Intshayelelo
Ginsenosidesludidi lweekhompawundi zendalo ezifumaneka kwiingcambu zePanax ginseng plant, esele isetyenziswe kangangeenkulungwane kumayeza emveli aseTshayina. Ezi khompawundi ze-bioactive ziye zafumana ingqwalasela ebalulekileyo kwiminyaka yakutshanje ngenxa yeenzuzo zabo zempilo. Kule nqaku, siza kuphonononga iingenelo ezahlukeneyo ze-ginsenosides, kubandakanywa neziphumo zabo ekusebenzeni kwengqondo, ukuguqulwa kwe-immune system, iipropathi ezichasayo, kunye nomsebenzi onokuthi ube nomhlaza.
Umsebenzi wokuqonda
Enye yeenzuzo ezaziwayo-kakuhle ze-ginsenosides kukukwazi kwabo ukuphucula umsebenzi wokuqonda. Izifundo ezininzi zibonise ukuba i-ginsenosides inokuphucula imemori, ukufunda, kunye nokusebenza kwengqondo ngokubanzi. Ezi ziphumo zicingelwa ukuba zixutywe ngeendlela ezahlukeneyo, kubandakanywa ukumodareyithwa kwee-neurotransmitters, ezifana ne-acetylcholine kunye ne-dopamine, kunye nokukhuthazwa kwe-neurogenesis, inkqubo yokuvelisa i-neurons entsha kwingqondo.
Kuphononongo olupapashwe kwi-Journal ye-Ethnopharmacology, abaphandi bafumanisa ukuba i-ginsenosides inokuphucula ukufundwa kwendawo kunye nememori kwiigundane ngokuphucula ukubonakaliswa kwe-brain-derived neurotrophic factor (BDNF), iprotheni exhasa ukusinda kunye nokukhula kwee-neurons. Ukongezelela, i-ginsenosides ibonakaliswe ukukhusela ekunciphiseni kwengqondo enxulumene neminyaka kunye nezifo ze-neurodeergenerative, ezifana ne-Alzheimer's kunye nesifo sika-Parkinson, ngokunciphisa uxinzelelo lwe-oxidative kunye nokuvuvukala kwengqondo.
UkuModareyithwa kweNkqubo yoMzimba
I-Ginsenosides ikwafunyaniswa ukuba imodareyitha amajoni omzimba, iphucula amandla ayo okuzikhusela kusulelo kunye nezifo. Ezi khompawundi zibonakaliswe ukuba zikhuthaza ukuveliswa kunye nomsebenzi weeseli ezahlukeneyo zokuzikhusela, ezinjengeeseli ezibulalayo zendalo, ii-macrophages, kunye ne-T lymphocytes, ezidlala indima ebalulekileyo ekukhuseleni umzimba kwi-pathogens kunye neeseli zomhlaza.
Uphononongo olupapashwe kwijenali yeHlabathi ye-Immunopharmacology ibonise ukuba i-ginsenosides inokonyusa impendulo yomzimba kwiimpuku ngokwandisa ukuveliswa kwee-cytokines, ezibonisa iimolekyuli ezilawula ukusebenza kweeseli zomzimba. Ngaphaya koko, i-ginsenosides ibonakaliswe ukuba ine-anti-viral kunye ne-anti-bacterial properties, ibenza ibe liyeza lendalo elithembisayo lokuxhasa impilo yomzimba kunye nokuthintela usulelo.
IiPropathi ezichasene nokudumba
Ukuvuvukala kuyimpendulo yendalo ye-immune system kukwenzakala kunye nokusuleleka, kodwa ukuvuvukala okungapheliyo kunokufaka isandla ekuphuhliseni izifo ezahlukahlukeneyo, kubandakanywa nesifo senhliziyo, isifo seswekile kunye nomhlaza. I-Ginsenosides ifunyenwe inezixhobo ezinamandla zokuchasa ukudumba, ezinokunceda ukunciphisa iziphumo ezinobungozi zokudumba okungapheliyo emzimbeni.
