Iindaba - Isayensi Engasemva kwe-Organic Agaricus Blazei Extract

I. Intshayelelo

I-Agaricus blazei, ekwaziwa ngokuba yi-"cogumelo do sol" okanye "i-sun mushroom", ifumene ingqwalasela enkulu kwiminyaka yakutshanje ngenxa yeenzuzo zayo zempilo. Eli nqaku liphonononga uphando lwesayensi olusemva isicatshulwa se-organic Agaricus blazeikunye neempawu zayo zonyango ezithembisayo.

Yintoni Eyenza I-Organic Agaricus Blazei Iphumelele Kangaka?

I-Organic Agaricus blazei extract iqulethe umxube owahlukileyo wee-bioactive compounds ezinegalelo kumandla ayo okunyanga:

-Ii-Beta-glucans:Ezi zii-polysaccharides ezintsonkothileyo ezifumaneka kwiifungi ezahlukeneyo nakwizityalo. Ii-Beta-glucans zaziwa kakhulu ngokukwazi kwazo ukuguqula inkqubo yomzimba yokuzikhusela. Ezinye izifundo zibonisa ukuba zikwanazo neempawu zokulwa nethumba, ezinokunceda ekuthinteleni okanye ekunyangeni umhlaza ngokunyusa amandla omzimba okuzikhusela ekujoliseni iiseli zomhlaza.

-I-Ergosterol:I-Ergosterol yikhompawundi ye-sterol efumaneka kwifungi kwaye isebenza njengophawu lokuqala kwi-vitamin D2 xa ivezwa kukukhanya kwe-ultraviolet. Ibonakaliswe ukuba ineempawu zokulwa nokuvuvukala kunye ne-antioxidant, ezinokunceda ekukhuseleni umzimba kwi-oxidative stress kunye nokudumba.

-UBlazein:I-Blazein yikhompawundi ye-sterol efumaneka kwiifungi ezithile, ingakumbi ii-mushroom ezityiwayo. Ifumene ingqalelo ngenxa yeempawu zayo zokulwa nomhlaza. Uphando lubonisa ukuba i-blazein inokunceda ekuthinteleni ukukhula kweeseli zomhlaza ngokuphazamisa iinkqubo zeeseli, nangona kufuneka uphando olongezelelekileyo ukuze kuqondwe ngokupheleleyo amandla ayo okunyanga ekuthinteleni nasekunyangeni umhlaza.

-I-Agaritine:I-Agaritine yikhompawundi yendalo efumaneka kwiikhowa, ingakumbi kwiintlobo ze-Agaricus. Nangona iphikisana ngenxa yokuba ityhefu inokuba khona xa ityiwa kakhulu, uphando oluthile lubonisa ukuba inokuba nefuthe lokulwa nomhlaza.

Kukholelwa ukuba ukusebenzisana phakathi kwezi zinto zimbini kuphucula iziphumo zonyango ze-Agaricus blazei extract. Ukulima ngokwendalo kuqinisekisa ukuba ezi zinto ziluncedo ziveliswa ngaphandle kokuchaphazela izibulali-zinambuzane okanye izichumisi ezenziweyo.

Izondlo eziphambili kwi-Organic Agaricus Blazei kwiMpilo

Ngaphaya kweekhompawundi zayo ezizodwa ze-bioactive,isicatshulwa se-organic Agaricus blazeisisidlo esityebileyo esinezakha-mzimba ezininzi:

-Iiproteni:Inika zonke ii-amino acids ezibalulekileyo, nto leyo eyenza ukuba ibe ngumthombo weproteni epheleleyo. Oku kuyenza ibe lukhetho oluhle kakhulu lokuxhasa ukukhula kwezihlunu, ukulungiswa, kunye nokusebenza komzimba ngokubanzi.

-Ifayibha:Ityebile kwifayibha enyibilikayo nenganyibilikiyo, ikhuthaza ukugaywa kokutya okunempilo. Ifayibha enyibilikayo inceda ekulawuleni amanqanaba e-cholesterol, ngelixa ifayibha enganyibilikiyo inceda ekugcineni ukuhamba kwamathumbu rhoqo.

