I. Intshayelelo
Phospholipidszizinto ezibalulekileyo kwiinwebu zebhayoloji kwaye zidlala indima ebalulekileyo kwiinkqubo ezahlukeneyo zomzimba. Ukuqonda ukwakheka kunye nomsebenzi wabo kubalulekile ekuqondeni ubunzima bebhayoloji yeselula kunye nemolekyuli, kunye nokubaluleka kwabo kwimpilo yabantu nakwizifo. Olu phononongo lubanzi lujolise ekujongeni ubume obuntsonkothileyo be-phospholipids, ukuhlola inkcazo kunye nesakhiwo sabo, kunye nokugxininisa ukubaluleka kokufunda ezi molekyuli.
A. Inkcazo kunye noBume bePhospholipids
I-Phospholipids yiklasi ye-lipids equkethe amakhonkco amabini e-fatty acid, iqela le-phosphate, kunye ne-backbone ye-glycerol. Isakhiwo esiyingqayizivele se-phospholipids sibenza bakwazi ukwenza i-lipid bilayer, isiseko se-membrane yeseli, kunye nemisila ye-hydrophobic ejongene nangaphakathi kunye neentloko ze-hydrophilic ezibheke ngaphandle. Eli lungiselelo libonelela ngomqobo oguqukayo olawula ukuhamba kwezinto ngaphakathi nangaphandle kweseli, ngelixa udibanisa iinkqubo ezahlukeneyo zeselula ezifana nokubonisa kunye nokuthutha.
B. Ukubaluleka kokuFunda iiPhospholipids
Ukufunda i-phospholipids kubalulekile ngenxa yezizathu ezininzi. Okokuqala, zibalulekile kulwakhiwo kunye nomsebenzi weembrane zeseli, ziphembelela ulwelo lwenwebu, ukunyanzeliswa, kunye nokuzinza. Ukuqonda iipropathi ze-phospholipids kubalulekile ekutyhileni iindlela eziphantsi kweenkqubo zeselula ezifana ne-endocytosis, i-exocytosis, kunye nokudluliselwa kwesignali.
Ngapha koko, i-phospholipids inefuthe elibalulekileyo kwimpilo yabantu, ngakumbi malunga neemeko ezinje ngesifo sentliziyo, ukuphazamiseka kwe-neurodeergenerative, kunye ne-metabolic syndromes. Uphando malunga ne-phospholipids lunokubonelela ngengqiqo ekuphuhlisweni kwezicwangciso zonyango zonyango kunye nokungenelela kokutya okujoliswe kule miba yempilo.
Ukongezelela, ukusetyenziswa kwezoshishino kunye nezorhwebo ze-phospholipids kwiindawo ezifana namayeza, i-nutraceuticals, kunye ne-biotechnology igxininisa ukubaluleka kokuqhubela phambili ulwazi lwethu kule ndawo. Ukuqonda iindima ezahlukeneyo kunye neepropathi ze-phospholipids kunokukhokelela ekuphuhlisweni kweemveliso ezintsha kunye nobuchwepheshe obunempembelelo ebanzi kwintlalontle yoluntu kunye nokuqhubela phambili kwezobuchwepheshe.
Isishwankathelo, uphononongo lwe-phospholipids lubalulekile ekutyhileni isayensi entsonkothileyo ngasemva kolwakhiwo kunye nokusebenza kweeseli, ukuphonononga impembelelo yazo kwimpilo yabantu, kunye nokusebenzisa amandla abo kwizicelo ezahlukeneyo zemizi-mveliso. Olu qwalaselo lubanzi lujolise ekukhanyiseleni ubume bezinto ezininzi ze-phospholipids kunye nokubaluleka kwazo kwiindawo zophando lwebhayoloji, impilo yabantu, kunye nokwenziwa kwezinto ezintsha zobuchwepheshe.
II. Imisebenzi yebhayoloji yePhospholipids
I-Phospholipids, icandelo elibalulekileyo leembrane zeeseli, lidlala iindima ezahlukeneyo ekugcineni ubume beselula kunye nokusebenza, kunye nokuchaphazela iinkqubo ezahlukeneyo zomzimba. Ukuqonda imisebenzi yebhayoloji ye-phospholipids inika ukuqonda ngokubaluleka kwayo kwimpilo yabantu nakwizifo.
