Iindaba - I-Ginsenosides ezinqabileyo: Umda olandelayo kwi-Herbal Medicine

I. Intshayelelo

Ehlabathini lamayeza esintu, ukufuna amayeza endalo aneenzuzo zempilo ezinamandla kuye kwakhokelela ekufumaneni i-ginsenosides enqabileyo.Ithatyathwe kwiingcambu zePanax ginseng, ezi khompawundi zodwa ziye zabangela umdla omkhulu kuluntu lwenzululwazi kunye nezonyango ngenxa yepropathi ethembisayo yekhemesti.Njengoko abaphandi bephanda nzulu kwindawo ye-ginsenosides enqabileyo, amandla abo okuguqula amayeza esintu aye abonakala ngakumbi.

II.Ukutyhilwa kobuncwane obufihliweyo

I-Ginsenosides, ekwabizwa ngokuba yi-ginseng saponins, zezona zinto ziphambili ze-bioactive ezifumaneka kwiginseng.Ngelixa ii-ginsenosides zemveli ezifana ne-Rg1, Rc, Rd, Re, Rb1, kunye ne-Rb2 ziye zaphononongwa ngokubanzi, indawo ejongiwe ngoku itshintshele koogxa babo abangaqhelekanga.I-ginsenosides enqabileyo, kuquka i-Rg3, i-Rk1, kunye ne-Rg5, ifumana ingqalelo kwiintlobo zabo ezahlukeneyo kunye nemiphumo enamandla ye-pharmacological.
Ezi ginsenosides ezinqabileyo zibonakaliswe ngezakhiwo zazo zeekhemikhali ezikhethekileyo kunye nemisebenzi eyahlukeneyo yezinto eziphilayo.Ngokungafaniyo noogxa babo abaqhelekileyo, i-ginsenosides enqabileyo ibonisa i-cholesterol-efana ne-4 trans-ring steroid skeleton eneentlobo ezahlukeneyo zeswekile, igalelo kwiipropati zabo ezikhethekileyo zonyango.

Ulwakhiwo lweMichiza:
I-ginsenosides enqabileyo ibonakaliswe nge-skeleton ye-4-ring steroid ekhethekileyo kunye namalungiselelo athile e-hydroxyl, i-glycosyl, kunye namanye amaqela asebenzayo.Olu lwakhiwo lwekhemikhali lwahlukileyo lubenza bahluke kwii-ginsenosides eziqhelekileyo kwaye badlala indima ebalulekileyo kwimisebenzi yabo yebhayoloji.Ubukho beentlobo ezininzi zeswekile kunye namaqela e-hydroxyl ngaphakathi kwesakhelo sekhemikhali yabo negalelo ekunyibilikeni kwabo, ukuzinza, kunye nokusebenzisana kunye neethagethi zeselula.

Ukwahlukana kwesakhiwo se-ginsenosides enqabileyo yinto ephambili kwikhono labo le-pharmacological, njengoko lichaphazela amandla abo okusebenzisana neethagethi ezahlukeneyo zeemolekyuli ngaphakathi komzimba.Olu bunzima besakhiwo luvumela i-ginsenosides enqabileyo ukuba isebenzise uluhlu olubanzi lweziphumo zebhayoloji, ibenze abaviwa abaxabisekileyo kwizicelo zonyango.

Imisebenzi yeBhayoloji eyahlukileyo:
I-ginsenosides ezinqabileyo zibonisa uluhlu lwemisebenzi yebhayoloji ezenza zahluke kumaqabane azo aqhelekileyo.Ezi zixhobo zibonakaliswe ukuba zine-anti-inflammatory, antioxidant, anti-cancer, neuroprotective, kunye ne-cardioprotective properties, phakathi kwabanye.Ukukwazi kwabo ukumodareyitha iindlela zokubonisa iselula, ukulawula ukubonakaliswa kofuzo, kunye nokusebenzisana neeprotheyini ezithile negalelo kwiziphumo zabo ezahlukeneyo zebhayoloji.

Umzekelo, ii-ginsenosides ezinqabileyo zibonise imisebenzi enamandla yokulwa nomhlaza, kubandakanya ukuthintela ukwanda kweeseli zethumba, ukufakwa kwe-apoptosis, kunye nokucinezelwa kwe-angiogenesis.Ukongeza, iziphumo zabo ze-neuroprotective zibonise isithembiso ekunciphiseni iimeko ze-neurodegenerative ngokuphucula ukusinda kwe-neuronal, ukunciphisa uxinzelelo lwe-oxidative, kunye nokulungelelanisa umsebenzi we-neurotransmitter.

Izakhiwo zeekhemikhali ezikhethekileyo ze-ginsenosides ezinqabileyo zibenza bakwazi ukusebenzisana neethagethi ezithile ze-molecular, ezifana ne-receptors, i-enzymes, kunye neemolekyuli zokubonisa, ezikhokelela ekuguqulweni kweenkqubo ezahlukeneyo ze-physiological.Lo msebenzi ojoliswe kuwo uvumela i-ginsenosides enqabileyo ukuba yenze imiphumo enzulu kumsebenzi weselula, ibenze ibe yimpahla ebalulekileyo ekuphuhlisweni kweendlela zokungenelela zonyango.

