Yintoni iWheat Germ Extract Spermidine?

Inzululwazi ngasemva kweSpermidine

I-Spermidine yi-polyamine eyenzeka ngokwemvelo edlala indima ebalulekileyo kwiinkqubo zeselula. Iipolyamines, njengespermidine, zibalulekile ekukhuleni, ekuphindaphindeni nasekulondolozeni iiseli. Ezi zixhobo zibandakanyeka ngokukodwa kulawulo lwe-autophagy, inkqubo apho umzimba uphinde uhlambulule kwaye uhlambulule iiseli ezonakalisiweyo. Le ndlela yangaphakathi "yogcino lwendlu" ingundoqo kwimpilo kwaye ngoku inxulunyaniswa nokwehla okunxulumene nobudala.

Iziphumo zokuchasa ukuguga:I-Spermidine idibaniswe nemiphumo yokuchasana nokuguga, njengoko ifunyenwe ukuba iyancitshiswa kumanqanaba kunye nokuguga kwaye ihambelana nobomi obufutshane kunye neengxaki ezininzi, kubandakanywa ukungasebenzi komzimba, iimeko ezivuthayo, i-cardiovascular or nervous system, kunye ne-tumorigenesis.
Umsebenzi Wamajoni omzimba:I-Spermidine idlala indima ebalulekileyo ekusebenzeni kweeseli ze-immune, kubandakanywa ukwahlula kunye nokugcinwa kweeseli ze-T, iiseli ze-B, kunye neeseli zombulali wendalo (NK). Kwakhona negalelo kwi-polarization ye-macrophages ngokubhekiselele kwi-phenotype echasayo, ngaloo ndlela inceda ukunciphisa ukuvuvukala.
Ukunxibelelana neGut Microbiota:Ubungqina bubonisa ukuba i-gut microbiota inokwenza i-spermidine kwezinye iipolyamines okanye i-precursors yazo. Oku kusebenzisana phakathi kwebhaktheriya kunye nomninimzi kunokuchaphazela amanqanaba e-spermidine yomkhosi kunye nempilo yonke.
Ukhuseleko lwentliziyo:I-Spermidine ibonise imiphumo ye-cardioprotective, enokuthi ibe negalelo ekukhuselweni kwezifo zentliziyo.
I-Neuroprotection: Ikwabonise iziphumo ze-neuroprotective, ezinokuba luncedo ekulweni nezifo ze-neurodeergenerative.
UThintelo loMhlaza:Ngokuvuselela i-anticancer immunosurveillance, i-spermidine inokunceda ekuthinteleni umhlaza.
Ukulawulwa kweMetabolic: I-Spermidine ibandakanyeka kulawulo lwe-metabolic ye-polyamines, ebandakanya ukudibanisa phakathi komkhosi kunye ne-microbiota yayo.
Iimvavanyo zoNyango kunye noKhuseleko:Ekubeni i-spermidine ikhona ngokwemvelo kwisondlo somntu, iimvavanyo zeklinikhi zokwandisa ukuthathwa kwayo zibhekwa njengento enokwenzeka. Uphando luye lwenziwa ukuvavanya ukhuseleko lwe-spermidine, iziphumo zempilo, ukufunxa, imetabolism, kunye ne-bioprocessing.
Ukuqukumbela, i-spermidine iyimolekyuli enezinto ezininzi ezinokuchaphazela impilo yabantu, kubandakanywa nokuchasana nokuguga, ukusebenza komzimba, kunye nokukhuselwa kwizifo ezahlukahlukeneyo. Iindlela zayo zokusebenza zibandakanya ukusebenzisana kunye ne-gut microbiota, iiseli zomzimba, kunye neendlela ze-metabolic. Uphando olongezelelweyo kunye nolingo lwezonyango lunokuthi luphonononge amandla alo njengearhente yonyango.

Iprofayili yeSondlo seNkozo yeNkolo

Intsholongwane yengqolowa, inxalenye yenzala yokhozo lwengqolowa, inezondlo ezimangalisayo. Iqulethe ukugxila okuphezulu kwe-vitamin E, i-magnesium, i-zinc, kunye ne-fiber. Nangona kunjalo, into eyenza intsholongwane yengqolowa ibe yinto ekhethekileyo ngakumbi kumxholo we-spermidine. Ngelixa ubungakanani obuncinci be-spermidine bukhona kwiindawo ezahlukeneyo zokutya, intsholongwane yengqolowa ibonelela ngoxinaniso, ifom efikeleleka lula.