A. Indima kuLwakhiwo lweMembrane yeSeli kunye noMsebenzi
Umsebenzi oyintloko we-biological we-phospholipids yigalelo labo kwisakhiwo kunye nomsebenzi weembrane zeseli. I-Phospholipids zenza i-lipid bilayer, isakhelo esisisiseko seembumba zeseli, ngokuzilungiselela kunye nemisila yabo ye-hydrophobic ngaphakathi kunye neentloko ze-hydrophilic ngaphandle. Esi sakhiwo sidala i-membrane e-semipermeable elawula ukuhamba kwezinto ngaphakathi nangaphandle kweseli, ngaloo ndlela igcina i-homeostasis yeselula kunye nokuququzelela imisebenzi ebalulekileyo njengokuthatha izondlo, ukukhutshwa kwenkunkuma, kunye nokubonakaliswa kweeseli.
B. Umqondiso kunye noNxibelelwano kwiiSeli
Iiphospholipids zikwasebenza njengenxalenye ebalulekileyo yeendlela zokubonisa kunye nonxibelelwano lweseli ukuya kwiseli. Ezinye i-phospholipids, ezifana ne-phosphatidylinositol, zisebenza njengezandulela zokubonisa iimolekyuli (umzekelo, i-inositol trisphosphate kunye ne-diacylglycerol) elawula iinkqubo ezibalulekileyo zeselula, kubandakanywa ukukhula kweeseli, ukuhlukana, kunye ne-apoptosis. Ezi molekyuli zomqondiso zidlala indima ephambili kwii-cascades ezahlukeneyo ze-intracellular kunye ne-intercellular, ezichaphazela iimpendulo ezahlukeneyo zomzimba kunye nokuziphatha kweselula.
C. Igalelo kwiMpilo yeBrain kunye noMsebenzi woQoqosho
I-Phospholipids, ngokukodwa i-phosphatidylcholine, kunye ne-phosphatidylserine, ininzi kwingqondo kwaye ibalulekile ekugcineni isakhiwo kunye nomsebenzi wayo. I-Phospholipids inegalelo ekubunjweni nasekuzinzeni kwe-neuronal membranes, i-neurotransmitter release release and uptake, kwaye ibandakanyeka kwi-synaptic plasticity, ebaluleke kakhulu ekufundeni nasekukhumbuleni. Ngapha koko, i-phospholipids idlala indima kwiinkqubo ze-neuroprotective kwaye iye yabandakanyeka ekujonganeni nokuncipha kwengqondo okuhambelana nokuguga kunye nokuphazamiseka kwengqondo.
D. Impembelelo kwiMpilo yeNtliziyo kunye ne-Cardiovascular Function
I-Phospholipids ibonise imiphumo ebalulekileyo kwimpilo yentliziyo kunye nokusebenza kwentliziyo. Babandakanyeka kwisakhiwo kunye nomsebenzi we-lipoproteins, ezihambisa i-cholesterol kunye nezinye iilipids egazini. I-Phospholipids ngaphakathi kwe-lipoproteins igalelo ekuzinzeni nasekusebenzeni kwayo, ichaphazela i-lipid metabolism kunye ne-cholesterol homeostasis. Ukongezelela, i-phospholipids ifundelwe amandla abo okuguqula iiprofayili ze-lipid zegazi kunye nokunciphisa umngcipheko wezifo zentliziyo, ukugqamisa iziphumo zabo zonyango ekulawuleni impilo yentliziyo.
E. Ukubandakanyeka kwiLipid Metabolism kunye neMveliso yaMandla
I-Phospholipids ibalulekile kwi-lipid metabolism kunye nokuveliswa kwamandla. Babandakanyeka kwi-synthesis kunye nokuchithwa kwe-lipids, kuquka i-triglycerides kunye ne-cholesterol, kwaye badlala indima ebalulekileyo ekuthuthweni kwe-lipid kunye nokugcinwa. I-Phospholipids iphinda ibe negalelo kumsebenzi we-mitochondrial kunye nokuveliswa kwamandla ngokubandakanyeka kwabo kwi-phosphorylation ene-oxidative kunye ne-electron transport chain, egxininisa ukubaluleka kwayo kwi-metabolism yamandla eselula.