Isishwankathelo, izakhiwo zeekhemikhali ezahlukileyo kunye nemisebenzi eyahlukeneyo yebhayoloji ye-ginsenosides enqabileyo izibeka njengezinto ezixabisekileyo kwindawo yamayeza esintu.Ulungelelwaniso lwabo olulodwa lweemolekyuli kunye neziphumo ezininzi ze-pharmacological zigxininisa amandla abo okufaka isandla kuphuhliso lonyango olutsha lweemeko zempilo ezininzi.Njengoko uphando luqhubeka nokutyhila ubunzima be-ginsenosides enqabileyo, ukubaluleka kwabo ekubumbeni ikamva lamayeza endalo kubonakala ngokucacileyo.

III.Ukuphonononga ukubanakho kwePharmacological

Ikhono le-pharmacological ye-ginsenosides enqabileyo ngumxholo wophando olunzulu kunye nokuhlola.Uphononongo lubonakalise ukuba ezi khompawundi zinoluhlu olubanzi lwezinto eziphilayo, kubandakanywa nokuchasana nokudumba, i-antioxidant, i-anti-cancer, neuroprotective, kunye ne-cardioprotective effects.Ukukwazi kwabo ukumodareyitha iindlela ezahlukeneyo zokubonisa iiseli kunye neethagethi zemolekyuli zibenza babe ngabaviwa abathembisayo kuphuhliso lwenoveli yeearhente zonyango.

Enye yezona ndawo zinyanzelisayo zophando ziimpawu ze-anticancer ze-ginsenosides ezinqabileyo.Ezi khompawundi zibonise iziphumo ezichasene neproliferative kunye ne-pro-apoptotic kwimigca yeeseli zomhlaza ezahlukeneyo, zibonelela ngeendlela ezinokubakho zophuhliso lolunye unyango lomhlaza.Ukongeza, iziphumo zabo ze-neuroprotective ziye zabangela umdla kwizicelo zabo ezinokuthi zibe khona kwizifo ze-neurodeergenerative ezifana ne-Alzheimer's kunye ne-Parkinson.

Ukubophelela Amandla Onyango
Njengoko uluntu lwezenzululwazi luqhubeka lutyhila amandla onyango lwe-ginsenosides enqabileyo, umbuzo wokusebenzisa izibonelelo zabo kwimpilo yabantu uvela.Iingcali zempilo zincoma ukutya ingcambu yeginseng ekrwada okanye i-ginseng extract ukuze ungene kwiinzuzo ezinokubakho kwezi khompawundi.Kucetyiswa ukuba kuqalwe ngeedosi ezisezantsi kwaye ngokuthe ngcembe ukwandise ukuthatha ixesha ukulinganisa ukunyamezela komntu kunye nokuphendula.
Xa uqwalasela i-ginseng supplementation, kubalulekile ukukhetha izicatshulwa eziqhelekileyo eziqulethe ipesenti ethile ye-ginsenosides iyonke.Oku kuqinisekisa amandla angaguqukiyo kunye nokusebenza kakuhle, okuvumela abantu ukuba bandise ukufunxa kunye neziphumo zonyango ze-ginsenosides ezinqabileyo.

Imingeni kunye neNgqwalasela
Ngelixa amandla e-ginsenosides anqabileyo kumayeza esintu ayathembisa, kubalulekile ukujongana nemingeni enokubakho kunye nokuqwalaselwa.Ukusetyenziswa kwexesha elide kwePanax ginseng, ngakumbi kwiidosi eziphezulu, kunokukhokelela kwiziphumo ezibi ezinjengokuphuthelwa, kwaye kwezinye iimeko, ukuchasana okuqatha kunye nomonakalo wesibindi.Ke ngoko, kuyafuneka ukuba ulumke kwaye ufune isikhokelo sobuchule xa ufaka iimveliso zeginseng kwirejimeni yempilo yomntu.

Ukujonga Phambili
I-ginsenosides enqabileyo imele umda omtsha kumayeza esintu, enika ubutyebi bamathuba okujongana neemeko ezahlukeneyo zempilo kunye nokuphucula impilo-ntle jikelele.Njengoko uphando luqhubeka nokukhanyisa kwiipropati zabo ze-pharmacological kunye nobuchule bonyango, ukuhlanganiswa kwee-ginsenosides ezinqabileyo kwiindlela eziqhelekileyo zokunakekelwa kwezempilo kunesithembiso kwikamva leyeza lendalo.

Ukuqukumbela, ukuphononongwa kwe-ginsenosides enqabileyo kuphawula isahluko esinomdla kwi-evolution yamayeza esintu.Ngolwakhiwo lwazo lweekhemikhali ezizodwa kunye nemisebenzi eyahlukeneyo yebhayoloji, ezi khompawundi zikulungele ukuphinda zichaze imbonakalo yomhlaba yamayeza endalo kwaye zibe negalelo ekuqhubeleni phambili kwezempilo kunye nokuba sempilweni.

Njengoko singena kulo mda mtsha, amandla e-ginsenosides anqabileyo ukubumba ikamva lamayeza esintu lithemba elinyanzelisayo, elinika ithemba kwiindlela ezintsha zempilo kunye nokuphilisa.