulekile ekuvelisweni kweemveliso zabathengi ezahlukeneyo, kubandakanya ii-emssions zokutya, i-cosmetics, kunye neefomu zamayeza. Ukuqonda ubudlelwane bobudlelwane be-phospholipids unokuqhuba ubuchule kula mashishini, okukhokelela kuphuhliso lweemveliso ze-novel ngokuphuculwa kozinzo kunye nokuzifumana kufundiswayo.
C. Amathuba okuqhubeka nophando kunye nophuhliso
Uphando oluqhubekayo kwiNzululwazi yePhospholipid ibonisa iindlela ezininzi zokuphuculwa kunye nophuhliso. Inqaku elinye lesitshixo kukuyila kweendlela zemolekyuli ezisisiseko sephospholipid kwiindlela ezibonisa iindlela neenkqubo zezifo. Olu lwazi lunokutshintshwa ekuphuhliseni unyango olujolise kulo Ukongeza, ukuqhubela phambili kuphando ekusebenziseni i-phospholipid njengezithuthi zokuhambisa iziyobisi kunye nophuhliso lweefomu zeNovel Lipid ziya kuqhubela phambili intsimi yendawo yamayeza. Kwicandelo lemizi-mveliso, uphando oluqhubekayo kunye neenzame zophuhliso zinokugxila ekwenzeni iinkqubo zemveliso kunye nokusetyenziswa kweemveliso ezisekwe kwiphosphelipi ukuba zifezekise iimfuno zeemarike zabathengi ezahlukeneyo. Ngapha koko, ukuhlola imithombo emiselweyo nenobuhlobo yendalo yephospholipids yokusetyenziswa kwezamashishini lelinye indawo ebalulekileyo kuphuhliso.
Ke, isishwankathelo esibanzi se-phospholipid scanse Sciences ibalaselisa ukubaluleka kwe-phospholipids kumsebenzi weselula, amandla abo onyango, kunye nezicelo zawo zemveliso. Ukuqhubeka nokuhlolwa kophando lwePspilipi kuzisa amathuba achulumancisayo ekusombululeni imiceli mngeni enxulumene nezempilo kunye nokuqhuba ubuchule kumashishini ahlukeneyo.
Izalathiso:
I-Vince, De, & iRiggoway, ND (1988). I-methyling ye-phospytidylethanolamine. Inkqubela phambili kuphando lweLipid, 27 (1), 61-79.
I-cui, z., i-houweling, m., kunye ne-vies, de (1996). Inkcazo ye-phospretidyletletthanolamine n-methyltranferase-2 in MCardle-Rh7777 IiCople zilungisa i-PopracelidyletHyletHelthamine. Ijenali ye-Sheegistry Chemistry, 271 (36), 21624-21631.
I-Hannun, Ya, & Thid, Lm (2012). Uninzi lwe-ceramades. Ijenali ye-Chematigi yebhayiloji, 287 (23), 19060-19068.
U-Kornuber, u-Perlin, A., Blich, S., uJendrossesk, eGenlin, J., & Gulbins, E. (2005). Umsebenzi ophezulu we-acid spingalyelinase kuxinzelelo olukhulu. Ijenali yokudluliselwa okunesifo, 112 (12), 1583-1590.
I-Krtic, D., & Knienesel, I. (2013). Ukuthatha inxaxheba kwendlela yendlela yokuphambuka i-Alzheimer. Indalo iphonononge i-neurology, 9 (1), 25-44.
Jiang, xc, li, z., & liu, r. (2018). I-Andreotti, G, ihlaziya ikhonkco phakathi kwe-phospholipids, ukuvuvukala kunye ne-Atherosclerosis. I-lipidology yekliniki, 13, 15-17.
I-HobaIwell, B. (2007). I-biochemistry yoxinzelelo lwe-oxidage. Intengiselwano yoluntu ye-biochemical, 35 (5), 1147-1150.