Isishwankathelo, imisebenzi yebhayoloji ye-phospholipids ininzi kwaye ibandakanya iindima zabo kwisakhiwo se-membrane yeseli kunye nomsebenzi, umqondiso kunye nonxibelelwano kwiiseli, igalelo kwimpilo yengqondo kunye nokusebenza kwengqondo, impembelelo kwimpilo yentliziyo kunye nokusebenza kwentliziyo, kunye nokubandakanyeka kwi-lipid metabolism kunye namandla. imveliso. Olu phononongo lubanzi lunika ukuqonda okunzulu kwemisebenzi eyahlukeneyo yebhayoloji ye-phospholipids kunye nefuthe labo kwimpilo yabantu kunye nokuphila kakuhle.
III. IiNzuzo zeMpilo zePhospholipids
I-Phospholipids zizinto ezibalulekileyo kwiinwebu zeseli ezineendima ezahlukeneyo kwimpilo yabantu. Ukuqonda inzuzo yezempilo ye-phospholipids kunokukhanyisa kwizicelo zabo zonyango kunye nezondlo.
Iziphumo kumaNqanaba eCholesterol
I-Phospholipids idlala indima ebalulekileyo kwi-lipid metabolism kunye nokuthutha, echaphazela ngokuthe ngqo amanqanaba e-cholesterol emzimbeni. Uphando luye lwabonisa ukuba i-phospholipids inokuguqula i-cholesterol metabolism ngokuchaphazela ukuhlanganiswa, ukufunxa, kunye nokukhupha i-cholesterol. Iiphospholipids ziye zaxelwa ukuba zincede emulsification kunye ne-solubilization yamafutha okutya, ngaloo ndlela iququzelela ukufunxa kwe-cholesterol emathunjini. Ukongezelela, i-phospholipids ibandakanyeka ekubunjweni kwe-high-density lipoproteins (HDL), eyaziwayo ngendima yabo ekususeni i-cholesterol engaphezulu kwigazi, ngaloo ndlela inciphisa umngcipheko we-atherosclerosis kunye nezifo zenhliziyo. Ubungqina bubonisa ukuba i-phospholipids inokuba namandla okuphucula iiprofayili ze-lipid kunye negalelo ekugcinweni kwamanqanaba e-cholesterol enempilo emzimbeni.
Iipropati ze-Antioxidative
I-Phospholipids ibonisa iimpawu ze-antioxidative ezinegalelo kwimiphumo yazo enenzuzo kwimpilo. Njengezinto ezidibeneyo zeembrane zeselula, i-phospholipids ichaphazeleka kumonakalo we-oxidative ngama-radicals amahhala kunye neentlobo ze-oksijini ezisebenzayo. Nangona kunjalo, i-phospholipids inomthamo we-antioxidative wendalo, osebenza njenge-scavengers yeeradicals zasimahla kunye nokukhusela iiseli kuxinzelelo lwe-oxidative. Uphononongo lubonise ukuba i-phospholipids ethile, efana ne-phosphatidylcholine kunye ne-phosphatidylethanolamine, inokunciphisa ngokufanelekileyo umonakalo we-oxidative kunye nokukhusela i-lipid peroxidation. Ngapha koko, i-phospholipids iye yabandakanyeka ekwandiseni inkqubo yokukhusela i-antioxidant ngaphakathi kweeseli, ngaloo ndlela yenze impembelelo ekhuselayo kumonakalo we-oxidative kunye ne-pathologies ehambelana nayo.