-Iivithamini:Umthombo olungileyo weevithamini ze-B ezifana ne-riboflavin, i-niacin, kunye ne-pantothenic acid, ezibalulekileyo ekuveliseni amandla, imetabolism, kunye nokugcina ulusu kunye nemithambo-luvo isempilweni.

-Iiminerali:Iqulethe iiminerali ezibalulekileyo ezifana ne-potassium, i-phosphorus, i-magnesium, kunye ne-selenium. Ezi minerali zixhasa imisebenzi eyahlukeneyo yomzimba, kubandakanya ukulinganisela ulwelo, impilo yamathambo, kunye nokuzikhusela kwi-antioxidant.

-Ii-Antioxidants:Ubukho beekhompawundi zephenolic kunye ne-ergothioneine bubonelela ngokhuseleko olunamandla lwe-antioxidant, lunceda ekupheliseni ii-free radicals kunye nokunciphisa uxinzelelo lwe-oxidative, ngaloo ndlela luxhasa impilo iyonke.

Ukulinywa kwe-Agaricus blazei ngendlela yendalo kunokubangela uxinano olukhulu lwezondlo xa kuthelekiswa namakhowa akhuliswa ngendlela eqhelekileyo, nangona kufuneka uphando oluthe kratya ukuqinisekisa oku ngokuqinisekileyo.

Uphando malunga neempawu zonyango ze-Agaricus Blazei

Izifundo zesayensi ziphande ngeenzuzo ezahlukeneyo ezinokubakho kwimpilo ze-Agaricus blazei extract:

Inkxaso yeNkqubo yoKhuseleko loMzimba

Izifundo ezininzi zibonise iziphumo zokulungisa amasosha omzimbaisicatshulwa se-organic Agaricus blazeiiipolysaccharides:

- Ukwanda kwemveliso yee-cytokines ezifana ne-interleukin-1 beta kunye ne-tumor necrosis factor-alpha

- Ukwandiswa komsebenzi weeseli zokubulala zendalo

- Ukukhuthaza umsebenzi we-macrophage kunye ne-T-lymphocyte

Ezi ziphumo zinokuba negalelo ekuphuculeni ukuxhathisa izifo kwaye zixhase iimpendulo zomzimba zokulwa nomhlaza.

Amandla okulwa nomhlaza

Nangona uvavanyo lwezonyango ebantwini lulinganiselwe, uphando lwangaphambi kweklinikhi lubonise iziphumo ezithembisayo zokulwa nomhlaza:

- Ukuthintela ukukhula kwethumba kwiimodeli zezilwanyana zeentlobo ezahlukeneyo zomhlaza

- Ukuqaliswa kwe-apoptosis (ukufa kweeseli okucwangcisiweyo) kwimigca yeeseli zomhlaza

- Amandla okuphucula ukusebenza kakuhle kwe-chemotherapy eqhelekileyo

Kufuneka uphando olungqongqo ngakumbi ebantwini ukuqinisekisa ezi ziphumo kunye nokumisela idosi efanelekileyo kunye nokhuseleko.

Impilo yeMetabolic

Olunye uphando lubonisa ukuba i-Agaricus blazei extract inokuba nemiphumo emihle kwimilinganiselo ye-metabolic:

- Uphuculo lovakalelo lwe-insulin kunye ne-metabolism yeglucose kwiimodeli zezilwanyana ezinesifo seswekile

- Ukunciphisa amanqanaba e-cholesterol kunye ne-triglyceride iyonke

- Iziphumo ezinokubakho zokunciphisa umzimba ngokuguqula i-gut microbiota

Kufuneka uvavanyo lweklinikhi ebantwini ukuqinisekisa ezi ziphumo zokuqala.

Ukukhuselwa kwesibindi

Izifundo zezilwanyana zibonise iziphumo zokukhusela isibindiisicatshulwa se-organic Agaricus blazei:

- Umonakalo wesibindi onciphileyo kwiimodeli zokulimala kwesibindi okubangelwa ngamayeza

- Iziphumo ze-antioxidant ezinokukhusela iiseli zesibindi kuxinzelelo lwe-oxidative

- Amandla okuxhasa ukuvuselelwa kwesibindi

Uphando olongezelelekileyo luyimfuneko ukuze kuhlolwe iindlela ezibangela ezi ziphumo kunye nokusetyenziswa kwazo kwezonyango.

