Intshayelelo
IiGinsenosidesludidi lweekhompawundi zendalo ezifumaneka kwiingcambu zesityalo iPanax ginseng, ebesisetyenziswa kangangeenkulungwane kumayeza emveli aseTshayina. Ezi khompawundi ezisebenzayo zifumene ingqalelo enkulu kwiminyaka yakutshanje ngenxa yeenzuzo zazo zempilo ezinokubakho. Kweli nqaku, siza kuhlola iingenelo ezahlukeneyo ze-ginsenosides, kubandakanya nemiphumo yazo ekusebenzeni kwengqondo, ukuguqulwa kwenkqubo yomzimba yokuzikhusela, iipropati zokulwa nokuvuvukala, kunye nomsebenzi onokubakho wokulwa nomhlaza.
Umsebenzi wokuqonda
Enye yezona nzuzo zidumileyo ze-ginsenosides kukuba ziyakwazi ukuphucula ukusebenza kwengqondo. Izifundo ezininzi zibonise ukuba i-ginsenosides inokuphucula inkumbulo, ukufunda, kunye nokusebenza kwengqondo ngokubanzi. Ezi ziphumo kucingelwa ukuba zibangelwa ziindlela ezahlukeneyo, kubandakanya ukuguqulwa kwee-neurotransmitters, ezifana ne-acetylcholine kunye ne-dopamine, kunye nokukhuthaza i-neurogenesis, inkqubo yokuvelisa ii-neurons ezintsha engqondweni.
Kwisifundo esapapashwa kwiJournal of Ethnopharmacology, abaphandi bafumanise ukuba ii-ginsenosides zinokuphucula ukufunda kwendawo kunye nenkumbulo kwiimpuku ngokuphucula ukubonakaliswa kwe-brain-derived neurotrophic factor (BDNF), iproteni exhasa ukusinda nokukhula kwee-neurons. Ukongeza, ii-ginsenosides zibonakalisiwe ukuba zikhusela ekuwohlokeni kwengqondo okunxulumene nobudala kunye nezifo ze-neurodegenerative, ezifana nesifo se-Alzheimer's kunye ne-Parkinson's, ngokunciphisa uxinzelelo lwe-oxidative kunye nokudumba kwengqondo.
Ukuguqulwa kweNkqubo yoMzimba
Kukwafunyanwe ukuba ii-ginsenosides ziguqula inkqubo yomzimba yokuzikhusela, ziphucula amandla ayo okuzikhusela kwiintsholongwane nezifo. Ezi zinto zikhombisile ukuba zikhuthaza ukuveliswa kunye nomsebenzi weeseli ezahlukeneyo zokuzikhusela, ezifana neeseli zokubulala zendalo, ii-macrophages, kunye nee-T lymphocytes, ezidlala indima ebalulekileyo ekukhuseleni umzimba kwiintsholongwane kunye neeseli zomhlaza.
Uphononongo olupapashwe kwijenali ye-International Immunopharmacology lubonise ukuba ii-ginsenosides zinokuphucula impendulo yomzimba kwiimpuku ngokwandisa imveliso yee-cytokines, ezibonisa iimolekyuli ezilawula ukusebenza kweeseli zomzimba. Ngaphezu koko, ii-ginsenosides zibonakalisiwe zineempawu zokulwa neentsholongwane kunye neentsholongwane, nto leyo ezenza ukuba zibe sisisombululo sendalo esithembisayo sokuxhasa impilo yomzimba kunye nokuthintela usulelo.
Iimpawu zokuchasa ukudumba
Ukudumba yindlela yendalo yokusabela komzimba kwingozi kunye nosulelo, kodwa ukudumba okungapheliyo kunokunceda ekuphuhlisweni kwezifo ezahlukeneyo, kubandakanya isifo sentliziyo, isifo seswekile kunye nomhlaza. Kufunyenwe ukuba ii-ginsenosides zineempawu ezinamandla zokulwa nokudumba, ezinokunceda ekunciphiseni iziphumo eziyingozi zokudumba okungapheliyo emzimbeni.