Izicelo ezinokubakho zokuNyanga kunye nezokutya
Izibonelelo zempilo ezikhethekileyo ze-phospholipids ziye zavelisa umdla kwizinto ezinokubakho zonyango kunye nezondlo. Unyango olusekelwe kwi-phospholipid luphononongwa ngamandla abo ekulawuleni iingxaki ezinxulumene ne-lipid, ezifana ne-hypercholesterolemia kunye ne-dyslipidemia. Ngaphezu koko, i-phospholipids ibonise isithembiso ekukhuthazeni impilo yesibindi kunye nokuxhasa ukusebenza kwesibindi, ngokukodwa kwiimeko ezibandakanya i-hepatic lipid metabolism kunye noxinzelelo lwe-oxidative. Ukusetyenziswa kwezondlo ze-phospholipids ziye zabonwa kwindawo yokutya okusebenzayo kunye nezongezelelo zokutya, apho iifospholipid-rich rich formulations ziphuhliswa ukuphucula i-lipid assimilation, ukukhuthaza impilo ye-cardiovascular, kunye nokuxhasa impilo yonke.
Ukuqukumbela, izibonelelo zezempilo ze-phospholipids zibandakanya iziphumo zazo kumanqanaba e-cholesterol, iipropathi ze-antioxidative, kunye nezicelo zabo ezinokuthi zonyango kunye nezondlo. Ukuqonda iindima ezininzi ze-phospholipids ekugcineni i-physiological homeostasis kunye nokunciphisa umngcipheko wesifo kunika ukuqonda okubalulekileyo ngokubaluleka kwabo ekukhuthazeni impilo yabantu kunye nokuphila kakuhle.
IV. Imithombo yePhospholipids
I-Phospholipids, njengenxalenye ye-lipid ebalulekileyo ye-membrane yeselula, ibalulekile ekugcineni ingqibelelo yesakhiwo kunye nokusebenza kweeseli. Ukuqonda imithombo ye-phospholipids kubaluleke kakhulu ekuqondeni ukubaluleka kwabo kwisondlo kunye nezicelo zoshishino.
A. Imithombo yokutya
Imithombo yokutya: I-Phospholipids inokufumaneka kwimithombo eyahlukeneyo yokutya, kunye neminye imithombo ecebileyo ibe yiqanda leqanda, inyama yenyama kunye neembotyi zesoya. Amaqanda amaqanda aninzi kakhulu kwi-phosphatidylcholine, uhlobo lwe-phospholipid, ngelixa iimbotyi zesoya ziqukethe i-phosphatidylserine kunye ne-phosphatidylinositol. Eminye imithombo yokutya ye-phospholipids ibandakanya iimveliso zobisi, i-peanuts, kunye nembewu yejongilanga.
Ukubaluleka kwezinto eziphilayo: I-phospholipids yokutya ibalulekile kwisondlo somntu kwaye idlala indima ebalulekileyo kwiinkqubo ezahlukeneyo zomzimba. Emva kokuba idliwe, i-phospholipids igaywe kwaye ifakwe emathunjini amancinci, apho isebenza njengeebhloko zokwakha iiseli zomzimba kunye negalelo ekuqulunqweni nasekusebenzeni kwee-lipoprotein particles ezihambisa i-cholesterol kunye ne-triglycerides.
Iimpembelelo zempilo: Uphando luye lwabonisa ukuba i-phospholipids yokutya inokuba neenzuzo zempilo, kubandakanywa nokuphucula ukusebenza kwesibindi, ukuxhasa impilo yengqondo, kunye negalelo kwimpilo ye-cardiovascular. Ngaphezu koko, i-phospholipids ephuma kwimithombo yaselwandle, njengeoli ye-krill, ifumene ingqalelo kwizinto ezinokuthi zichase ukudumba kunye ne-antioxidant.
B. Imithombo yoShishino kunye neMichiza
I-Industrial Extraction: Iiphospholipids zikwafumaneka kwimithombo yemizi-mveliso, apho zitsalwa kwizinto ezikrwada zendalo ezifana neembotyi zesoya, imbewu kajongilanga, kunye nembewu yerapeseed. Ezi phospholipids ke zicutshungulwa kwaye zisetyenziswe kwizicelo ezahlukeneyo zemizi-mveliso, kubandakanywa ukuveliswa kwe-emulsifiers, i-stabilizers, kunye nee-encapsulation agents zokutya, amayeza, kunye namashishini okuthambisa.