Uphononongo olupapashwe kwiJenali yoPhando lwe-Ginseng lubonise ukuba i-ginsenosides inokucinezela imveliso ye-cytokines e-pro-ukudumba kwaye inqanda ukusebenza kweendlela ezibonisa ukudumba kwiiseli zomzimba. Ukongezelela, i-ginsenosides ibonakaliswe ukunciphisa ukubonakaliswa kwabalamli abavuthayo, njenge-cyclooxygenase-2 (COX-2) kunye ne-inducible nitric oxide synthase (iNOS), echaphazelekayo kwimpendulo yokuvuvukala.
Umsebenzi wokulwa nomhlaza
Enye indawo enomdla kuphando lwe-ginsenoside ngumsebenzi wabo onokuthi ube nomhlaza. Izifundo ezininzi ziye zacebisa ukuba i-ginsenosides inokusebenzisa iziphumo zokuchasa umhlaza ngokuthintela ukukhula kunye nokwanda kweeseli zomhlaza, yenze i-apoptosis (ukufa kweseli ecwangcisiweyo), kunye nokucinezela i-angiogenesis ye-tumor (ukwenziwa kwemithambo yegazi emitsha ukuxhasa ukukhula kwethumba).
Uphononongo olupapashwe kwiJenali yeHlabathi yeSayensi yeMolekyuli yaqaqambisa amandla e-anticancer e-ginsenosides, ngakumbi kwibele, imiphunga, isibindi kunye nomhlaza we-colorectal. Uphononongo luxubushe iindlela ezahlukeneyo apho i-ginsenosides zisebenzisa iziphumo zabo zokuchasana nomhlaza, kubandakanya ukuguqulwa kwendlela yokubonakalisa iiseli, ukulawulwa kokuqhubekeka komjikelo weeseli, kunye nokwandiswa kokuphendula komzimba ngokuchasene neeseli zomhlaza.
Ukuqukumbela
Ukuqukumbela, i-ginsenosides ziikhompawundi ze-bioactive ezifumaneka kwi-Panax ginseng ezibonelela ngoluhlu olubanzi lweenzuzo zempilo ezinokubakho. Ezi ziquka ukuphuculwa komsebenzi wokuqonda, ukumodareyithwa kwe-immune system, iipropati ezichasayo, kunye nomsebenzi onokuthi ube nomhlaza. Nangona uphando olongezelelweyo lufunekayo ukuze kuqondwe ngokupheleleyo iindlela zokusebenza kunye namandla onyango e-ginsenosides, ubungqina obukhoyo bubonisa ukuba ezi zixhobo zibambe isithembiso njengeyeza zendalo zokukhuthaza impilo yonke kunye nokuphila kakuhle.
Iimbekiselo
UKim, JH, & Yi, YS (2013). I-Ginsenoside Rg1 icinezela ukusebenza kweeseli ze-dendritic kunye ne-T cell proliferation in vitro kunye ne-vivo. I-Immunopharmacology yamazwe ngamazwe, i-17 (3), i-355-362.
Leung, KW, & Wong, AS (2010). I-Pharmacology ye-ginsenosides: uphononongo loncwadi. Amayeza aseTshayina, i-5 (1), i-20.
I-Radad, K., Gille, G., Liu, L., Rausch, WD, & Ukusetyenziswa kwe-ginseng kumayeza ngokugxininisa kwiingxaki ze-neurodeergenerative. Ijenali yeeSayensi zePharmacological, 100 (3), 175-186.
Wang, Y., & Liu, J. (2010). I-Ginseng, isicwangciso esinokuthi sibe neuroprotective. Ubungqina obuSekwe kwiNgxaki eyongezelelweyo kunye neyeza elilolunye, ngo-2012.
Yun, TK (2001). Intshayelelo emfutshane yePanax ginseng CA Meyer. Ijenali yeNzululwazi yezoNyango yaseKorea, i-16 (Suppl), i-S3.
Ixesha lokuposa: Apr-16-2024
