Yintoni i-ntshoni yengqolowa ekhupha intsholongwane?

Isayensi esemva kwe-spermidine

I-spermidine yi-Polyomine yendalo edlala indima ebalulekileyo kwiinkqubo zeselula. I-Polyamines, ezinje ngoSukhodi, ibalulekile ekukhuleni, ukuphindaphinda, kunye nokugcinwa kweeseli. Ezi computer zibandakanyeka ikakhulu ngokulandelelana kommiselo we-autophagy, inkqubo apho i-recles ehlaziyiweyo kunye neeseli ezonakalisiweyo. Olu qhinga lwangaphakathi "lokuzigcina"

Iziphumo ze-Anti-Age:I-spermidine idityaniswe kwiziphumo zokudanduluka, njengoko ifunyenwe incitshiswe kumanqanaba ekwenzini kwaye inxulunyaniswa ne-Lindespan emfutshane kwaye inxulunyaniswa nokungasebenzi kakuhle, kubandakanya imiba yokungasebenzi kakuhle, kunye ne-cumgegenesis.
Umzimba ophumyo:I-spermidine idlala indima ebalulekileyo ekusebenzeni ukuze isebenze, kubandakanya ukwahlula kunye nokugcinwa kweeseli ze-T, iiseli ze-B, kunye ne-killer yendalo (NK). Ikwanegalelo ekuhlekisweni kwe-macrophages ukuya kwi-anti-inframotype e-anti-inflaget, ngaloo ndlela ifuna ukunciphisa ukuvuvukala.
Unxibelelwano kunye ne-Gut microbiota:Ubungqina bucebisa ukuba i-Gut microbiiota inokutshintsha i-sperridine evela kwezinye iiposemines okanye amaqela abo. Oku kudibana phakathi kwentsholongwane kwaye umamkeli unokuphembelela amanqanaba omkhosi wezikhalazo kunye nempilo epheleleyo.
Ukukhusela i-Cardiovascular:I-spermidine ibonise iziphumo zentliziyo, enokuba negalelo ekuthinteleni izifo zentliziyo.
I-neuroproterate: Ikwabonisa iziphumo ze-neuroprouctive, ezinokuba yingenelo ekulweni izifo ze-neurodegenege.
Uthintelo lomhlaza:Ngokuvuselela i-anticialr i-anticialr i-shurnidance, i-spermidine inokunceda ekuthinteleni umhlaza.
UMmiselo weMetabolic: I-Spermidine ibandakanyeka kumgaqo-nkqubo wemetabolines ze-polyamines, ebandakanya i-interplay phakathi kwenginginya kunye ne-microbiota yayo.
Izilingo zeklinikhi kunye nokhuseleko:Ekubeni i-spermidine yendalo ikho ngoku ngokwenziwayo kwisondlo sabantu, uvavanyo lweklinikhi ukonyusa indawo yayo yokwakhiwa kuthathwa njengento enokwenzeka. Ukuqhutywa kophando kukwenziwe ukuze kuvavanye ukhuseleko lwe-swirrmidine, iziphumo zempilo, ukufunxa, imetabolism, kunye ne-bielocespeces.
Ukuqukumbela, i-spermidine yimolekyuli eninzi eneziphumo ezinokubakho kwimpilo yabantu, kubandakanya ukwaluphala, imisebenzi yomzimba, kunye nokukhusela kwizifo ezahlukeneyo. Iindlela zayo zomsebenzi zibandakanya ukusebenzisana ne-Gut Microbiiota, amasele okhuselo, kunye nemetabolic indlela. Uphando olungaphezulu novavanyo lweklinikhi lunokuphonononga amandla alo njengearhente yonyango.

Iprofayile yesondlo ye-ntsholongwane yengqolowa

I-ntshona yengqolowa, inxenye yokuzala yengqolowa yengqolowa, inolondlongo. Inolusizi oluphezulu lweVitamin E, iMagnesium, i-zinc kunye nefibre. Nangona kunjalo, yintoni eyenza intsholongwane yengqolowa nangakumbi ngumxholo wayo we-spermidine. Ngelixa inani elincinci leSpermidine likhona kwimithombo eyahlukeneyo yokutya, i-ntsholongwane yengqolowa ibonelela ngefom egxile kakhulu, efikelelekayo ngokulula.