Ukusetyenziswa kwamachiza: I-Phospholipids idlala indima ebalulekileyo kwishishini lamachiza, ngakumbi kwiinkqubo zokuhanjiswa kweziyobisi. Zisetyenziswa njengabancedisi ekuqulunqweni kweenkqubo zokuhanjiswa kweziyobisi ezisekelwe kwi-lipid ukuphucula i-bioavailability, ukuzinza, kunye nokujoliswa kwee-pharmaceutical compounds. Ukongezelela, i-phospholipids ihlolwe amandla abo ekuphuhliseni abathwali bamachiza anoveli ekunikezelweni okujoliswe kuyo kunye nokukhululwa okuqhubekayo kwezonyango.
Ukubaluleka kuShishino: Ukusetyenziswa kwemizi-mveliso ye-phospholipids kunabela ngaphaya kwamayeza ukuquka ukusetyenziswa kwawo kwimveliso yokutya, apho asebenza njenge-emulsifiers kunye nezinzisi ekutyeni okwahlukeneyo okucutshungulweyo. Iiphospholipids nazo zisetyenziselwa ukuveliswa kokunyamekela komntu kunye neemveliso zokuthambisa, apho zifaka isandla ekuzinzeni nasekusebenzeni kokuqulunqwa okufana ne-creams, lotions, kunye ne-liposomes.
Ukuqukumbela, i-phospholipids ifunyenwe kwimvelaphi yokutya kunye nemveliso, idlala indima ebalulekileyo kwisondlo somntu, impilo, kunye neenkqubo ezahlukeneyo zamashishini. Ukuqonda imithombo eyahlukeneyo kunye nokusetyenziswa kwe-phospholipids kubalulekile ekuqondeni ukubaluleka kwabo kwisondlo, impilo kunye neshishini.
V. Uphando kunye nezicelo
A. IiNdlela zoPhando zangoku kwiPhospholipid
Inzululwazi Uphando lwangoku kwisayensi ye-phospholipid lubandakanya uluhlu olubanzi lwezihloko ezijolise ekuqondeni isakhiwo, umsebenzi, kunye neendima ze-phospholipids kwiinkqubo ezahlukeneyo zebhayoloji. Iindlela zamva nje zibandakanya ukuphanda iindima ezithile ezidlalwa ziindidi ezahlukeneyo ze-phospholipids kwi-cell signing, i-membrane dynamics, kunye ne-lipid metabolism. Ukongezelela, kukho umdla obalulekileyo ekuqondeni ukuba ukuguqulwa kokwakhiwa kwe-phospholipid kunokuchaphazela njani i-cellular kunye ne-organism physiology, kunye nokuphuhliswa kobuchule obutsha bokuhlalutya bokufunda i-phospholipids kumanqanaba eselula kunye neemolekyuli.
B. Izicelo zoShishino kunye nezaMachiza
I-Phospholipids ifumene izicelo ezininzi zemizi-mveliso kunye nezamayeza ngenxa yeempawu zabo ezizodwa kunye neekhemikhali. Kwicandelo lezoshishino, i-phospholipids isetyenziswa njenge-emulsifiers, i-stabilizers, kunye ne-encapsulating agents kwi-industry yokutya, i-cosmetic kunye neyomntu. Kwimichiza, i-phospholipids isetyenziswa ngokubanzi kwiinkqubo zokuhanjiswa kweziyobisi, kubandakanywa i-liposomes kunye ne-lipid-based formulations, ukuphucula ukunyibilika kunye ne-bioavailability yamachiza. Ukusetyenziswa kwe-phospholipids kwezi zicelo kuye kwandise kakhulu impembelelo yabo enokubakho kumashishini ahlukeneyo.
C. Izikhokelo zexesha elizayo kunye neMingeni kuPhando lwePhospholipid
Ikamva lophando lwe-phospholipid lunesithembiso esikhulu, kunye nezikhokelo ezinokuthi zibandakanye ukuphuhliswa kwezinto ezinoveli ze-phospholipid ezisekelwe kwi-biotechnological kunye ne-nanotechnological applications, kunye nokuhlolwa kwe-phospholipids njengeenjongo zokungenelela kwonyango. Imingeni iya kubandakanya ukujongana nemiba enxulumene nokunyuka, ukuveliswa kwakhona, kunye neendleko-zokusebenza kweemveliso ezisekelwe kwi-phospholipid. Ngaphezu koko, ukuqonda ukusebenzisana okunzima phakathi kwe-phospholipids kunye namanye amacandelo eselula, kunye neendima zabo kwiinkqubo zezifo, kuya kuba yinto ebalulekileyo yophando oluqhubekayo.