I-LATTKA, e., I-Inc., Heinrich, J., & Kotletzko, B. (2010). Ngaba amanqatha aasids kubisi lomntu ukhusela kukutyeba? Ijenali yeHlabathi ye-OTEROLT, 34 (2), i-157-163.
Cohn, Js, & Kamili, A. (2010). Wat, E, E-Adeli, K, iindima ezisakhulayo ze-Proprotein Chest Pubrililin / I-Kexin Tepetion I-Ipid Metabolism kunye ne-Atherosclerosis. Iingxelo ze-AtheroscleroOss zangoku, 12 (4), 308-315.
Zeisel sh. I-Chominer: Indima ebalulekileyo ngexesha loPhuculo lweLindle kunye neemfuno zokutya kwabadala. Annu Recrence Nutr. 2006; 26: 229-50. I-DoI: 10.1146 / i-Annurev.nutr.26.061505.1115156.
Liu L, Geng J, Srinivasarao m, et al. Iphospholipid iikopantaic acid-i-phospicd phospholipps yokuphucula umsebenzi we-neurobehaviol kwi-rats ye-neotaal Hypoxic-ischemic ububi. I-Pediatr. 2020; 88 (1): 73-82. Doi: 10.1038 / S41390-019-0637-8.
Garg R, Singh r, Manchanda SC, u-Totla D. Indima yokuhambisa i-nools le-noves usebenzisa i-nanostars okanye inqwa. South Afric J B. 2021; 139 (1): 109-120. Doi: 10.1016 / J.SAJB.2021.01.023.
I-Kelley, umz., Albert, Ad, & Sullivan, Mo (2018). I-Membrane Lipids, i-eikononoids, kunye ne-synegy yeyantlukwano yePpholholid, i-Prostalandins, kunye ne-nitric oxide. Incwadana ye-Prememaclology ye-phermemoul, 233, 235-270.
I-Van Meer, G., I-Veeeker, Dr, & gegenson, GW (2008). I-membrane lipids: apho zikhona kwaye ziziphatha njani. Indalo iphonononge i-biology ye-moleor, 9 (2), 112-124.
I-Benaarba, n., shabsat, G., Marsac, P., & I-Cashll, M. (2019). Inkqubela phambili kwiSynthesi yeSoftware yePhospholipids. I-Chemvyyschem, 20 (14), 1776-1782.
Torchilin, i-VP (2005). Inkqubela-phambili yakutshanje nge-liposomes njengamayeza amachiza. Ukuphononongwa kwendalo, 4 (2), 145-160.
Brezesinski, G., Zhao, Y., & Gutberlet, T. (2021). Iindibano zephospholipid: I-topology yeqela lentloko, intlawulo, kunye nokuziqhelanisa. Izimvo zangoku kwi-colloid kunye nenzululwazi, 51, 81-93.
I-Abra, i-RM, & Hunt, C (CA (2019). Iinkqubo zokuhambisa i-liposomal zeziyobisi: Uphononongo ngeminikelo evela kwi-biophysics. Uhlaziyo lweekhemikhali, 119 (10), 6287-6306.
I-allen, i-TM, & PR (PR (PR (2003). Iinkqubo zokuhambisa i-liposomal zeziyobisi: Ukusuka kwimbono kwizicelo zeklinikhi. Uphononongo oluPhezulu lweziyobisi, 65 (1), 36-48.
Vance je, Vince de. Iphospholipid biosynthesis kwiiseli zeMammalian. I-Biochem Sel biol. Ngo-2004; 82 (1): 113-128. Doi: 10.1139 / O03-073
van meer g, i-ginder dr, gegenson gw. I-membrane lipids: apho zikhona kwaye ziziphatha njani. Nat Rece Mol I-biol yeseli. Ngo-2008; 9 (2): 112-124. Doi: 10.1038 / NRM2330
I-Boon J. Indima ye-phospholipid emsebenzini yeeproteri ze-membrane. I-Biochim Bhaphys Amema. 2016; 1858 (10): 2256-2268. Doi: 10.1016 / J.BAMEM.2016.02.03.030
Ixesha lokuphumla: I-DEX-21 ukuya kwi-2023