Umsebenzi wokulwa nokudumba

Iimpawu ze-Agaricus blazei zokulwa nokuvuvukala ziye zaphandwa kwiimeko ezahlukeneyo:

- Ukunciphisa iimpawu zokuvuvukala kwiimodeli zezilwanyana ze-colitis

- Iingenelo ezinokubakho kwiimeko ze-allergy ezifana ne-asthma

- Ukuguqulwa kweendlela zokudumba ezichaphazela isifo sentliziyo

Ezi ziphumo zokulwa nokudumba zinokuba negalelo kwiimpawu ezikhuthaza impilo ze-Agaricus blazei extract.

Isiphelo

Uphando lwenzululwazi kwi-organic Agaricus blazei extract lutyhila uluhlu oluntsonkothileyo lweekhompawundi ezisebenzayo eziphilayo ezithembisayo ezinamandla okunyanga. Nangona kufuneka uvavanyo olungakumbi lweklinikhi ebantwini ukuze kucaciswe ngokupheleleyo iziphumo zalo, ubungqina obukhoyo bubonisa ukuba le khowa inokubonelela ngenkxaso ekusebenzeni komzimba, impilo ye-metabolic, kunye nokuthintela umhlaza.

Njengoko umdla kwizisombululo zempilo yendalo uqhubeka ukhula, isicatshulwa se-organic Agaricus blazei simele indawo enomdla yophando oluqhubekayo lwesayensi. Iprofayili yaso yezakhamzimba ezikhethekileyo kunye neekhompawundi ezahlukeneyo zebhayoloji zenza ukuba ibe lulongezo oluxabisekileyo kwihlabathi lamakhowa amayeza. Ukuze ufumane ulwazi oluthe kratya malunga nomgangatho ophezuluisicatshulwa se-organic Agaricus blazeikunye nezinye izithako zezityalo, nceda unxibelelane nathi kule dilesi:grace@biowaycn.com.

Iireferensi

1. 1. 1.Firenzuoli F, Gori L, Lombardo G. I-Mushroom ye-Medicinal Agaricus blazei Murrill: Uphononongo lweeNcwadi kunye neengxaki ze-Pharmaco-Toxicological. I-Evid Based Complement Alternat Med. 2008;5(1):3-15.
  2. 2. Hetland G, Johnson E, Lyberg T, Kvalheim G. I-Mushroom Agaricus blazei Murill Ivelisa Imiphumo Yezonyango kwi-Tumor, i-Infection, i-Allergy, kunye ne-Inflammation ngokuguqula kwayo i-Innate Immunity kunye nokuphucula i-Th1/Th2 I-Immunity kunye ne-Inflammation. Adv Pharmacol Sci. 2011;2011:157015.
  3. 3.Wu MF, Chen YL, Lee MH, et al. Isiphumo se-Agaricus blazei Murrill extract kwiiseli zomhlaza wamathumbu omntu ze-HT-29 kwiimpuku ze-SCID ezikwi-vivo. Kwi-Vivo. 2011;25(4):673-677.
  4. 4. Yamanaka D, Motoi M, Ishibashi K, et al. Isiphumo se-Agaricus brasiliensis KA21 kumsebenzi wokulwa nethumba kunye neempendulo zomzimba kwiimpuku ezinethumba. J Nutr Sci Vitaminol (Tokyo). 2013;59(3):234-240.
  5. 5.Kozarski M, Klaus A, Nikšić M, et al. Imisebenzi ye-Antioxidative kunye nokuchazwa kweekhemikhali kwe-polysaccharide extracts ezivela kwiikhowa ezisetyenziswa kakhulu iGanoderma applanatum, iGanoderma lucidum, iLentinus edodes kunye neTrametes versicolor. J Food Compos Anal. 2012;26(1-2):144-153.