D.Phospholipid LiposomalIimveliso zothotho
Iimveliso ze-phospholipid liposomal yindawo ephambili ekugxilwe kuyo kwizicelo zamachiza. Ii-Liposomes, eziyi-spherical vesicles ezenziwe nge-phospholipid bilayers, ziye zaphononongwa ngokubanzi njengeenkqubo zokuhanjiswa kweziyobisi ezinokubakho. Ezi mveliso zibonelela ngezibonelelo ezinjengokukwazi ukufaka zombini iziyobisi ze-hydrophobic kunye ne-hydrophilic, kujoliswe kwizicubu ezithile okanye iiseli, kunye nokunciphisa iziphumo ebezingalindelekanga zamachiza athile. Uphando oluqhubekayo kunye nophuhliso lujolise ekuphuculeni ukuzinza, umthamo wokulayisha iziyobisi, kunye nokujolisa amandla emveliso ye-liposomal esekelwe kwi-phospholipid kuluhlu olubanzi lwezicelo zonyango.
Le nkcazo ebanzi inikezela ngengqiqo kwintsimi ekhulayo yophando lwe-phospholipid, kubandakanywa neendlela zangoku, izicelo zoshishino kunye nezamayeza, izikhokelo zexesha elizayo kunye nemingeni, kunye nokuphuhliswa kweemveliso ze-liposomal ezisekelwe kwi-phospholipid. Olu lwazi lugxininisa iimpembelelo ezahlukeneyo kunye namathuba ahambelana ne-phospholipids kwiinkalo ezahlukeneyo.
VI. Ukuqukumbela
A. Isishwankathelo seziphumo eziphambili
I-Phospholipids, njengenxalenye ebalulekileyo ye-membrane yebhayoloji, idlala indima ebalulekileyo ekugcineni ukwakheka kunye nokusebenza kweeseli. Uphando luye lwabonisa iindima ezahlukeneyo ze-phospholipids kwisignali yeselula, i-membrane dynamics, kunye ne-lipid metabolism. Iiklasi ezithile ze-phospholipids zifunyenwe zinemisebenzi eyahlukileyo ngaphakathi kweeseli, ezichaphazela iinkqubo ezinjengokwahlula kweeseli, ukwanda, kunye ne-apoptosis. Ngapha koko, unxibelelwano oluntsonkothileyo phakathi kwe-phospholipids, ezinye iilipids, kunye neeproteni ze-membrane ziye zavela njengeyona nto iphambili yokusebenza kweselula. Ukongeza, i-phospholipids inezicelo ezibalulekileyo zemizi-mveliso, ngakumbi kwimveliso ye-emulsifiers, i-stabilizers, kunye neenkqubo zokuhanjiswa kweziyobisi. Ukuqonda isakhiwo kunye nomsebenzi we-phospholipids kunika ulwazi malunga nokusetyenziswa kwabo kwezonyango kunye nezoshishino.
B. Iimpembelelo kwiMpilo kunye neShishini
Ukuqonda ngokubanzi i-phospholipids kunempembelelo ebalulekileyo kwimpilo kunye nakwishishini. Kwimeko yempilo, i-phospholipids ibalulekile ekugcineni ingqibelelo yamaselula kunye nomsebenzi. Ukungalingani ekubunjweni kwe-phospholipid kuye kwanxulunyaniswa nezifo ezahlukeneyo, kubandakanya ukuphazamiseka kwe-metabolic, izifo ze-neurodeergenerative, kunye nomhlaza. Ngoko ke, ukungenelela okujoliswe kuyo ukulungelelanisa i-phospholipid metabolism kunye nomsebenzi unokuba namandla okunyanga. Ngaphezu koko, ukusetyenziswa kwe-phospholipids kwiinkqubo zokuhanjiswa kweziyobisi kunika iindlela ezithembisayo zokuphucula ukusebenza kunye nokhuseleko lweemveliso zamayeza. Kwicandelo loshishino, i-phospholipids ibalulekile kwimveliso yeemveliso ezahlukeneyo zabathengi, kubandakanya i-emulsions yokutya, izithambiso, kunye nokwakhiwa kwamayeza. Ukuqonda ubudlelwane be-structure-function ye-phospholipids kunokuqhuba izinto ezintsha kula mashishini, okukhokelela ekuphuhlisweni kweemveliso zenoveli kunye nokuzinza okuphuculweyo kunye ne-bioavailability.