Iprotein:I-Whait Germ ngumthombo olungileyo weprotheyini, oqulethe zonke ii-acid ezisibhozo eziyimfuneko, zenza ukuba ibe ngumthombo weprotein opheleleyo.
I-fiber:Iqulethe zombini ifibbhile enyibilikayo kunye ne-insuble fiber, i-AIDS ye-AIDS eklasini kwaye inceda ukulawula amanqanaba eswekile yegazi.
IVitamin E:I-Whama yengqolowa yenye yemithombo ye-vitamin e, ngokukodwa ifom ye-tocopherol, engu-Antioxidant onamandla.
B Vitamins:Ngumthombo otyebileyo weevithamini ze-B, kubandakanya i-themina (B1), i-riboflavin (B2), iNiacin (B3), iPantothec Acid (B5), i-Pyridoxine (B5). Ezi vithamini zidlala indima ebalulekileyo kwimveliso yamandla kunye nokwakha okubomvu kwegazi.
IVitamin B12:Nangona ingenziwanga ngokutya, ingqolowa yenye yemithombo yezityalo ezimbalwa zevithamin B12, ebaluleke kakhulu kumsebenzi we-nerve kunye nemveliso yeDNA neRNA.
Amafutha acids:I-ntshona yengqolowa inolungelelwano oluhle lwamafutha ahleliweyo kunye ne-Polynaturited iFato, kubandakanya i-Omega-3 ne-Omega-6 Fatty Acids, ebaluleke kakhulu kwimpilo yentliziyo.
Iiminerali:Ngumthombo weeminerals ezahlukeneyo njenge-magnesium, i-phosphorus, i-potassium, i-potassium, i-binc, iron, kunye ne-cleium, ebaluleke kwimisebenzi emininzi yomzimba.
I-Phytosterols:I-ntshoni yengqolowa iqulethe i-phytosterols, eziqokelela iikhomputha ezincedayo ezinceda amanqanaba e-cholesterol.
I-Antioxidants:Ngaphandle kweVitamin E, intsholongwane yengqolowa ikwanayo nayiphi na into enceda abanye abantu abanceda ukukhusela iiseli zomonakalo obangelwe yi-radicals yasimahla.
I-carbohydrate:Inika i-carbohydrate entsokothileyo, ethatyathwa kancinci kwaye inike umthombo oqinileyo wamandla.
I-ntsholongwane yengqolowa inokusetyenziswa ngeendlela ezahlukeneyo, ezinjengesongezelelo kwizinto ezifuzisayo, zifefu kwiinkozo, okanye njengesithako kwiimpahla ezibhakiweyo. Ngenxa yomxholo onamafutha ayo aphezulu, kunokuba yi-dolophu ukuba ayigcinwanga kakuhle, ngoko kubalulekile ukuyigcina ihlaziyiwe okanye iqanduselwe ukugcina ixabiso layo elitsha kunye nexabiso lesondlo.

 

Indlela ye-ntshoni ye-ntshoni ye-spermidine

Ukutyisa, i-spermidine evela kwingqolowa ye-gem ikhutshiwe kwaye iqala indima yayo kwiinkqubo zeselula. Enye yeendlela zayo eziphambili kukuphuculwa komsebenzi we-mitochond. I-mitochondria, ihlala ichazwa njenge "moya" weseli, inoxanduva lokuvelisa amandla. Ngokuxhasa umsebenzi we-mitochond, i-spermidine ayisiyo i-AIDS kwimveliso yamandla kodwa ikwanceda ekunciphiseni uxinzelelo lwe-oxidage, into ephambili ekwenzeni ukwaluphala. Nantsi indlela isebenza ngayo ngaphakathi emzimbeni:

I-Autophagy ingenise:Enye yeendlela eziphambili apho i-spermidine icingelwa ukuba negalelo kwimpilo kunye nobomi obude kukuvuselela i-autophagy, inkqubo yeselula ebandakanya ukonakaliswa kunye nokurisayikilisha izinto ezibekekileyo. Le nkqubo inxulunyaniswa nokukhutshwa kwemvume ye-organels eyonakeleyo kunye neprotheyini yeprotein, enokuqokelela ubudala kwaye inegalelo kwizifo ezahlukeneyo. Ngokukhuthaza i-Autophagy, i-spermidine inokunceda ukugcina impilo seselula kunye nomsebenzi.