Iprotheyini:Intsholongwane yengqolowa ngumthombo olungileyo weprotheyini, equlathe zonke ezisibhozo ii-amino acids ezibalulekileyo, nto leyo eyenza ibe ngumthombo opheleleyo weprotheyini.
Ifayibha:Iqulethe i-fiber e-soluble kunye ne-insoluble, enceda ekucoleni kwaye inceda ukulawula amanqanaba eswekile yegazi.
IVithamin E:Ingqolowa yengqolowa yenye yemithombo ecebileyo ye-vitamin E, ngokukodwa ifom ye-tocopherol, i-antioxidant enamandla.
IiVithamini B:Ingumthombo ocebileyo weevithamini B, kuquka i-thiamin (B1), i-riboflavin (B2), i-niacin (B3), i-pantothenic acid (B5), i-pyridoxine (B6), kunye ne-folate (B9). Ezi vithamini zidlala indima ebalulekileyo kwimveliso yamandla kunye nokwakhiwa kweeseli ezibomvu zegazi.
I-Vitamin B12:Nangona ingafumaneki ngokuqhelekileyo kukutya kwezityalo, intsholongwane yengqolowa yenye yemithombo embalwa yezityalo ye-vitamin B12, eyimfuneko ekusebenzeni kwemithambo-luvo kunye nokuveliswa kwe-DNA kunye ne-RNA.
Ii-Acids ezinamafutha:Intsholongwane yengqolowa iqulethe ibhalansi elungileyo yamafutha e-monounsaturated kunye ne-polyunsaturated, kuquka i-omega-3 kunye ne-omega-6 fatty acids, eziyimfuneko kwimpilo yentliziyo.
Izimbiwa:Ingumthombo weeminerali ezahlukeneyo ezifana ne-magnesium, i-phosphorus, i-potassium, i-zinc, isinyithi, kunye ne-selenium, ebalulekileyo kwimisebenzi emininzi yomzimba.
IiPhytosterols:Intsholongwane yengqolowa iqulethe iiphytosterols, eziziikhompawundi zezityalo ezinceda ukunciphisa amanqanaba e-cholesterol.
Ii-Antioxidants:Ngaphandle kwevithamin E, intsholongwane yengqolowa iqulethe nezinye i-antioxidants ezinceda ukukhusela iiseli kumonakalo obangelwa yi-radicals yamahhala.
Iicarbohydrates:Inika iicarbohydrates ezintsonkothileyo, ezityiswa ngokucothayo kwaye zibonelela ngomthombo ozinzileyo wamandla.
Intsholongwane yengqolowa inokusetyenziswa ngeendlela ezahlukeneyo, njengezongezelelo kwi-smoothies, ifafazwe kwi-cereals, okanye njengesithako kwizinto ezibhakiweyo. Ngenxa yokuqulathwe ngamafutha aphezulu, inokuba ne-rancid ukuba ayigcinwanga kakuhle, ngoko ke kubalulekile ukuyigcina ikwifriji okanye ikhenkceziswe ukuze igcine ubutsha kunye nexabiso lesondlo sayo.

 

Isebenza njani iNqolowa Yentsholongwane yeSpermidine

Nje ukuba idliwe, i-spermidine evela kwi-wheat germ extract ifunnwe kwaye iqala indima yayo kwiinkqubo zeselula. Enye yeendlela zayo eziphambili kukwandiswa komsebenzi we-mitochondrial. I-Mitochondria, ehlala ichazwa njenge "powerhouses" yeseli, inoxanduva lokuvelisa amandla. Ngokuxhasa umsebenzi we-mitochondrial, i-spermidine ayincedi kuphela ekuveliseni amandla kodwa inceda ukunciphisa uxinzelelo lwe-oxidative, eyona nto ibalulekileyo ekugugeni. Nantsi indlela esebenza ngayo emzimbeni:

Ukungeniswa kwe-Autophagy:Enye yeendlela eziphambili apho i-spermidine icingelwa ukuba ibe negalelo kwimpilo kunye nokuphila ixesha elide kukukhuthazwa kwe-autophagy, inkqubo yeselula ebandakanya ukuthotywa kunye nokuphinda kusetyenziswe iinqununu zeselula ezonakalisiweyo. Le nkqubo ihambelana nokucocwa kwee-organelles ezonakalisiweyo kunye neeprotheyini ezidibeneyo, ezinokuthi ziqokelele ngobudala kwaye zibe negalelo kwizifo ezahlukahlukeneyo. Ngokukhuthaza i-autophagy, i-spermidine inokunceda ukugcina impilo yeselula kunye nomsebenzi.