C. Amathuba oPhando noPhuhliso oluPhambili
Uphando oluqhubekayo kwisayensi ye-phospholipid lubonisa iindlela ezininzi zokuhlola nophuhliso. Enye indawo ephambili kukucaciswa kweendlela ze-molecular eziphantsi kokubandakanyeka kwe-phospholipids kwiindlela zokubonisa amaselula kunye neenkqubo zezifo. Olu lwazi lunokuxhaswa ukuphuhlisa unyango olujoliswe kuyo olumodareyitha i-phospholipid metabolism ukwenzela inzuzo yonyango. Ukongeza, uphando olongezelelweyo malunga nokusetyenziswa kwe-phospholipids njengezithuthi zokuhambisa amachiza kunye nokuphuhliswa kweendlela ezintsha ze-lipid-based formulations ziya kuqhubela phambili icandelo lamayeza. Kwicandelo lezoshishino, uphando oluqhubekayo kunye neenzame zophuhliso zinokugxila ekuphuculeni iinkqubo zokuvelisa kunye nokusetyenziswa kweemveliso ezisekelwe kwi-phospholipid ukuhlangabezana neemfuno zeemarike ezahlukeneyo zabathengi. Ngaphezu koko, ukuhlola imithombo ezinzileyo kunye nokusingqongileyo ye-phospholipids yokusetyenziswa kwezoshishino yenye indawo ebalulekileyo yophuhliso.
Ke, uphononongo olubanzi lwesayensi ye-phospholipid lubonisa ukubaluleka okubalulekileyo kwe-phospholipids kwimisebenzi yeselula, amandla abo onyango kukhathalelo lwempilo, kunye nezicelo zabo ezahlukeneyo zoshishino. Uphononongo oluqhubekayo lophando lwe-phospholipid lubonisa amathuba anomdla wokujongana nemingeni enxulumene nempilo kunye nokuqhuba izinto ezintsha kumashishini ahlukeneyo.
IiReferensi:
Vance, DE, & Ridgway, ND (1988). I-methylation ye-phosphatidylethanolamine. Inkqubela phambili kuPhando lweLipid, i-27 (1), i-61-79.
Cui, Z., Houweling, M., & Vance, DE (1996). Ukubonakaliswa kwe-phosphatidylethanolamine N-methyltransferase-2 kwi-McArdle-RH7777 iiseli ze-hepatoma zihlaziya i-intracellular phosphatidylethanolamine kunye namachibi e-triacylglycerol. Ijenali yeBiological Chemistry, 271(36), 21624-21631.
UHannun, YA, & Obeid, LM (2012). Iiceramide ezininzi. Ijenali yeBiological Chemistry, 287(23), 19060-19068.
Kornhuber, J., Medlin, A., Bleich, S., Jendrossek, V., Henlin, G., Wiltfang, J., & Gulbins, E. (2005). Umsebenzi ophezulu we-asidi sphingomyelinase kuxinzelelo olukhulu. Ijenali ye-Neural Transmission, i-112 (12), i-1583-1590.
Krstic, D., & Knuesel, I. (2013). Ukucacisa indlela esisiseko sesifo i-Alzheimer's. Uphononongo lweNdalo yeNeurology, 9 (1), 25-34.
Jiang, XC, Li, Z., & Liu, R. (2018). Andreotti, G, Ukuhlaziya iNxibelelwano phakathi kwePhospholipids, Ukuvuvukala kunye ne-Atherosclerosis. Clinical Lipidology, 13, 15-17.
Halliwell, B. (2007). I-biochemistry yoxinzelelo lwe-oxidative. I-Biochemical Society Transactions, 35 (5), 1147-1150.