Uphononongo olupapashwe kwiJournal of Ginseng Research lubonise ukuba ii-ginsenosides zinokuthintela ukuveliswa kwee-cytokines ezibangela ukuvuvukala kwaye zithintele ukusebenza kweendlela zokubonisa ukuvuvukala kwiiseli zomzimba. Ukongeza, ii-ginsenosides zibonakalisiwe ukuba zinciphisa ukubonakaliswa kwezinto ezibangela ukuvuvukala, ezifana ne-cyclooxygenase-2 (COX-2) kunye ne-inducible nitric oxide synthase (iNOS), ezibandakanyekayo kwimpendulo yokuvuvukala.
Umsebenzi Wokulwa Nomhlaza
Enye indawo enomdla kuphando lwe-ginsenoside ngumsebenzi wazo onokuthi ulwe nomhlaza. Izifundo ezininzi zibonise ukuba i-ginsenosides inokuba nefuthe elichasene nomhlaza ngokuthintela ukukhula nokwanda kweeseli zomhlaza, okubangela i-apoptosis (ukufa kweeseli okucwangcisiweyo), kunye nokucinezela i-tumor angiogenesis (ukwakheka kwemithambo yegazi emitsha ukuxhasa ukukhula kwe-tumor).
Uphononongo olupapashwe kwi-International Journal of Molecular Sciences lubonise amandla okulwa nomhlaza we-ginsenosides, ngakumbi kumhlaza webele, wemiphunga, wesibindi, nowe-colorectal. Olu phononongo luxoxe ngeendlela ezahlukeneyo ii-ginsenosides ezisebenzisa ngayo iziphumo zazo zokulwa nomhlaza, kubandakanya ukuguqulwa kwendlela yokuhambisa imiyalezo yeseli, ukulawula inkqubela phambili yomjikelo weseli, kunye nokuphucula impendulo yomzimba ngokuchasene neeseli zomhlaza.
Isiphelo
Ukuqukumbela, ii-ginsenosides ziikhompawundi ezisebenzayo ezifumaneka kwi-Panax ginseng ezibonelela ngeenzuzo ezahlukeneyo zempilo. Ezi ziquka ukuphuculwa komsebenzi wokuqonda, ukuguqulwa kwenkqubo yomzimba yokuzikhusela, iipropati zokulwa nokuvuvukala, kunye nomsebenzi onokuthi ulwe nomhlaza. Nangona uphando oluthe kratya lufuneka ukuqonda ngokupheleleyo iindlela zokusebenza kunye namandla okunyanga e-ginsenosides, ubungqina obukhoyo bubonisa ukuba ezi khompawundi zithembisa njengezonyango zendalo zokukhuthaza impilo-ntle iyonke.
Iireferensi
UKim, JH, kunye noYi, YS (2013). I-Ginsenoside Rg1 ithintela ukusebenza kweeseli ze-dendritic kunye nokwanda kweeseli ze-T kwi-vitro nakwi-vivo. I-International Immunopharmacology, 17(3), 355-362.
ULeung, KW, kunye noWong, AS (2010). I-Pharmacology ye-ginsenosides: uphononongo loncwadi. Amayeza aseTshayina, 5(1), 20.
Radad, K., Gille, G., Liu, L., Rausch, WD, kunye nokusetyenziswa kwe-ginseng kunyango kugxininiswa kwiingxaki ze-neurodegenerative. Ijenali yeSayensi yezeMithi, 100(3), 175-186.
UWang, Y., kunye noLiu, J. (2010). I-Ginseng, icebo elinokubakho lokukhusela imithambo-luvo. Unyango oluNcedisayo noluKhethekileyo oluSekelwe kuBungqina, 2012.
Yun, TK (2001). Intshayelelo emfutshane yePanax ginseng CA Meyer. Ijenali yeNzululwazi yezoNyango yaseKorea, i-16 (Suppl), i-S3.
Ixesha leposi: Epreli-16-2024