Ukulawulwa kweGene Expression:I-Spermidine ibonakaliswe ukuba ichaphazela imeko ye-acetylation ye-histones kunye nezinye iiprotheni, ezinokuchaphazela i-gene expression. Inokuthintela i-histone acetyltransferases (i-HATs), ekhokelela kwi-deacetylation ye-histones kwaye inokuthi iguqule ukukhutshelwa kwezakhi zofuzo ezibandakanyekayo kwi-autophagy kunye nezinye iinkqubo zeselula.

Iziphumo ze-Epigenetic:I-Spermidine inokuchaphazela i-epigenome ngokuguqula i-acetylation ye-histones, iiprotheni ezijikeleze i-DNA. Oku kunokuchaphazela indlela iijini ezivezwa ngayo kwaye, ngenxa yoko, umsebenzi weselula kunye nempilo.

Umsebenzi weMitochondrial:I-Spermidine inxulunyaniswe nomsebenzi ophuculweyo we-mitochondrial, obalulekileyo kwimveliso yamandla ngaphakathi kweeseli. Inokukhuthaza ukuveliswa kwe-mitochondria entsha kunye nokuphucula ukucaciswa kwezonakalisiweyo ngenkqubo ebizwa ngokuba yi-mitophagy, eluhlobo lwe-autophagy olujolise ngokukodwa kwi-mitochondria.

Iziphumo zokuchasa ukudumba:I-Spermidine ibonise iipropati ezichasayo, ezinokuba luncedo ekunciphiseni ukuvuvukala okuhambelana nokuguga kunye nezifo ezahlukahlukeneyo ezinxulumene neminyaka.

Ukukhuselwa kuxinzelelo lwe-Oxidative:Njenge-polyamine, i-spermidine inokusebenza njenge-antioxidant, ikhusela iiseli kumonakalo obangelwa yi-oxygen esebenzayo (ROS), echaphazelekayo ekugugeni kunye nezifo ezininzi ezinxulumene nobudala.

Impembelelo kuMvalelo weSondlo kunye neSenescence yeSelula:I-Spermidine inokudlala indima kwiindlela zokubona izondlo, ezinokuchaphazela iinkqubo zeselula ezifana nokukhula, ukwanda, kunye ne-metabolism. Kuye kwacetyiswa ukuba kucinezele i-senescence yeselula, imeko yokubanjwa komjikelo weseli ongenakuguqulwa ohambelana nokuguga kunye nezifo ezinxulumene neminyaka.

Iidosi ezicetyiswayo zeNqolowa yeNtsholongwane yeSpermidine

Iingcali zincoma ukubandakanya i-spermidine ekudleni kwansuku zonke kwiimali ezincinci, ezilawulwayo. Idosi ecetyiswayo yeenzuzo ezizezona zilungileyo iyahluka, kodwa izifundo ezininzi zincoma phakathi kwe-1 ukuya kwi-5 milligrams ngosuku. Iidosi eziphezulu, ngakumbi kwifomu yokuncedisa, kufuneka zisetyenziswe ngononophelo, kwaye kuyacetyiswa ukuba udibane nochwepheshe bezempilo ngaphambi kokuba uqalise nayiphi na inkqubo entsha yokuncedisa.

Ukuqukumbela: Ikamva Eliqaqambileyo kunye neNqolowa yeNkomfa yeSpermidine

Intsholongwane yengqolowa i-spermidine inika ithuba elinomdla kwabo bafuna ukuphucula impilo yabo yonke kunye nokuphila ixesha elide. Ukukwazi kwayo ukukhuthaza ukuvuselelwa kweeseli, ukuphucula umsebenzi wokuqonda, kunye nokuxhasa inkqubo yokuguga enempilo ibeka njengesongezelelo esithembisayo. Ngophando oluqhubekayo, i-spermidine inokukhawuleza ibe sisiseko sempilo yokukhusela.