Lattka, E., Illig, T., Heinrich, J., & Koletzko, B. (2010). Ngaba iiasidi ezinamafutha kubisi lomntu zikhusela ukutyeba? Ijenali yeZizwe ngezizwe yokuObesity, i-34 (2), i-157-163.
Cohn, JS, & Kamili, A. (2010). Wat, E, & Adeli, K, Iindima ezikhulayo zeproprotein ziguqula i-subtilisin / kexin uhlobo lwe-9 inhibition kwi-lipid metabolism kunye ne-atherosclerosis. Iingxelo zangoku ze-Atherosclerosis, i-12 (4), i-308-315.
Zeisel SH. I-Choline: indima ebalulekileyo ngexesha lokuphuhliswa komntwana kunye neemfuno zokutya kubantu abadala. UAnn uMfundisi Nutr. 2006;26:229-50. doi: 10.1146/annurev.nutr.26.061505.111156.
U-Liu L, uGeng J, uSrinivasarao M, kunye no-al. I-Phospholipid eicosapentaenoic acid-etyetyiswe phospholipids ukuphucula umsebenzi we-neurobehavioral kwiimpuku ezilandela ukwenzakala kwengqondo kwi-neonatal hypoxic-ischemic. I-Pediatr Res. 2020;88(1):73-82. doi: 10.1038/s41390-019-0637-8.
Garg R, Singh R, Manchanda SC, Singla D. Indima yeenkqubo zokuhanjiswa kweziyobisi ezinoveli usebenzisa i-nanostars okanye i-nanospheres. Umzantsi Afr J Bot. 2021;139(1):109-120. doi: 10.1016/j.sajb.2021.01.023.
Kelley, EG, Albert, AD, & Sullivan, MO (2018). I-Membrane lipids, i-Eicosanoids, kunye ne-Synergy ye-Phospholipid Diversity, i-Prostaglandins, kunye ne-Nitric Oxide. Handbook of Experimental Pharmacology, 233, 235-270.
van Meer, G., Voelker, DR, & Feigenson, GW (2008). IMembrane lipids: ziphi na kwaye ziziphatha njani. Uphononongo lweNdalo ye-Molecular Cell Biology, 9(2), 112-124.
Benariba, N., Shambat, G., Marsac, P., & Cansell, M. (2019). Ukuqhubela phambili kwi-Industrial Synthesis ye-Phospholipids. I-ChemPhysChem, i-20 (14), i-1776-1782.
Torchilin, VP (2005). Inkqubela phambili yamva nje kunye ne-liposomes njengabathwali bamayeza. Uphononongo lweNdalo ukuFumana kweZiyobisi, 4(2), 145-160.
Brezesinski, G., Zhao, Y., & Gutberlet, T. (2021). Iindibano ze-Phospholipid: i-topology ye-headgroup, intlawulo, kunye nokulungelelanisa. Izimvo zangoku kwiColloid & Interface Science, 51, 81-93.
Abra, RM, & Hunt, CA (2019). IiNkqubo zokuhanjiswa kweZiyobisi zeLiposomal: Uphononongo kunye neminikelo evela kwi-Biophysics. Uphononongo lweMichiza, i-119 (10), 6287-6306.
Allen, TM, & Cullis, PR (2013). Iinkqubo zokuhanjiswa kweziyobisi kwiLiposomal: ukusuka kwingqikelelo ukuya kwizicelo zeklinikhi. Uphononongo oluPhezulu loNikezelo lweziyobisi, 65(1), 36-48.
Vance JE, Vance DE. I-Phospholipid biosynthesis kwiiseli ezanyisayo. I-Biol yeSeli ye-Biochem. 2004;82(1):113-128. doi:10.1139/o03-073
van Meer G, Voelker DR, Feigenson GW. IMembrane lipids: ziphi na kwaye ziziphatha njani. Nat Rev Mol Cell Biol. 2008;9(2):112-124. doi:10.1038/nrm2330
Boon J. Indima ye-phospholipids kumsebenzi weeprotheni ze-membrane. Biochim Biophys Acta. 2016;1858(10):2256-2268. doi:10.1016/j.bbamem.2016.02.030
Ixesha lokuposa: Dec-21-2023