Ukulawulwa kwentetho yesiphelo:I-spermidine ibonisiwe ukuba ichaphazele imeko ye-acety lottones kunye nezinye iiproteni, ezinokuphembelela intetho. Ingathintela i-ronetyranstonslesse (iminqwazi), ekhokelela kwi-Deacetyration yamaqhosha kunye nokuguqula ukupasa kweenkqubo ezichaphazelekayo kwiinkqubo ze-autopha kunye nezinye iinkqubo zeselphati.

Iziphumo ze-Epigenetiic:I-spermidine inokuba nefuthe kwi-epigenome ngokuguqula i-ACHETYIRD APTSE, ethi iprotheyini ejikeleze i-DNA inxeba. Oku kunokuchaphazela indlela evakaliswa ngayo imfuza kwaye, ngenxa yoko, ukusebenza kweselula kunye nempilo.

Umsebenzi we-mitochondI-spermidine idityaniswe nomsebenzi ophucukileyo we-mitochond, obalulekileyo kwimveliso yamandla ngaphakathi kweeseli. Inokukhuthaza ukuveliswa kwemveliso entsha ye-mitochondria kwaye iphucule imvume yoodayo ngenkqubo ebizwa ngokuba yi-mitophapham, olu luhlobo lwe-autophagy ejolise ngqo kwi-mitochondria.

Iziphumo ze-anti-insulmatory:I-spermidine ibonakalise iipropathi ezichasene ne-anti-insulmatory, ezinokuba yingenelo ekunciphiseni ukuvuvukala okunxulumene nokwaluphala kunye nezifo ezahlukeneyo ezinxulumene nobudala.

Ukukhuselwa kuxinzelelo lwe-oxidative:Njenge-Polyomine, i-spermidine inokusebenza njenge-Antioxidant, ukukhusela iiseli zomonakalo obangelwe ziintlobo ze-oxygen of i-oxygen, ezinamaxesha athatyathwayo kunye nezifo ezininzi ezinxulumene nobudala.

Impembelelo kwimvakalelo yesondlo kunye ne-selculance:I-spermidine inokuthi idlale indima kwindlela yokuqonda yesondlo, enokuba nefuthe kwiinkqubo zeselula njengokukhula, ukuqhuba, kunye neMetabolism. Icetyiswe ukuba ihlawule i-selcer yeselula, imeko yokulwa ukumbanjwa kweseli engenakuphikiswa okuhambelana nokwaluphala kunye nezifo ezinxulumene nobudala.

Imithombo ecetyiswayo ye-ntsholongwane yengqolowa ikhupha i-spermidine

Iingcali zicebisa ukubandakanya uSpermididi ekutyeni imihla ngemihla kwizixa ezincinci, ezilawulwa. Umthamo ocetyiswayo wezibonelelo ezifanelekileyo uyahluka, kodwa izifundo ezininzi zicebisa phakathi kwe-1 ukuya kwi-5 milligram ngemini. Imida ephezulu, ngakumbi kwifom yongezo, kufuneka ichithwe ngononophelo, kwaye kuyacetyiswa ukuba unxibelelane nenkqubo yezempilo ngaphambi kokuqala nawuphi na urhulumente ongezelelweyo.

ISIQINISEKISO: Ikamva eliqaqambileyo kunye ne-ntsholongwane yengqolowa

Ingqolowa i-Germ ikhuphe uMeridine ibeka ithuba elinomdla kwabo bajonge ukuphucula impilo yabo iyonke kunye nobomi obude. Amandla ayo okukhuthaza ukuphindaphinda kwakhona, ukuphucula ukusebenza kwengqondo, kunye nenkxaso yenkqubo yokwaluphala esempilweni njengesongezelelo. Ngophando oluqhubekayo, i-spermidine isenokuba lilitye lembombo lezempilo.